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This article reviews over 1100 studies on novel biomarkers for acute kidney injury (AKI) in critically ill patients, highlighting their predictive, diagnostic, and management roles while identifying gaps for future clinical implementation.
KDIGO 2026 updates anemia care in CKD: evidence-based thresholds for iron therapy, preference for IV iron on hemodialysis, ESA-first approach over HIF-PHIs, individualized Hb initiation, and an ESA maintenance upper Hb target <11.5 g/dL.
This article examines the debate on whether RAAS-modifying antihypertensives should be stopped before testing for primary aldosteronism, weighing diagnostic accuracy against patient safety and feasibility.
This article reviews expert perspectives on the efficacy and safety of SGLT inhibitors for cardiovascular and renal disease in type 1 diabetes, outlines translational insights from type 2 diabetes data, and proposes a roadmap for regulatory
Despite identical immunogenetic makeup, half of kidney transplant recipients from identical twins remain on calcineurin inhibitors, with no demonstrable benefit in rejection reduction or graft survival over 25 years, calling for critical re
Finerenone significantly slows kidney function decline and reduces cardiovascular risk in hypertensive non-diabetic CKD patients, with manageable safety profiles, supporting its therapeutic role beyond diabetes.
A 7-day perioperative sofosbuvir/velpatasvir prophylaxis in HCV-positive donor to HCV-negative recipient kidney transplants demonstrated sustained virologic response in over 92% of cases, with favorable 1-year graft survival and function.
Comprehensive pre- and early postoperative models predict acute kidney injury and need for renal replacement after lung transplantation, improving risk stratification and enabling targeted nephroprotection.
Researchers unveil ciliogenic pancreatopathy, a new pancreatic disease connected to ciliary gene mutations, highlighting its clinical significance in patients with syndromic ciliopathies and kidney dysfunction.
Finerenone reduces mortality, cardiovascular, and kidney complications in cardio-kidney-metabolic syndrome patients regardless of cancer history, while patients with cancer experience greater disease burden and adverse events.
Pre-liver transplantation elevated serum renin levels correlate with increased intraoperative vasopressor use and postoperative acute kidney injury, suggesting its potential as a predictive biomarker for perioperative management and renal r
Spatially distinct macrophage subsets interact with heterogeneous myofibroblast populations in lupus nephritis, driving maladaptive fibrosis and chronic kidney injury. Identifying these fibroinflammatory circuits offers promising targets fo
This review synthesizes evidence showing that Medicaid expansion under the Affordable Care Act significantly reduced 1-year mortality among young adults starting dialysis by improving insurance coverage and access to nephrology care.
Sequential use of normothermic regional perfusion and hypothermic machine perfusion in kidney transplants from DCD donors reduces delayed graft function, highlighting enhanced organ preservation strategies.
A multicenter cohort study shows that in critically ill patients undergoing continuous renal replacement therapy, mortality is more closely associated with fluid balance changes than net ultrafiltration rate, emphasizing patient-specific fl
This article reviews evidence linking cardiovascular-kidney-metabolic syndrome stages to liver fibrosis severity, progression, and liver-related events in metabolic dysfunction-associated steatotic liver disease (MASLD). Higher CKM stages i
This study identifies pre-transplant left atrial volume index as a potential predictor for overall one-year morbidity following kidney transplantation, highlighting its clinical relevance beyond traditional cardiac risk markers.
This study highlights varied outcomes of renal replacement therapy in critically ill patients, identifying subgroups who may benefit despite an overall increase in mortality risk.
RAAS inhibitors, used for kidney protection in sickle cell disease, may significantly exacerbate anemia by impairing erythropoiesis, warranting close hemoglobin monitoring in this vulnerable population.
Elevated plasma levels of H3.1 nucleosomes at ICU admission correlate with increased mortality and acute kidney injury requiring renal replacement therapy in sepsis, highlighting their potential as prognostic biomarkers.
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