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The clinical briefing

Medical news

8,171 articles

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Oncology

Evaluating Benmelstobart With or Without Anlotinib as Consolidation Therapy After Chemoradiotherapy in Unresectable Stage III NSCLC: Insights from the R-ALPS Trial

The R-ALPS randomized trial confirms that benmelstobart improves progression-free survival in unresectable stage III NSCLC patients post-chemoradiotherapy, while adding anlotinib does not significantly enhance efficacy and raises severe tox

Nov 6, 2026
Rehabilitation Medicine

Dynamic Pitch Count and Velocity Changes Linked to Arm Injuries in Collegiate Baseball Pitchers

This study reveals that increased pitch counts relative to individual averages and reductions in fastball velocity are significantly associated with higher risks of shoulder and elbow injuries among collegiate baseball pitchers during a sum

Nov 6, 2026
Rehabilitation Medicine

Innovative Robotic Assessment Unveils Prevalent Thumb Proprioceptive Deficits Post-Stroke

A novel robotic tool, SomatoCircleJump, demonstrates reliable and sensitive detection of thumb proprioception impairments in chronic stroke survivors, revealing higher prevalence and close relation to finger deficits compared to traditional

Nov 6, 2026
Dentistry

Interpretable Machine Learning Model for Stratifying Periodontitis Severity Using Routine Blood Biomarkers

A machine learning model using common blood tests, age, sex, and smoking status moderately distinguishes severe from mild periodontitis, highlighting potential but necessitating further validation before clinical use.

Nov 6, 2026
Cardiology

Evaluating Immediate Ambulatory ECG Monitoring for Unexplained Syncope: Insights from the ASPIRED Trial

The ASPIRED trial showed that 14-day ambulatory ECG monitoring after unexplained syncope in the emergency department did not significantly reduce syncope recurrence compared to standard care over one year.

Nov 6, 2026
Neurology

Breaking the Ion Channel Dogma: How Capsaicin’s Non-Canonical TRPV1–SSR4 Axis Suppresses Microglial Neuroinflammation

Introduction Neuroinflammation, orchestrated primarily by microglial activation, remains a core pathological driver across neurodegenerative condition

Nov 6, 2026
Ophthalmology

Cloudbreak Pharma Reports Positive Top-Line Phase 3 Data for CBT-001 in Pterygium Treatment

Cloudbreak Pharma Inc. (HKEX: 2592), a clinical-stage ophthalmic biopharmaceutical company specializing in proprietary Multi Kinase Inhibitor (MKI) di

Nov 6, 2026
Dentistry

Comparative Clinical Performance and Color Matching of One-Shade vs. Multi-Shade Flowable Composites in Non-Carious Cervical Lesions: An 18-Month Double-Blind Randomized Trial

This 18-month double-blind randomized trial compared one-shade and multi-shade flowable composites for restoring non-carious cervical lesions, demonstrating comparable clinical performance and objective color match, with multi-shade composi

Nov 5, 2026
Oncology

Izalontamab Brengitecan in Heavily Pretreated HR+/HER2- Breast Cancer: Insights from the PANKU-Breast01 Phase 3 Trial in China

This review details the phase 3 PANKU-Breast01 trial evaluating izalontamab brengitecan versus chemotherapy in pretreated HR+/HER2- breast cancer, highlighting significant PFS improvement and safety considerations in a Chinese cohort.

