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This review synthesizes current evidence on the frequency and risk factors of cystoid macular edema (CME) after cultured human corneal endothelial cell (cHCEC) injection, highlighting prostaglandin analog use as a key associated factor and
Postacute discharge to inpatient rehabilitation facilities (IRF) after acute ischemic stroke (AIS) is associated with a reduced 1-year risk of major adverse cardiovascular events (MACE) compared to discharge to home or skilled nursing facil
This review synthesizes evidence identifying critical programmatic factors, relational dynamics, and interventions enhancing hospice transitions in cancer palliative care, emphasizing collaborative oncology-palliative care relationships and
This review synthesizes longitudinal evidence linking early adulthood vascular risks, particularly elevated systolic blood pressure and smoking, to midlife cognitive decline and brain structural alterations. It highlights critical intervent
The effectiveness of lifestyle interventions promoting physical activity for diabetes risk reduction varies by prediabetes phenotype, with individuals having impaired fasting glucose showing the least response. Tailored approaches may enhan
Early initiation of methadone take-home dosing (5-24 weeks post-induction) reduces mortality and treatment discontinuation, surpassing benefits seen with no take-home dosing. Flexible dosing policies improve retention without increasing ove
Digitalis glycosides reduce cardiovascular death or worsening heart failure events in HFmrEF and HFrEF patients over a median of 36–37 months, supported by randomized trials and meta-analyses highlighting their role in select heart failure
This review synthesizes current evidence on germline lymphoma-predisposing variants, highlighting their impact on earlier cancer onset and variable survival rates in pediatric lymphoma patients, underscoring implications for genetic screeni
Earlier initiation of biologic therapies in severe asthma improves clinical remission rates, reduces exacerbations, preserves lung function, and decreases corticosteroid dependence, supporting a shift from reserving to preserving treatment
This review summarizes the progression risk from mild-to-moderate to severe asthma based on the NORDSTAR cohort and integrates emerging evidence on biologic therapies that improve severe asthma outcomes across diverse patient profiles.
This review synthesizes emerging evidence from the PROACT trials on genotype-first identification of subclinical coronary atherosclerosis using polygenic risk scores (PRS), highlighting feasibility, engagement, and high prevalence of silent
Rapid immunoassay-based classifiers accurately identify hyper- and hypoinflammatory subphenotypes in critically ill children, preserving prognostic and predictive utility and enabling precision therapies in acute pediatric cardiorespiratory
Pediatric mental health ED visits in the US have surged 2016-2022, exhibiting volume-dependent disparities in patient demographics and diagnoses, highlighting opportunities for tailored interventions to enhance care across diverse emergency
Astegolimab, an anti-ST2 monoclonal antibody, significantly reduced moderate/severe exacerbations in COPD patients with frequent exacerbations in pooled ALIENTO and ARNASA analyses, showing promise for targeting the IL-33/ST2 pathway with g
Emerging evidence links high pesticide exposure events (HPEEs) in farmers to increased self-reported olfactory dysfunction, though objective smell testing yields inconclusive associations, highlighting critical gaps and methodological consi
This review synthesizes evidence on IL-16-driven resistance to BTK inhibitors and chemoimmunotherapy in B-cell lymphomas, highlighting the IL-16/CD9/PI3K axis as a targetable epigenetically regulated survival pathway overcoming drug resista
Vulvar cancer exhibits significant recurrence rates, predominantly local, with survival declining sharply after recurrence. Awareness of recurrence-associated symptoms enhances early detection. Surgery remains pivotal in management, with fr
This review explores evidence linking smoking and exhaled carbon monoxide levels to reduced Parkinson’s disease risk, emphasizing a potential protective role of carbon monoxide, supported by recent large-scale cohort data and biologic
This review examines the role of FreeStyle Libre Pro iQ CGM in differentiating presymptomatic stages of type 1 diabetes and predicting progression to clinical disease, comparing its performance with Dexcom G6 and discussing implications for
This review synthesizes evidence linking aspirin use to reduced risk of calcific aortic valve disease in persons with elevated lipoprotein(a), highlighting the potential for targeted preventive strategies.
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