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This study highlights how HPV and TP53 molecular subtyping in stage I vulvar squamous cell carcinoma delineates survival outcomes and recurrence risks, supporting its role in personalized management strategies.
Recent randomized trials show no survival benefit of RhD-positive whole blood over component therapy in trauma, underscoring the need to protect reproductive potential by prioritizing RhD-negative transfusions and follow-up.
This article offers clinicians an evidence-based guide to hormonal options for managing perimenopause, highlighting the distinct physiology, symptom spectrum, and individualized treatment strategies including contraceptives and alternative
This study reveals the population prevalence and incident risk of HPA-1a alloimmunisation in pregnancy across diverse ethnic groups, highlighting its rarity and establishing a framework for risk assessment in foetal-neonatal alloimmune thro
This secondary analysis of the REPAIR study identifies prolonged active second stage labor, deep tears, and physician involvement in suturing as risk factors for perineal wound complications, while prophylactic antibiotics reduce this risk.
This Swedish cohort study reveals growing gestational diabetes prevalence with marked disparities by social determinants such as education, income, and nativity, underscoring the need for targeted prevention and equitable care.
This study examines how episiotomy type influences the risk of obstetric anal sphincter injury during operative vaginal deliveries, highlighting mediolateral episiotomy’s protective effect in women without prior vaginal birth and risk
Five-year data from KEYNOTE-826 confirm pembrolizumab combined with chemotherapy as a durable, first-line treatment improving survival in persistent, recurrent, or metastatic cervical cancer without new safety concerns.
Initiation of menopausal hormone therapy during perimenopause or early postmenopause in women with vasomotor symptoms is associated with a reduced cardiovascular risk, especially among Black women and those starting therapy within 10 years
This multicenter study reveals that total-body irradiation (TBI) conditioning before hematopoietic stem cell transplantation severely compromises pregnancy outcomes compared to alkylating agents or conventional chemotherapy in female surviv
This study reveals distinct alterations in the type I interferon pathway expression and signaling linked to mutated p53 subtypes in endometrial cancer, highlighting differing immune microenvironments that impact prognosis and therapeutic co
This retrospective study compares oncologic and perioperative outcomes of minimally invasive radical hysterectomy without uterine manipulator versus open radical hysterectomy in early-stage cervical cancer, showing comparable survival but i
Large-scale proteomic analysis identifies novel maternal plasma protein biomarkers that improve detection of fetal death beyond established markers, highlighting both shared and unique pathological pathways with preeclampsia.
This Shanghai cohort study reveals that higher parental vitamin B12 and maternal postconception RBC folate levels associate with significantly lower birth defect prevalences, highlighting novel nutritional targets beyond maternal folic acid
Uterine surgery before first pregnancy is associated with increased risks of preterm birth and stillbirth, with risk magnifying after repeated procedures, highlighting the need for careful surgical decision-making and enhanced antenatal mon
This review synthesizes current evidence on the impact of continuing psychostimulant treatment during pregnancy on postpartum mental health outcomes among people with ADHD, highlighting key findings and clinical implications from recent lar
This feasibility study compares cervical screening at 6 and 12 weeks postnatal, assessing uptake, test performance, and patient experience, revealing high concordance and supporting early postnatal screening with some limitations for urine
The ICIQ-PPHSAQ questionnaire demonstrates robust validity and reliability for assessing pelvic floor dysfunction symptoms and risk factors during the perinatal period, supporting its application in English pelvic health services.
This study evaluates cardiovascular and bone health outcomes after bilateral oophorectomy during benign hysterectomy in postmenopausal women, highlighting increased risk for cardiovascular predisposition but no rise in clinical cardiovascul
Routine third-trimester ultrasound screening for suspected large-for-gestational-age fetuses shows limited accuracy, leads to increased obstetric interventions, and does not improve neonatal outcomes, suggesting a need for more individualiz
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