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A 9-year-old girl with atopic dermatitis and relapsing nephrotic syndrome achieved sustained remission of both conditions after dupilumab therapy, enabling withdrawal of steroids and tacrolimus.
Cardiovascular risk prediction models show limited accuracy in postmenopausal women with chronic kidney disease, often underestimating risk, highlighting the need for improved tools in this high-risk population.
This study evaluates semaglutide’s benefits over dulaglutide or liraglutide among diabetic hemodialysis patients, highlighting improved survival, reduced hospitalizations, and greater weight loss with semaglutide.
Recent large-cohort analyses reveal that donor hospital distance from OPO headquarters does not increase deceased donor kidney nonuse, while policy changes like KAS250 temporarily raise nonuse rates but overall kidney utilization continues
An innovative, ultra-low-cost normothermic machine perfusion (NMP) system was developed and validated, enabling extended organ preservation and in vivo function in porcine and human tissues, offering affordable platforms for research and th
The phase 3 VISIONARY trial establishes sibeprenlimab as a promising therapy in IgA nephropathy, significantly stabilizing eGFR decline and reducing kidney-function deterioration over 24 months with a favorable safety profile.
Interim analysis of a phase 3 trial demonstrates povetacicept’s efficacy in reducing proteinuria and pathological markers in IgA nephropathy, with a favorable safety profile.
Ravulizumab, a terminal complement C5 inhibitor, significantly reduces proteinuria in adults with IgA nephropathy, demonstrating safety and biomarker improvements in phase 2 and 3 trials, highlighting its therapeutic potential.
Raman spectroscopy-based urine molecular fingerprinting offers a promising non-invasive biomarker to predict delayed graft function, assess baseline kidney allograft quality, and monitor transplant health postoperatively in patients receivi
A new OPTN policy removing race from eGFR calculations shows promise in increasing kidney transplantation access for Black patients by adding waiting time credits, while not disadvantaging others on the waitlist.
A novel nomogram using pretransplant triglycerides and body weight shows promise to guide early mycophenolate mofetil dosing after kidney transplantation, potentially reducing drug overexposure before therapeutic drug monitoring is feasible
This randomized trial compared intermittent hemodialysis and continuous renal-replacement therapy in critically ill AKI patients and found that continuous therapy was associated with lower 90-day mortality and similar kidney outcomes.
A randomized clinical trial demonstrates that adding intraoperative dobutamine to norepinephrine during surgical source control for septic shock significantly decreases postoperative acute kidney injury incidence and severity.
Indexing donor kidney parenchymal volume by recipient BMI via routine ultrasound strongly predicts one-year kidney graft function, offering a practical surrogate for graft-recipient size matching.
Italian data suggest prolonged warm ischemic times in donation after circulatory death do not compromise kidney and liver transplant outcomes when combined with advanced perfusion techniques, challenging traditional strict cutoffs.
The Semi-Elective Transplant Initiative (SETI) introduces a systems-based approach to deceased-donor kidney transplantation, improving logistics and graft utilization by shifting to proactive scheduling and expanded machine perfusion, witho
This study explores how physical activity influences lung and kidney function in COVID-19 survivors, showing active survivors had better lung outcomes but no significant kidney benefits, highlighting the importance of tailored rehabilitatio
New evidence suggests lower urine output thresholds than current standards better predict acute kidney injury, chronic kidney disease, and mortality in critically ill patients, urging redefinition of oliguria parameters in AKI diagnostics.
A validated set of 17 quality indicators (QIs) for lupus nephritis, derived from the 2025 EULAR recommendations, shows variable adherence in practice and an association between higher adherence and lower damage accrual in a tertiary-care co
This Swiss retrospective study reveals that while obesity in kidney transplant recipients increases early surgical complications and delayed graft function, it does not affect long-term patient or graft survival, suggesting obesity alone sh
