Section
This study evaluates the safety and effectiveness of onabotulinumtoxinA doses above 400 units for upper and lower limb spasticity, showing no new safety concerns and suggesting clinical benefits.
Gain-of-function variants in PLAAT4 define a novel autosomal dominant leukodystrophy characterized by spastic paraplegia and spinal cord white matter abnormalities, with arachidonic acid-related lipids as potential biomarkers.
Regular exercise in midlife women moderates age-related cognitive decline, particularly in processing speed and demanding working memory tasks, with resistance training showing unique benefits for reaction time.
This qualitative study reveals empowerment as central to promoting safer mobility in Parkinson’s disease, emphasizing individualized, contextual, and collaborative strategies for fall prevention.
Eating difficulty is associated with broader functional vulnerability and cognitive decline, rather than directly triggering dementia, highlighting its importance in comprehensive geriatric assessment beyond dental health screening.
This study tracks executive function trajectories from age 2 to 13 in very preterm children, revealing enduring difficulties compared to full-term peers and highlighting the need for early and ongoing interventions, particularly accounting
A randomized clinical trial demonstrates that a self-guided internet intervention significantly reduces seizure frequency and improves anxiety in adults with functional seizures, offering a scalable treatment alternative to standard care.
This study compares the effectiveness of inpatient rehabilitation facilities and skilled nursing facilities on functional recovery after acute stroke, showing inpatient care offers greater long-term home time.
Two phase 3 trials establish remibrutinib, a BTK inhibitor, as more effective and better tolerated than teriflunomide in relapsing multiple sclerosis, supporting its potential as a new oral treatment.
A long-term follow-up of the SPRINT trial shows no significant difference in recurrent stroke or mortality rates between initial low and moderate fixed doses of hydroxyurea in sickle cell disease, emphasizing event clustering within the fir
US emergency departments increasingly discharge transient ischemic attack patients with extensive imaging, reflecting a shift from inpatient to expedited outpatient evaluation, raising questions about cost, feasibility, and rural healthcare
The RCBI trial demonstrates that targeted interventions beginning prior to release and continuing postrelease significantly reduce recidivism and improve coping and executive function in incarcerated men with traumatic brain injury.
The LAST-long trial investigated a community-based, individualized stroke intervention and found that age—but not frailty—significantly modifies its effectiveness, with older stroke survivors (≥80 years) experiencing less favorable outcomes
Hydrocephalus is a multifaceted neurological disorder caused by cerebrospinal fluid imbalance. This review explores current surgical treatments, emerging technologies, molecular mechanisms, and challenges in managing hydrocephalus effective
This review synthesizes evidence from the PROOF-HD placebo arm and related studies, demonstrating that antidopaminergic medication use in Huntington disease correlates with accelerated decline in functional, motor, and cognitive outcomes, e
A clinician-led computer vision system enables accurate, feasible, and usable postural assessment in acquired brain injury rehabilitation, demonstrating significant alignment with clinical evaluations and motion capture data.
This feasibility RCT demonstrates that the HOPE4ABI digital intervention is acceptable and beneficial for improving mental, sexual wellbeing, and quality of life in stroke and brain injury survivors, warranting a definitive efficacy trial.
This study evaluates the sustainment of brief behavioral insomnia treatments in VA primary care mental health clinics after implementation support ended, showing increased therapy delivery and reduced sleep medication prescriptions.
A pharmacovigilance study using EudraVigilance data highlights potential safety signals linking desogestrel-only and drospirenone-only hormonal therapies with meningioma, underscoring the need for further longitudinal research and cautious
This article reviews a 13-year longitudinal study assessing blood-based biomarkers’ effectiveness in predicting all-cause dementia among community-dwelling older adults, highlighting their modest sensitivity and enhanced predictive value wh
