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This study examines differences in effect estimates between cluster-randomized and individually randomized clinical trials in prehospital, emergency, and critical care, revealing systematic bias in length-of-stay outcomes but not mortality.
Sepsis triggers mitochondrial impairment in platelets, promoting hyperactivation via ROS production. The mitochondria-specific antioxidant MitoTEMPO reverses these changes in vitro, suggesting therapeutic potential to prevent sepsis-related
An analysis of 27,773 pediatric tracheal intubations reveals 1.2% associated cardiac arrest, highlighting preventable factors such as multiple intubation attempts and benefits linked to video laryngoscopy and specific medications.
A significant brachial-to-radial arterial pressure gradient occurs in nearly one-fifth of critically ill patients receiving vasoactive agents, correlating with higher vasoactive doses, greater illness severity, and increased ICU mortality.
A deep learning model identifying ARDS features on chest X-rays independently predicts 28-day mortality and ventilator duration beyond traditional clinical measures in patients undergoing invasive mechanical ventilation.
The ISOREA survey highlights significant geo-economic disparities in ICU resources and organization worldwide, revealing critical gaps in critical care capabilities particularly in low-income settings, with implications for global health eq
A prospective study reveals that caregivers of ICU sepsis survivors frequently suffer long-lasting mental health issues strongly linked to patients’ mental impairments, underscoring the need for targeted mental health support.
The PELICAN trial found that individualized cardiac index-guided intraoperative hemodynamic therapy did not reduce major postoperative complications compared to routine care in high-risk major abdominal surgery patients.
A pooled analysis from the PRIME database reveals distinct ventilatory management patterns and ARDS incidence in neurocritical versus non-neurocritical patients, highlighting key associations between ventilator settings and outcomes.
This review synthesizes evidence linking tele-critical care with interhospital transfer patterns and outcomes, highlighting improved transfer selection and reduced low-value transfers among critically ill Medicare patients.
Elevated soluble ST2 worsens fulminant myocarditis by impairing cardiomyocyte mitochondria via IGF2R-YY1, providing a new prognostic biomarker and therapeutic target.
This randomized trial compared intermittent hemodialysis and continuous renal-replacement therapy in critically ill AKI patients and found that continuous therapy was associated with lower 90-day mortality and similar kidney outcomes.
A large nationwide cohort study reveals that patients with hematological malignancies and other immunosuppressive conditions have significantly higher risks of ICU-acquired infections, while those with solid tumors do not show increased inc
A randomized clinical trial demonstrates that adding intraoperative dobutamine to norepinephrine during surgical source control for septic shock significantly decreases postoperative acute kidney injury incidence and severity.
This study develops and evaluates prognostic models combining clinical and toxicity information to predict complicated outcomes in ICU patients with acute intoxication, demonstrating the added value of laboratory data over toxicity scores a
Continuous automatic cuff pressure monitoring significantly lowers ventilator-associated pneumonia incidence in critically ill children by ensuring better pressure control, offering an effective preventive strategy in pediatric intensive ca
The ReCCLAIM II trial demonstrates that rapid systemic hypothermia during mechanical thrombectomy for large-vessel occlusion stroke is feasible without delaying reperfusion, showing trends toward reduced infarct volume but raising safety co
A randomized clinical trial compared three high-flow nasal cannula weaning protocols in critically ill adults, finding no significant differences in success rates or weaning duration across flow reduction, FiO2 reduction, and simultaneous r
A 2026 expert consensus recommends shorter, individualized antibiotic courses for most severe infections in critically ill patients, with clear exceptions and guidance on biomarkers, source control, and stewardship.
This study reveals that elevated 12,13-diHOME levels, reflecting brown adipose tissue activation during targeted temperature management after cardiac arrest, correlate with improved survival and distinct immunometabolic profiles.
