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A large-scale analysis estimates the U.S. national burden of severe hemolytic disease of the fetus and newborn (HDFN) caused by anti-D, anti-K, and anti-c alloantibodies, revealing that severe HDFN is rare despite common alloimmunization.
Regular exercise in midlife women moderates age-related cognitive decline, particularly in processing speed and demanding working memory tasks, with resistance training showing unique benefits for reaction time.
A randomized trial shows that intraoperative Lugol’s iodine staining during LEEP increases positive resection margins and should not be routinely applied, despite reducing postoperative bleeding duration.
This large cohort study demonstrates that biologic therapy in pregnant women with psoriasis is not associated with increased adverse pregnancy outcomes and may reduce risks of spontaneous abortion and gestational diabetes.
This study evaluates the societal cost-effectiveness of oral antihyperglycemic agents compared to insulin for gestational diabetes treatment, showing oral agents offer comparable benefits at potentially lower costs with small quality-adjust
A New Zealand RCT demonstrates that self-assessment with low sensitivity urine pregnancy tests after early medical abortion improves complete follow-up and successful abortion rates compared to serum bhCG testing, supporting safer, equitabl
A pharmacovigilance study using EudraVigilance data highlights potential safety signals linking desogestrel-only and drospirenone-only hormonal therapies with meningioma, underscoring the need for further longitudinal research and cautious
This trial reveals that IVF significantly improves live birth rates compared to surgery in women with ultrasound-diagnosed deep or ovarian endometriosis-related infertility.
Menopausal hormone therapy remains the most effective treatment for estrogen deficiency symptoms, with a favorable benefit-risk profile when individualized by age, timing, and formulation. Emerging evidence refines safety perceptions, guidi
The I-SPY2.2 trial evaluated rilvegostomig combined with trastuzumab-deruxtecan in high-risk ERBB2-negative early breast cancer, showing promising pathologic complete response rates in immune-positive tumors while reducing exposure to anthr
Surgical randomized trials in gynecologic oncology revolutionize treatment approaches, but sustainability beyond publication requires structured implementation, credentialing, and vigilant post-trial surveillance to maintain safety, equity,
This study evaluates adherence to NCCN guidelines and taper durations of corticosteroids in managing severe immune-related adverse events (irAEs) among gynecologic cancer patients receiving immune checkpoint inhibitors, revealing that guide
This review synthesizes current evidence on low-carbohydrate diets in gestational diabetes mellitus (GDM), highlighting effects on glycemia, nutrient adequacy, and perinatal outcomes from the DiGest trial and supporting literature.
This study reveals that prior hemithyroidectomy increases the risk of gestational hypothyroidism and later gestation complications, including preterm birth or pregnancy loss, underscoring the need for vigilant thyroid monitoring during preg
This prospective Scottish study compares cytology and high-risk HPV testing performance in young HPV-vaccinated women, revealing high negative predictive value but lower positive predictive value of hrHPV testing, emphasizing the role of cy
Recent substantial preoperative weight loss (>10%) in obese patients undergoing reduction mammoplasty is associated with increased surgical site infections and hospital readmissions compared to weight-stable obese patients, highlighting
Immunotherapy use in older patients with advanced endometrial cancer has increased over recent years but remains lower among the oldest and racial minorities, highlighting persisting treatment disparities.
This study reveals bidirectional mediation between BMI and inflammatory markers affecting embryo quality and availability in PCOS women undergoing ART, highlighting BMI’s predominant role.
Women with bronchiectasis face unique reproductive challenges, particularly those with primary ciliary dyskinesia (PCD). Pregnancy often involves exacerbations, but neonatal outcomes remain generally favorable with proper pulmonary care.
A randomized clinical trial shows prenatal phosphatidylcholine supplements support fetal brain development, reducing early childhood social withdrawal and improving cognitive performance without significant safety concerns.
