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This review synthesizes recent evidence on the neuroprotective effects of healthy dietary patterns (Mediterranean, MIND), the synergistic impact of lifestyle and pharmacotherapy (GLP-1), and systemic advances in acute stroke care and second
A comprehensive review of a multicenter RCT (Morone et al., 2026) demonstrating that exoskeleton-based robot-assisted therapy significantly improves upper limb motor impairment and clinical outcomes in the early subacute phase of stroke rec
This clinical update synthesizes evidence on Roseburia inulinivorans, identifying it as a species-specific gut microbe that enhances muscle strength by modulating amino acid metabolism and skeletal muscle fiber types.
A randomized clinical trial published in JAMA Psychiatry reveals that yoga as an adjuvant to buprenorphine significantly shortens opioid withdrawal stabilization time and restores autonomic balance, offering a neurobiologically informed str
Systematic review evidence suggests manual therapy with exercise moderately improves function and reduces pain in chronic neck pain compared with no treatment; benefits versus placebo are less clear, highlighting need for further trials and
In a randomized, blinded trial of 74 mechanically ventilated ICU patients, adding early NMES to an early mobilization program started within 48 hours improved functional status, independence, mobility, and quality of life up to 6 months aft
A pragmatic multicenter randomized trial found that coach-supported, home-based multimodal prehabilitation before elective noncardiac surgery did not reduce 30-day postoperative disability or in-hospital complications in older adults with f
A 24‑week, community-based multicomponent frailty intervention in rural Korea was associated with 6.5 additional months free from death or long‑term care eligibility and ~$7,700 per-person NHIS savings over 66 months, suggesting durable cli
A randomized trial in adults with moderate–severe cannabis use disorder found 12 weeks of supervised HIIT did not improve a composite MRI measure of hippocampal integrity versus strength/resistance training; exercise participation was feasi
A double-blind randomized trial (PISCES) found daily fish-oil (EPA+DHA) 4 g reduced serious cardiovascular events by 43% versus corn-oil placebo in patients on maintenance hemodialysis over 3.5 years.
In a prospective Beijing cohort (BLINDSCE), each additional hour of daily sedentary time was associated with a 1.18-point lower baseline intrinsic capacity and a 0.48-point greater decline over 1 year, suggesting sedentary behavior is a mod
A meta-analysis of 36 RCTs (n=2,500) found aerobic exercise significantly reduces depressive symptoms in people with chronic illness (Hedges’ g -0.73). A weekly dose of ≈405 MET‑min (≈120–135 min of moderate aerobic activity) reaches
A pooled prospective analysis of 18,935 hips found severe pincer morphology (LCEA ≥45°) was associated with a 1.5-fold higher odds of incident radiographic hip osteoarthritis within 8 years; moderate pincer (LCEA ≥40°) showed no overall ass
Compositional analysis of the PedCARE cohort suggests that an early period of relative rest combined with above-average light and moderate-to-vigorous activity over the first two weeks is associated with lower postconcussion symptom burden
A multicenter 2×2 factorial RCT in 266 critically ill adults shows that in‑ICU resistance training improves discharge physical function, muscle mass, patient‑reported outcomes, and lowers 6‑ and 12‑month mortality; HMB supplementation produ
Caffeine boosts sports performance but may impair sleep quality, especially when consumed later in the day. Individualized strategies balancing caffeine intake and sleep hygiene can optimize athlete performance and recovery.
A practical, evidence-focused synthesis of 73 international consensus statements and position stands (Delany et al., 2025). Key takeaways: individualise targets, protect health (EA ≥30 kcal/kg FFM/day), use gradual rates, prioritise protein
Hamstring injuries mainly occur during the late swing phase of running due to high eccentric forces and neural factors. Eccentric training reduces injury risk through complex muscle adaptations involving contractile, non-contractile, and ne
Exploring altered cardiopulmonary dynamics and exercise intolerance in adolescents post-sport-related concussion reveals attenuated cardiovascular responses independent of aerobic deconditioning, highlighting autonomic dysregulation as a ke
In 917 Boston Marathon registrants, higher habitual running volume and more quality sessions in the year preceding the race — paired with a relative reduction in training frequency in the last four months — were associated with faster race
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