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Mortality and Morbidity After Below-Knee Amputation in Diabetes: Insights from a 25-Year English Cohort Study
Diabetes & Endocrinologydiabetesbelow-knee amputation

Mortality and Morbidity After Below-Knee Amputation in Diabetes: Insights from a 25-Year English Cohort Study

By MedXY|Sep 17, 2026

This large-scale England study reveals persistently high mortality after below-knee amputation in diabetes, with one-year mortality exceeding 23%, emphasizing the need for targeted interventions focused on older, female, and comorbid patien

Charcot Neuro-Osteoarthropathy in Diabetes: High Risk of Hospitalization, Amputation, and Mortality Revealed by Regional Cohort Study
Diabetes & Endocrinologysurvivaldiabetes

Charcot Neuro-Osteoarthropathy in Diabetes: High Risk of Hospitalization, Amputation, and Mortality Revealed by Regional Cohort Study

By MedXY|Sep 5, 2026

Charcot neuro-osteoarthropathy (CNO) in people with diabetes is linked to frequent emergency hospitalizations, substantial risk of limb amputation, and reduced survival, highlighting urgent need for intensified multidisciplinary care.

Maxillary Distraction Osteogenesis: A Transformative Approach in Cleft Lip and Palate Management
newsOcclusal normalizationOrthognathic surgery

Maxillary Distraction Osteogenesis: A Transformative Approach in Cleft Lip and Palate Management

By MedXY|Sep 3, 2026

Maxillary distraction osteogenesis (MaxDO) offers promising long-term dentofacial correction in cleft lip and palate patients, serving both as a bridge to and replacement for traditional orthognathic surgery.

Assessing Age-Related Risks in Facelift Surgery: Is Chronological Age a Barrier?
newsage-related riskfacelift surgery

Assessing Age-Related Risks in Facelift Surgery: Is Chronological Age a Barrier?

By MedXY|Sep 2, 2026

A decade-long single-surgeon study finds facelift surgery safe across all age groups, including patients older than 75, with no significant increase in major or minor complications attributable to age alone.

Hidden Costs of Healing: Financial Burdens After Distal Upper Extremity Nerve Injuries
newsfinancial burdennerve injury

Hidden Costs of Healing: Financial Burdens After Distal Upper Extremity Nerve Injuries

By MedXY|Sep 2, 2026

Despite nearly universal insurance coverage, nearly half of patients with distal upper extremity nerve injuries face significant financial hardship, influenced by injury location, surgical complexity, and preexisting debt. Targeted financia

Surgical Arthrodesis Versus Watchful Waiting in Hallux Rigidus: Insights from a Landmark Randomized Controlled Trial
newsarthrodesismetatarsophalangeal joint

Surgical Arthrodesis Versus Watchful Waiting in Hallux Rigidus: Insights from a Landmark Randomized Controlled Trial

By MedXY|Aug 12, 2026

First MTPJ arthrodesis significantly reduces walking pain at 12 months in hallux rigidus patients compared with watchful waiting, demonstrating a clinically meaningful benefit in this common foot osteoarthritis.

Acute Neural Biomarker Elevations After Amateur Soccer Heading: Insights Into Potential Brain Injury
NeurologyHead InjuryNeural Biomarkers

Acute Neural Biomarker Elevations After Amateur Soccer Heading: Insights Into Potential Brain Injury

By MedXY|Jul 14, 2026

This study reveals that even amateur soccer heading causes immediate, transient increases in blood biomarkers p-tau217 and S100B, indicating acute neural impact and suggesting a dose-response effect.

Personalizing Osteoporosis Treatment: Integrating Pharmacotherapy with Patient-Centered Lifestyle Strategies
Diabetes & EndocrinologyShared decision makingosteoporosis

Personalizing Osteoporosis Treatment: Integrating Pharmacotherapy with Patient-Centered Lifestyle Strategies

By MedXY|Aug 18, 2026

This article explores personalized osteoporosis management, combining evidence-based pharmacologic therapies with individualized lifestyle and nutrition guidance, to improve patient outcomes through shared decision making.

Impact of Constitutively Active TSH Receptor Mutations on Craniofacial and Bone Morphology in Hyperthyroid Mouse Models
Diabetes & Endocrinologybone mineral densitycraniofacial morphology

Impact of Constitutively Active TSH Receptor Mutations on Craniofacial and Bone Morphology in Hyperthyroid Mouse Models

By MedXY|Jun 24, 2026

This study demonstrates that hyperthyroidism driven by constitutively active TSH receptor mutations alters craniofacial structure and bone mineral density in mice, offering insights into thyroid hormone’s role in skeletal development.

Can Prehabilitation Reduce Complications After Spinal Fusion in Older Adults? What a New Randomized Trial Suggests
newsERASolder adults

Can Prehabilitation Reduce Complications After Spinal Fusion in Older Adults? What a New Randomized Trial Suggests

By MedXY|Jun 19, 2026

A multicenter randomized trial found that 4-week multimodal prehabilitation added to ERAS reduced 90-day complications after spinal fusion in adults aged 75 years or older.

