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Sustained VEGF-A suppression via the Port Delivery System with ranibizumab effectively resolves diabetic macular edema with most patients achieving edema normalization; slow resolution may mimic treatment unresponsiveness, warranting reclas
This study evaluates the safety of sodium-glucose cotransporter 2 inhibitors (SGLT2is) versus DPP-4 inhibitors in adults aged 75 and older with type 2 diabetes, demonstrating favorable safety outcomes for SGLT2is without increased harm.
A novel RMR equation specific to elite cyclists improves energy expenditure estimation, supporting personalized nutrition and athletic performance optimization.
This multicenter retrospective study shows that GLP-1 receptor agonists improve glycemic control and cardiometabolic parameters with good tolerance in heart transplant recipients with type 2 diabetes, supporting their therapeutic role in th
Acmopatide, a novel biased GLP-1/GIP receptor agonist, improves glycemic control and reduces body weight without severe adverse events in overweight adults with type 1 diabetes, based on a 16-week phase 2 randomized trial.
This study evaluates semaglutide’s benefits over dulaglutide or liraglutide among diabetic hemodialysis patients, highlighting improved survival, reduced hospitalizations, and greater weight loss with semaglutide.
This study evaluates the societal cost-effectiveness of oral antihyperglycemic agents compared to insulin for gestational diabetes treatment, showing oral agents offer comparable benefits at potentially lower costs with small quality-adjust
A 12-week metyrapone regimen lowers blood pressure and reduces epicardial fat in patients with mild autonomous cortisol secretion, suggesting cardiovascular improvements without altering cardiac morphology or function.
This phase 1b study of miricorilant, a selective glucocorticoid receptor modulator, shows significant reductions in liver fat and improvements in liver health markers in patients with presumed metabolic dysfunction-associated steatohepatiti
This phase 2 trial demonstrates that once-weekly lonapegsomatropin matches daily somatropin in improving height velocity and safety in children with Turner syndrome over 52 weeks, offering a promising alternative to daily injections.
An interventional study reveals testosterone’s tissue-specific effects on lipid metabolism, highlighting skeletal muscle as a critical site of metabolic disruption in male hypogonadism and its cardiometabolic implications.
Menopausal hormone therapy remains the most effective treatment for estrogen deficiency symptoms, with a favorable benefit-risk profile when individualized by age, timing, and formulation. Emerging evidence refines safety perceptions, guidi
The ARMMS-T2D study identifies key baseline factors predicting remission and relapse of type 2 diabetes after metabolic-bariatric surgery or intensive medical-lifestyle therapy, aiding personalized treatment decisions.
This study elucidates distinct genetic drivers underlying Cushing disease versus silent corticotroph adenomas, revealing mutation and copy-number variation profiles that correlate with their divergent clinical behaviors and aggressiveness.
This review synthesizes current evidence on low-carbohydrate diets in gestational diabetes mellitus (GDM), highlighting effects on glycemia, nutrient adequacy, and perinatal outcomes from the DiGest trial and supporting literature.
This study reveals that prior hemithyroidectomy increases the risk of gestational hypothyroidism and later gestation complications, including preterm birth or pregnancy loss, underscoring the need for vigilant thyroid monitoring during preg
The DASH4D diet, a diabetes-adapted version of the DASH eating plan, significantly improves blood pressure and blood sugar control in type 2 diabetes with hypertension, offering a strong evidence-based dietary recommendation for personalize
A retrospective study reveals that a subset of infants with focal congenital hyperinsulinism experience spontaneous glycemic improvement prior to surgery, suggesting a potential for conservative management in selected cases.
This study examines how effective patient-centered communication by physicians at community health centers supports self-management behaviors in patients with cardiometabolic conditions.
This study reveals bidirectional mediation between BMI and inflammatory markers affecting embryo quality and availability in PCOS women undergoing ART, highlighting BMI’s predominant role.
