Section
New international recommendations position imaging as a context-driven adjunct in polymyalgia rheumatica (PMR): not routine for clear cases, most helpful in intermediate or atypical presentations, and not recommended for routine monitoring.
A multicenter RCT demonstrates that a standardized clinical pathway for platelet-rich plasma therapy improves 12-month pain and function outcomes with fewer adverse events in early knee osteoarthritis compared to conventional care.
This study identifies a CCL20+ macrophage subpopulation as a major source of TNF in axial spondyloarthritis synovium, driven by CD40L and an IL-1β/TNF-α autocrine loop, providing insights into disease pathogenesis and therapeutic targets.
A 10-year follow-up of early rheumatoid arthritis patients treated with a treat-to-target strategy shows sustained remission leads to lasting clinical, structural, and functional benefits, supporting current treatment guidelines.
This study reveals sustained elevations in inflammatory and cartilage metabolism serum biomarkers during the first year after ACL reconstruction, indicating ongoing joint biological responses beyond surgery and rehabilitation.
This study reveals that dual BAFF-APRIL blockade with telitacicept distinctly remodels pathogenic autoantibodies in antiphospholipid syndrome, showing differential effects across immunoglobulin isotypes and identifying marrow plasma-cell cl
This article explores distinct immune cell activations in ACPA-positive individuals progressing to rheumatoid arthritis, emphasizing type I interferon activity prior to ultrasound-detectable synovitis and subsequent inflammatory shifts mark
This study quantifies the risk and identifies predictors for systemic lupus erythematosus development in children presenting with skin-limited discoid lupus erythematosus, highlighting the importance of early monitoring especially in patien
Integrated proteomic and metabolomic profiling of TMJ disease reveals nonlinear progression, molecular heterogeneity, and identifies distinct subtypes, offering a new framework for precision diagnosis and targeted therapies.
This study identifies specific DNA methylation patterns in blood that differentiate gout patients from those with asymptomatic hyperuricaemia and normouricaemic controls, linking epigenetic changes to immune-metabolic genetic risk factors a
This prospective nationwide study identifies baseline peripheral blood UBA1 variant allele frequency as a robust predictor of poor outcomes in VEXAS syndrome, providing a new tool for risk stratification and management.
A real-world Japanese study finds comparable 24-month treatment persistence between reduced and standard dosing of JAK inhibitors in rheumatoid arthritis patients with preserved renal function, with dose considerations influenced by poor pr
The FIBRONEER-ILD trial demonstrates nerandomilast’s potential to slow lung function decline and reduce mortality in patients with autoimmune-related progressive pulmonary fibrosis, with a favorable safety profile.
This phase 3 trial shows garetosmab significantly reduces new heterotopic bone lesions and is generally well tolerated in adults with fibrodysplasia ossificans progressiva (FOP), an ultra-rare and disabling genetic disorder.
Enhanced lipolysis in synovial fibroblasts marks early pathogenic changes in individuals at risk for rheumatoid arthritis, indicating metabolic shifts precede clinical disease onset.
A pilot double-blind RCT suggests that adding a single ultrasound-guided dextrose prolotherapy injection to therapeutic exercise moderately improves shoulder pain and function in adults with subacromial-subdeltoid bursitis.
Lonvoguran ziclumeran, an in vivo CRISPR-based single-dose gene-editing therapy, significantly reduces hereditary angioedema attacks and demonstrates a favorable safety profile, marking a transformative advance in treatment.
In EGPA patients unresponsive to mepolizumab, switching to benralizumab improves lung function, reduces glucocorticoid use, and shows a favorable safety profile, suggesting its potential as an effective alternative treatment.
High-impact physical activity in patients with hip osteoarthritis is associated with a reduced 12-month risk of total hip replacement, without increasing knee replacement risk in knee OA patients. Functional capacity partly mediates this be
A six-month supervised telerehabilitation programme combining Pilates-based exercises and self-myofascial release significantly improved fibromyalgia impact, sleep quality, depressive symptoms, and stress levels compared to usual care in ad
