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The clinical briefing

Medical news

8,171 articles

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Ophthalmology

Time Course of Resolution of Diabetic Macular Edema by Sustained Suppression of VEGF-A with the Port Delivery Platform with Ranibizumab

Sustained VEGF-A suppression via the Port Delivery System with ranibizumab effectively resolves diabetic macular edema with most patients achieving edema normalization; slow resolution may mimic treatment unresponsiveness, warranting reclas

Nov 5, 2026
Otorhinolaryngology

Unveiling the Impact of Social Vulnerability on Pediatric Obstructive Sleep Apnea Outcomes

This study highlights how social vulnerability correlates with higher asthma comorbidity and increased surgical intervention rates in children with obstructive sleep apnea, revealing disparities in disease severity and care pathways.

Nov 5, 2026
Gastroenterology

A Novel Endoscopic Classification Predicts Fundoplication Integrity and Pathologic Reflux After Antireflux Surgery

This study develops and prospectively validates a simple endoscopic classification of fundoplication integrity that reliably predicts pathological gastroesophageal reflux post-antireflux surgery, correlating with functional and clinical out

Nov 5, 2026
OB/GYN & Women's Health

Antidepressant Discontinuation During Pregnancy: Implications for Maternal Mental Health Emergencies

Discontinuation of antidepressants during pregnancy is common and linked to increased mental health-related emergency visits, underscoring the need for supportive treatment strategies for perinatal mental health.

Nov 5, 2026
Gastroenterology

Evolving Patterns and Outcomes of Idiosyncratic Drug-Induced Liver Injury in the U.S.: Insights from the 20-Year DILIN Prospective Registry

Analysis of 1,983 high-certainty DILI cases over two decades reveals shifting drug causes, declining severity, increased herbal and oncology-related cases, and higher mortality among elderly, patients with chronic liver disease, and oncolog

Nov 5, 2026
Neurology

Environmental Exposure to Water Pollutants and Progressive Supranuclear Palsy Risk: Insights from the UK Biobank

A nested case-control study from the UK Biobank reveals that living near water pollutant-emitting industrial facilities increases the risk of developing progressive supranuclear palsy, with risk influenced by pollutant type, distance, and d

Nov 5, 2026
Diabetes & Endocrinology

Safety Profile of SGLT2 Inhibitors in Elderly Patients with Type 2 Diabetes: Insights from a Population-Based Cohort Study

This study evaluates the safety of sodium-glucose cotransporter 2 inhibitors (SGLT2is) versus DPP-4 inhibitors in adults aged 75 and older with type 2 diabetes, demonstrating favorable safety outcomes for SGLT2is without increased harm.

Nov 5, 2026
Cardiology

Enhanced Cardiovascular Risk Prediction Through Combined LDL-C, Lp(a), and hsCRP Assessment in a Multiethnic Population

Combined measurement of LDL-C, lipoprotein(a), and hsCRP improves long-term prediction of atherosclerotic cardiovascular disease in a multiethnic cohort, highlighting important ethnic differences in absolute ASCVD risk.

Nov 5, 2026
Orthopedics

Long-Term Outcomes of Hip Arthroscopy for Femoroacetabular Impingement in Adolescents With Borderline Hip Dysplasia

This study compares 5-year postoperative outcomes of hip arthroscopy for femoroacetabular impingement in adolescents with borderline developmental dysplasia of the hip (BDDH) versus those without dysplasia, showing safety and efficacy with

Nov 5, 2026
Orthopedics

Evaluating Fall Risk in Older Adults: Insights from Reaction Time and Inhibitory Control Using ReacStick

This article reviews a study assessing fall risk in older adults through ReacStick-measured reaction time and inhibitory control, highlighting its superior precision over conventional tests and the protective role of knee extensor strength.

Nov 5, 2026
Dentistry

Unveiling the Impact of Suspected Cemental Tears on Periodontal Breakdown: Insights from a Massive Radiographic Study

A retrospective analysis reveals that suspected cemental tears on periapical radiographs associate with significant localized periodontal bone loss, highlighting the need for combined clinical and radiographic diagnostics.

Nov 5, 2026
Respiratory

Tozorakimab: A Promising Monoclonal Antibody to Reduce COPD Exacerbations

Tozorakimab, targeting interleukin-33, significantly reduces moderate to severe COPD exacerbations in former and current smokers despite standard inhaled therapy, offering a novel therapeutic approach with a favorable safety profile.

Nov 5, 2026
Rehabilitation Medicine

Precision in Energy Assessment: A New Resting Metabolic Rate Equation Tailored for Elite Cyclists

A novel RMR equation specific to elite cyclists improves energy expenditure estimation, supporting personalized nutrition and athletic performance optimization.

Nov 4, 2026
Rehabilitation Medicine

Safety and Effectiveness of High-Dose OnabotulinumtoxinA for Limb Spasticity: A Prospective Observational Study

This study evaluates the safety and effectiveness of onabotulinumtoxinA doses above 400 units for upper and lower limb spasticity, showing no new safety concerns and suggesting clinical benefits.

Nov 4, 2026
Dentistry

Postoperative Pain After Dental Procedures: Insights from the National Dental Practice-Based Research Network Using a Mobile Health Platform

This review synthesizes evidence from a large US network study on patient-reported postoperative dental pain, medication use, and functional interference, highlighting procedure-specific pain trajectories and opioid stewardship implications

Nov 4, 2026
Allergy & Immunology

Dual Remission of Atopic Dermatitis and Frequently Relapsing Nephrotic Syndrome With Dupilumab

A 9-year-old girl with atopic dermatitis and relapsing nephrotic syndrome achieved sustained remission of both conditions after dupilumab therapy, enabling withdrawal of steroids and tacrolimus.

Nov 4, 2026
Rheumatology

When and How to Image Polymyalgia Rheumatica: International Recommendations for a Targeted, Evidence-Based Approach

New international recommendations position imaging as a context-driven adjunct in polymyalgia rheumatica (PMR): not routine for clear cases, most helpful in intermediate or atypical presentations, and not recommended for routine monitoring.

Nov 4, 2026
Transplantation

Efficacy and Safety of GLP-1 Receptor Agonists in Managing Post-Transplant Diabetes Among Heart Transplant Patients: Insights from a Multicenter Spanish Study

This multicenter retrospective study shows that GLP-1 receptor agonists improve glycemic control and cardiometabolic parameters with good tolerance in heart transplant recipients with type 2 diabetes, supporting their therapeutic role in th

Nov 4, 2026
Dermatology

When Secondary Syphilis is Reliably Recognizable: Clinical and Histopathologic Insights into Condyloma Lata

This review synthesizes evidence on the characteristic clinical and histopathologic features of condyloma lata in secondary syphilis, emphasizing its reliable recognition to prevent misdiagnosis, especially at extragenital sites.

Nov 4, 2026Sign in to read
Clinical Updates

Enhanced Symmetry and Psychosocial Outcomes in Post-Traumatic Orbital Zygomatic Complex Reconstruction Using Patient-Specific Virtual Planning

This study demonstrates that patient-specific virtual mirrored-image planning significantly improves symmetry, globe positioning, malar projection, and psychosocial outcomes compared to traditional intraoperative visual estimation in late r

Nov 4, 2026
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  4. 04Cardiology

    Precision Medicine for Long QT Syndrome Type 2: Lumacaftor Corrects Trafficking Defects and Shortens QT Interval

  5. 05General Surgery

    Optimizing Postoperative Opioid Prescriptions After Intra-Abdominal Cancer Surgery: Comparing the 5x-Multiplier and 3-Tier Models

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