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MASLD has become a leading cause of liver transplantation in the US, with increasing transplant volumes and younger recipients. Despite relative stabilization in growth, survival post-transplant has improved, highlighting evolving epidemiol
This study develops and prospectively validates a simple endoscopic classification of fundoplication integrity that reliably predicts pathological gastroesophageal reflux post-antireflux surgery, correlating with functional and clinical out
Analysis of 1,983 high-certainty DILI cases over two decades reveals shifting drug causes, declining severity, increased herbal and oncology-related cases, and higher mortality among elderly, patients with chronic liver disease, and oncolog
This review synthesizes evidence establishing Days at Home within 90 days (DAH-90) after gastrointestinal cancer surgery as a valid, meaningful patient-centered outcome, integrating survival, morbidity, and healthcare utilization to optimiz
A pivotal Phase 2 study demonstrates that derazantinib yields meaningful responses and progression-free survival in FGFR2-aberrant advanced intrahepatic cholangiocarcinoma, with an acceptable safety profile, supporting its role as a targete
Combining serum leucine-rich alpha-2-glycoprotein 1 (LRG-1) with citrulline offers a sensitive, noninvasive biomarker strategy for early detection and monitoring of rejection in intestinal transplantation, potentially reducing reliance on i
The STOPS trial demonstrates noninferiority of subtotal colectomy with cecorectal anastomosis compared to total colectomy with ileorectal anastomosis for refractory slow-transit constipation at 1 year, balancing symptom relief with postoper
The PIONIR randomized crossover trial demonstrates that a specific Tasty&Healthy diet significantly reduces fecal calprotectin levels, a marker of gut inflammation, in first-degree relatives at high risk for Crohn’s disease, sugge
Saroglitazar, a dual PPAR α/γ agonist, demonstrated significant biochemical improvement and ALP normalization in primary biliary cholangitis patients refractory or intolerant to UDCA, with favorable safety over 52 weeks in a phase 2b/3 tria
A large Swedish cohort study reveals that dental diseases and tooth loss are associated with increased risk of primary liver cancer, highlighting the importance of oral health in systemic disease prevention.
This study analyzes the incidence and clinical consequences of pancreatic fistulas and intra-abdominal fluid collections following distal pancreatectomy, highlighting their management and the impact of surgical drain placement.
This phase 1b study of miricorilant, a selective glucocorticoid receptor modulator, shows significant reductions in liver fat and improvements in liver health markers in patients with presumed metabolic dysfunction-associated steatohepatiti
This article explores how acquired resistance to gemcitabine in pancreatic cancer leads to metabolic reprogramming that creates a vulnerability in the mevalonate pathway, offering a promising therapeutic target.
This article explores how dietary alginate fiber enhances mucosal healing through a microbiota-driven taurine pathway, evidenced by preclinical models and translational clinical insights in ulcerative colitis.
A Swedish cohort study reveals increased risk of inflammatory bowel disease in relapsing-remitting multiple sclerosis patients treated with rituximab compared to other therapies and the general population, underscoring the need for gastroin
Alcohol-associated hepatitis (AH) carries high morbidity and mortality, with no approved therapies addressing both liver injury and alcohol misuse. This article explores integrated trial designs using composite endpoints combining liver and
A pediatric IBD patient’s medication denial due to lack of pediatric FDA labeling prompted physician-led advocacy, resulting in a state law mandating insurance coverage for pediatric medications with adult approval and supporting data
This study explores how microbiome compositions differ in patients with foregut anastomotic leaks managed endoscopically versus surgically, highlighting nutrition and microbial patterns as key factors influencing healing.
This article analyzes global liver transplantation disparities relative to cirrhosis and chronic liver disease burden, revealing unequal access dominated by high-income countries and highlighting the role of health system development in tra
This article reviews a multicenter study comparing outcomes of different treatment approaches for gastric cancer patients with positive peritoneal cytology (CY1) and/or localized peritoneal metastasis (P1a), highlighting the superior surviv
