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The clinical briefing

Medical news

8,171 articles

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Impact of CYP2D6 and CYP2C19 Genetic Variations on Venlafaxine Treatment Outcomes: Insights from Norwegian and UK Cohorts

This article reviews a large retrospective study revealing significant associations between CYP2D6 and CYP2C19 genotypes and venlafaxine treatment failure, highlighting the potential for genotype-guided personalized antidepressant therapy.

Oct 17, 2026
Cardiology

Impact of Prolonged Inotropic Use on Outcomes During VA ECMO Support in Cardiogenic Shock

Higher cumulative inotropic exposure during VA ECMO support in cardiogenic shock is associated with increased risk of ECMO weaning failure, mortality, arrhythmias, and delayed lactate clearance, highlighting the need for prospective trials

Oct 17, 2026
Internal Medicine

Enhancing Internal Medicine Resident Efficiency through Outpatient Documentation Standardization: Effects on Time, Note Quality, and Burnout

Standardizing outpatient documentation significantly reduces internal medicine resident time spent on EHR tasks and excessive note lengths, with modest improvements in burnout measures despite no broad well-being changes observed.

Oct 17, 2026
Hematology-Oncology

Innovative Anticoagulation: Targeting Factor XI with Amrecibart and Cenvacibart for Safer Thrombosis Prevention

Factor XI-targeted antibodies, amrecibart and cenvacibart, offer promising anticoagulation by selectively inhibiting intrinsic coagulation pathways, potentially reducing thrombosis without increasing bleeding risk.

Oct 17, 2026
Infectious Diseases

Amikacin Liposome Inhalation Suspension in Newly Diagnosed Mycobacterium avium Complex Lung Disease: Phase 3b ENCORE Trial

The ENCORE trial demonstrates that amikacin liposome inhalation suspension combined with multidrug therapy improves respiratory symptoms and culture conversion in newly diagnosed Mycobacterium avium complex lung disease patients.

Oct 17, 2026
news

When Is High-Level Disinfection Needed for Reusable Ophthalmic Devices? A Multisociety Position Paper Explained

A multisociety task force finds routine high-level disinfection (HLD) of reusable ophthalmic devices unnecessary in most clinics, recommends targeted HLD only for higher-risk encounters, and urges alignment of regulations with evidence.

Oct 17, 2026
news

Inducible Laryngeal Obstruction in Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders: Clinical Correlates and Predictors

This study explores the association between inducible laryngeal obstruction (ILO) and symptoms in patients with hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSD), highlighting chronic cough, dysphagia, and

Oct 17, 2026
General Surgery

De-escalating Axillary Surgery in Early Breast Cancer: Implementing SOUND and INSEMA Trials in Clinical Practice

Omission of sentinel lymph node biopsy (SLNB) in select postmenopausal patients with early HR+/HER2- breast cancer and negative axillary ultrasound is feasible and safe, reducing surgical morbidity without compromising short-term outcomes.

Oct 17, 2026
news

Enhancing Neonatal Respiratory Adaptation After Late-Preterm Cesarean Delivery: The Role of Antenatal Oxytocin and Dexamethasone

Antenatal oxytocin combined with dexamethasone significantly improves respiratory adaptation and reduces adverse outcomes in late-preterm lambs delivered by cesarean section, highlighting potential novel preventive strategies for neonatal r

Oct 17, 2026
Gastroenterology

Targeting IMPDH2-Induced Guanine Nucleotide Depletion to Enhance KRAS Inhibition in Pancreatic Cancer

An integrated genomic and pharmacologic analysis identifies IMPDH2 as a key vulnerability in KRAS-mutant pancreatic cancer, showing that irreversible guanine nucleotide depletion potentiates KRAS-targeted therapies and offers a novel combin

Oct 17, 2026
Clinical Updates

Plasma Phosphorylated Tau 217 Percentage by Race and Ethnicity in Preclinical Alzheimer Disease: Implications for Screening and Biomarker Utility

This review synthesizes evidence on racial and ethnic differences in plasma phosphorylated tau 217 (%p-tau217) in preclinical Alzheimer disease, highlighting implications for diagnostic screening and biomarker validity across diverse popula

Oct 17, 2026
Diabetes & Endocrinology

Exploring the Link Between Mild Autonomous Cortisol Secretion and Psychiatric Disorders in Patients With Adrenal Tumors

A large cohort study reveals that patients with mild autonomous cortisol secretion (MACS) in adrenal tumors are at increased risk for psychiatric disorders, highlighting the need for integrated psychiatric assessment in this population.

Oct 17, 2026
Cardiology

Prominent V Waves in Heart Failure with Preserved Ejection Fraction: Unveiling Their Impact on Right Ventricular Afterload and Pulmonary Vascular Assessment

Prominent left atrial V waves in heart failure with preserved ejection fraction significantly increase right ventricular afterload independent of pulmonary vascular disease, challenging current hemodynamic assessments and impacting patient

Oct 17, 2026
Cardiology

Optimizing Step Counts and Intensity to Reduce Mortality Risk: Insights from UK Biobank Accelerometer Data

This study reveals that various combinations of daily step counts and stepping intensity independently reduce all-cause and cardiovascular mortality, highlighting the importance of personalized physical activity strategies.

Oct 17, 2026
Neurology

Impact of Time-Varying Social Integration on Mortality Following Traumatic Spinal Cord Injury: Insights from the SCIMS Longitudinal Study

This study reveals that lower and declining social integration significantly increase long-term mortality risk after traumatic spinal cord injury, highlighting critical social determinants alongside clinical factors.

Oct 17, 2026
news

Unveiling the Role of Primary Cilia and CEP164 Overexpression in Ameloblastoma Pathobiology

This study reveals that ameloblastomas uniquely maintain primary cilia and exhibit CEP164 overexpression, highlighting a distinct molecular signature that may influence tumor behavior and offer new diagnostic and therapeutic avenues.

Oct 17, 2026
Clinical Updates

Survodutide Once Weekly in Adults with Obesity and Type 2 Diabetes: A Contemporary Review of Evidence and Clinical Implications

Survodutide, a dual glucagon and GLP-1 receptor agonist, demonstrates significant weight loss and glycemic improvements in adults with obesity and type 2 diabetes, offering promise as a novel therapeutic agent with favorable efficacy and sa

Oct 17, 2026
news

Enhancing Rehabilitation Outcomes Through Sense of Coherence: Insights From a 3-Year Longitudinal Study

This longitudinal study highlights how baseline Sense of Coherence and its changes over time impact health and functioning outcomes in rehabilitation patients, suggesting targeted interventions may improve recovery.

Oct 16, 2026
news

Evaluating the Impact of a Digital Companion App in Periodontal Therapy: Insights from a Multi-Center Randomised Controlled Trial

A multi-center RCT assessing the adjunctive use of the Paro-ComPas app in periodontal care found no significant overall benefit, though moderate app engagement showed potential for improved plaque control.

Oct 16, 2026
Neurology

Adjuvant Radiotherapy Reduces Recurrence After Complete Resection of WHO Grade 2 Atypical Meningioma: Insights from the ROAM/EORTC-1308 Phase 3 Trial

The ROAM/EORTC-1308 trial demonstrates that adjuvant radiotherapy after complete surgical resection of atypical meningioma significantly improves 5-year disease-free survival, reducing recurrence risk with manageable adverse effects.

Oct 16, 2026
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