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Combined measurement of LDL-C, lipoprotein(a), and hsCRP improves long-term prediction of atherosclerotic cardiovascular disease in a multiethnic cohort, highlighting important ethnic differences in absolute ASCVD risk.
This multicenter retrospective study shows that GLP-1 receptor agonists improve glycemic control and cardiometabolic parameters with good tolerance in heart transplant recipients with type 2 diabetes, supporting their therapeutic role in th
Anticoagulation therapy in adults aged 80 and older with atrial fibrillation is linked to reduced all-cause mortality despite an increased risk of gastrointestinal bleeding, supporting its continued use in selected elderly patients.
This multicenter study reveals that among HLHS subtypes, mitral stenosis and aortic atresia with ventriculocoronary connections have the poorest transplant-free survival, highlighting the prognostic importance of prenatal and postnatal VCC
Cardiovascular risk prediction models show limited accuracy in postmenopausal women with chronic kidney disease, often underestimating risk, highlighting the need for improved tools in this high-risk population.
This article explores the role of the macrophage YTHDC1/TIGAR/NF-κB axis in pulmonary hypertension and highlights its potential as a therapeutic target to mitigate inflammation-driven vascular remodeling.
The DANCODE trial demonstrates that combined vitamin K2 and D3 supplementation reduces the progression of severe coronary artery calcification over 24 months without increasing noncalcified plaque burden, offering a promising adjunctive str
A 12-week metyrapone regimen lowers blood pressure and reduces epicardial fat in patients with mild autonomous cortisol secretion, suggesting cardiovascular improvements without altering cardiac morphology or function.
This review elucidates the contrasting roles of ACADM-mediated fatty acid β-oxidation in atherosclerosis and abdominal aortic aneurysm, highlighting differential lipid metabolism and translational implications for diagnosis and therapy.
This study explores myocardial external efficiency (MEE) and mitochondrial function in heart transplant recipients, revealing improved MEE at 6 months post-transplant associated with myocardial contractility and biomarkers, highlighting ene
A significant brachial-to-radial arterial pressure gradient occurs in nearly one-fifth of critically ill patients receiving vasoactive agents, correlating with higher vasoactive doses, greater illness severity, and increased ICU mortality.
Initiating cholesterol-lowering therapy during childhood in familial hypercholesterolaemia substantially reduces LDL-C burden and cardiovascular risk, highlighting the importance of early diagnosis and treatment.
The SMART-REACH2 model estimates lifetime recurrent cardiovascular risk and benefits of preventive treatment in patients with established atherosclerotic cardiovascular disease, offering region-specific recalibration and supporting personal
This article evaluates the presence of micro- and nano-plastics in coronary blood of patients with ischemic heart disease, linking their burden to acute coronary events, air pollution exposure, and inflammation, highlighting a novel environ
This secondary analysis of the SirPAD trial shows that sirolimus-coated balloon angioplasty significantly reduces 1-year target-lesion revascularization rates compared to uncoated balloons in femoropopliteal artery disease patients without
This multicenter study reveals that nearly 60% of cervical artery dissection patients achieve complete vessel recanalization at 6 months. Older age, diabetes, smoking, and initial complete occlusion markedly reduce recanalization odds, with
A landmark randomized trial demonstrates that atorvastatin reduces major cardiovascular events in adults aged 70 and older without established cardiovascular disease but does not extend disability-free survival, highlighting nuanced conside
Elevated baseline CRP levels in older acute HF patients identify those who gain the most physical function improvement from a 12-week rehabilitation program, supporting biomarker-guided therapy.
The DASH4D diet, a diabetes-adapted version of the DASH eating plan, significantly improves blood pressure and blood sugar control in type 2 diabetes with hypertension, offering a strong evidence-based dietary recommendation for personalize
This study reveals that familial hypercholesterolaemia accelerates thymic ageing, reducing thymic output and altering T-cell diversity; statin therapy partially preserves thymic function, suggesting integrated metabolic-immunologic manageme