General SurgeryMorel-Lavallee lesionsoft tissue injury

Postoperative Outcomes of Morel-Lavallée Injuries and Predictive Factors for Wound Complications

By MedXY|Jun 18, 2026

A multicenter trauma study found that 20.1% of surgically treated Morel-Lavallée lesions developed wound complications. Pedestrian-versus-vehicle injury was the only independent predictor of postoperative problems.

Restoring Physiology After Upper Extremity Amputation: What the First Human AMI Reconstruction Experience Suggests
newsagonist-antagonist myoneural interfaceamputation

Restoring Physiology After Upper Extremity Amputation: What the First Human AMI Reconstruction Experience Suggests

By MedXY|Jun 19, 2026

A small human cohort study suggests that upper extremity amputation with AMI reconstruction is feasible and may preserve residual limb volume, improve muscle mechanics, and reduce pain and phantom limb symptoms.

Patient Preference Phenotypes for Post-operative Anticoagulation After Hip or Knee Replacement
newsanticoagulationconjoint analysis

Patient Preference Phenotypes for Post-operative Anticoagulation After Hip or Knee Replacement

By MedXY|Jun 2, 2026

A survey study found three distinct patient preference patterns for anticoagulation after hip or knee replacement: clot-prevention focused, balanced, and cost-focused. These differences may help personalize postoperative blood thinner choic

Patient Preference Phenotypes for Post-operative Anticoagulation After Hip or Knee Replacement: A Cross-sectional Survey Study
newsanticoagulationconjoint analysis

Patient Preference Phenotypes for Post-operative Anticoagulation After Hip or Knee Replacement: A Cross-sectional Survey Study

By MedXY|Jun 2, 2026

A survey study found three distinct patient preference patterns for anticoagulation after hip or knee replacement, highlighting the importance of shared decision-making based on clot risk, bleeding risk, and cost.

Chronic Low Back Pain: Physical Therapy Outperforms CBT as First-Line Treatment
Internal Medicinechronic low back painCognitive Behavioral Therapy

Chronic Low Back Pain: Physical Therapy Outperforms CBT as First-Line Treatment

By MedXY|Apr 27, 2026

A recent randomized trial found PT modestly improved function over CBT in cLBP, but no second-stage treatment differences emerged for nonresponders. The study informs adaptive treatment strategies.

Optimizing Anabolic Therapy: A Comparative Analysis of 3-Month vs. 12-Month Romosozumab Regimens in Postmenopausal Osteoporosis
Clinical Updatesbone mineral densityosteoporosis

Optimizing Anabolic Therapy: A Comparative Analysis of 3-Month vs. 12-Month Romosozumab Regimens in Postmenopausal Osteoporosis

By MedXY|Mar 10, 2026

This review analyzes the LIDA trial findings, demonstrating that an abbreviated 3-month romosozumab course followed by denosumab is non-inferior to the standard 12-month regimen in increasing total hip bone mineral density, potentially redu

Abbreviated Romosozumab Regimens in Postmenopausal Osteoporosis: A Review of the LIDA Trial and the Shift Toward Precision Anabolic Dosing
Clinical Updatesbone mineral densityclinical trials

Abbreviated Romosozumab Regimens in Postmenopausal Osteoporosis: A Review of the LIDA Trial and the Shift Toward Precision Anabolic Dosing

By MedXY|Mar 10, 2026

This review evaluates the LIDA trial’s findings that 3 months of romosozumab followed by denosumab is non-inferior to 12 months of romosozumab, offering a cost-effective strategy to mitigate long-term side effects.

Challenging the ‘More is Better’ Paradigm: Intensive Training Shows No Added Benefit in Recent Spinal Cord Injury
Neurologyclinical trialsneuroplasticity

Challenging the ‘More is Better’ Paradigm: Intensive Training Shows No Added Benefit in Recent Spinal Cord Injury

By MedXY|Mar 9, 2026

A Phase 3 pragmatic trial found that 12 hours of weekly intensive task-specific training added to usual care does not improve motor recovery in recent spinal cord injury patients, suggesting a potential plateau in the benefits of early reha

Minimally Invasive Endoscopic Techniques Redefine Recovery in Infraclavicular Brachial Plexus Management
Neurologyendoscopic transsphenoidal surgeryPhẫu thuật chỉnh hình

Minimally Invasive Endoscopic Techniques Redefine Recovery in Infraclavicular Brachial Plexus Management

By MedXY|Mar 8, 2026

Recent clinical evidence demonstrates that endoscopic and arthroscopic techniques for infraclavicular brachial plexus neurolysis and pectoralis minor release provide comparable outcomes to open surgery with significantly reduced morbidity f

Diacerein Fails to Outperform Placebo in Patients with Inflammatory Phenotype Knee Osteoarthritis
newsclinical trialknee osteoarthritis

Diacerein Fails to Outperform Placebo in Patients with Inflammatory Phenotype Knee Osteoarthritis

By MedXY|Mar 2, 2026

A multicenter randomized trial shows diacerein provides no clinical benefit over placebo for knee pain in patients with MRI-confirmed inflammation, despite its theoretical role as an IL-1β blocker.

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