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This study reveals heterogeneous clinical phenotypes in mild-to-moderate COPD, demonstrating significant variability in exacerbation risk and lung function decline, emphasizing precision medicine for early intervention.
This phase 3 trial shows that tarlatamab combined with durvalumab significantly improves overall and progression-free survival compared to durvalumab alone as maintenance therapy post-first-line chemoimmunotherapy in extensive-stage small-c
The PANKU-Lung01 phase 3 trial demonstrates izalontamab brengitecan significantly extends progression-free survival compared to platinum-based chemotherapy in EGFR-mutated advanced non-squamous NSCLC after failure of third-generation EGFR T
This article explores the role of the macrophage YTHDC1/TIGAR/NF-κB axis in pulmonary hypertension and highlights its potential as a therapeutic target to mitigate inflammation-driven vascular remodeling.
This trial shows that a six-month eHealth-guided exercise program significantly improves peak oxygen uptake and mental health quality of life in adults recovering from COVID-19, outperforming standard physical activity advice.
New research proposes clear, patient-anchored criteria for defining chronic cough control, highlighting that fewer patients achieve true cough relief than previously thought, underscoring the need for improved therapies.
The phase 3 SAFFRON trial demonstrated that osimertinib combined with savolitinib significantly improves progression-free and overall survival versus platinum-pemetrexed chemotherapy in advanced EGFR-mutated NSCLC harboring MET overexpressi
This study identifies key organizational, social, and individual determinants affecting lung cancer screening follow-up in community settings, highlighting strategies to improve adherence and optimize mortality benefits.
A deep learning model identifying ARDS features on chest X-rays independently predicts 28-day mortality and ventilator duration beyond traditional clinical measures in patients undergoing invasive mechanical ventilation.
This study highlights the diagnostic value of endobronchial optical coherence tomography (EB-OCT) as a complementary, low-risk imaging modality that improves confidence and diagnostic accuracy in interstitial lung disease multidisciplinary
This article explores the surprising presence of conscious respiratory unpleasantness and dyspnea in adults with congenital central hypoventilation syndrome (CCHS) despite severely impaired central CO2 chemosensitivity, revealing potential
Prolonged intubation, rather than tracheostomy placement, is associated with poorer neurodevelopmental outcomes in infants with severe bronchopulmonary dysplasia, highlighting the need to reassess timing of airway interventions.
This review synthesizes current evidence on subsolid nodules (SSNs) and ground-glass opacities (GGOs), focusing on their natural history, treatment strategies including ablation and surgery, survival outcomes, and mortality causes. It highl
This review explores barriers and facilitators influencing research participation among Black and Hispanic/Latino(a) individuals with cystic fibrosis (CF), highlighting systemic inequities, racialized experiences, and community-centered sol
The FIBRONEER-ILD trial demonstrates nerandomilast’s potential to slow lung function decline and reduce mortality in patients with autoimmune-related progressive pulmonary fibrosis, with a favorable safety profile.
A 20-year observational study reveals near-universal long-term proton pump inhibitor use in lung transplant recipients without demonstrable improvements in graft function or survival, challenging routine PPI prescriptions in this population
Women with bronchiectasis face unique reproductive challenges, particularly those with primary ciliary dyskinesia (PCD). Pregnancy often involves exacerbations, but neonatal outcomes remain generally favorable with proper pulmonary care.
Racial disparities in respiratory tract infection diagnoses partially explain lower antibiotic prescribing rates in non-White patients, highlighting the need for equitable clinical assessment and antibiotic stewardship.
This study reveals that clarithromycin modulates inflammatory cytokines in community-acquired pneumonia, identifying distinct immune endotypes that may guide personalized immunomodulatory therapy.
A randomized clinical trial compared three high-flow nasal cannula weaning protocols in critically ill adults, finding no significant differences in success rates or weaning duration across flow reduction, FiO2 reduction, and simultaneous r