Nov 5, 2026
Neurology

Long-Term Clinical Outcomes of Zika-Related Microcephaly: Insights from the First Five Years of Life

This article reviews a cohort study characterizing the clinical features, complications, and developmental challenges in children with Zika-related microcephaly during the first five years after birth, highlighting the severity and scope of

Nov 5, 2026
Rheumatology

Comparative Real-World Effectiveness and Retention of Biologic DMARDs in Psoriatic Arthritis: Insights from an Emulated Multicentre Trial

This study evaluates the six-month effectiveness and long-term retention of TNF, IL-17, and IL-23 inhibitors in psoriatic arthritis, revealing comparable efficacy and persistence across biologic classes and highlighting disease duration as

Nov 5, 2026
Transplantation

Rising Trends and Outcomes of MASLD in Liver Transplantation: Implications for Early Detection and Management

MASLD has become a leading cause of liver transplantation in the US, with increasing transplant volumes and younger recipients. Despite relative stabilization in growth, survival post-transplant has improved, highlighting evolving epidemiol

Nov 5, 2026
Plastic Surgery

Predictors and Outcomes of Complications in Retroauricular Interpolated Flaps Following Mohs Surgery: Insights from a Large Retrospective Study

This study examines 417 retroauricular interpolated flap repairs after Mohs surgery, identifying stage-specific complication rates and risk factors such as diabetes and defect size to inform surgical risk management.

Nov 5, 2026
Plastic Surgery

Conjoined Twin Separation and Reconstruction: Anatomical Classification, Surgical Strategies, and Outcomes from a Tertiary Pediatric Center

A novel anatomical classification system from Texas Children’s Hospital aids in assessing conjoined twin separation feasibility, guiding surgical planning, and improving outcomes through structured reconstruction strategies.

Nov 5, 2026
Psychiatry

The Unbroken Integrative Psycho-Trauma Care Model: Scaling Trauma-Informed Mental Health Services in Wartime Ukraine

This article details the implementation and clinical outcomes of the Unbroken Integrative Psycho-Trauma Care Model, a coordinated multidisciplinary approach delivering trauma-informed mental health care at scale within a civilian hospital s

Nov 5, 2026
Critical Care

Analyzing Variability in Pediatric ECPR Survival After In-Hospital Cardiac Arrest: Development and Validation of a Risk-Standardized Survival Model

A validated clinical model predicting survival after pediatric extracorporeal cardiopulmonary resuscitation reveals significant inter-hospital outcome variability, underscoring the importance of risk-standardized benchmarking in pediatric i

Nov 5, 2026
Neurology

Evaluating Blood-Based Biomarkers GFAP and UCH-L1 for Diagnosing Intracranial Injury in Mild Traumatic Brain Injury Patients in the Emergency Department

This study validates plasma biomarkers GFAP and UCH-L1 as sensitive but nonspecific tools to help rule out intracranial injury in mild traumatic brain injury patients, potentially improving emergency department efficiency while highlighting

Nov 5, 2026
Psychiatry

Tailoring Pain Self-Management for Patients with Chronic Pain and Opioid Use Disorder: Insights from Patients and Clinicians

This qualitative study explores how pain self-management interventions can be specifically tailored for patients with co-occurring chronic pain and opioid use disorder, addressing barriers and facilitators identified by patients and clinici

Nov 5, 2026
Hematology-Oncology

Decoding Post-CD7 CAR-T EBV-Positive Lymphoproliferative Disorder: Insights from Multi-Omics and Spatial Profiling

This article explores how CD7 CAR-T therapy leads to EBV-positive lymphoproliferative disorder by revealing CD7-negative T cell dysfunction, immunosuppressive macrophage niches, and EBV-driven B cell transformation through multi-omic techno

Nov 5, 2026
Critical Care

Navigating Uncertainty: The Future Impact of Artificial Intelligence in Critical Care through Ten Paradigms

This article explores how AI could transform critical care by illustrating potential benefits, harms, and ethical challenges through ten parables, guiding clinicians and policymakers in preparing for AI’s integration amid uncertainty.

Nov 5, 2026
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  4. 04Cardiology

    Precision Medicine for Long QT Syndrome Type 2: Lumacaftor Corrects Trafficking Defects and Shortens QT Interval

  5. 05General Surgery

    Optimizing Postoperative Opioid Prescriptions After Intra-Abdominal Cancer Surgery: Comparing the 5x-Multiplier and 3-Tier Models

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