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VPS13D protects against alcohol-induced liver injury by maintaining mitochondria-ER contact sites, regulating phospholipid balance and promoting VLDL secretion, thus mitigating steatosis and inflammation in alcoholic hepatitis.
This study explores factors that promote or hinder hospitalized patients’ use of Smart Bedside Station systems, revealing that nursing support and useful video education encourage use, while cognitive and workflow challenges limit sus
KDIGO 2026 updates anemia care in CKD: evidence-based thresholds for iron therapy, preference for IV iron on hemodialysis, ESA-first approach over HIF-PHIs, individualized Hb initiation, and an ESA maintenance upper Hb target <11.5 g/dL.
A randomized trial found telehealth mindfulness group visits improve chronic low back pain more than usual care, highlighting a scalable, non-drug treatment option.
This study evaluates the data quality, variability, and clinical outcomes of inpatient social determinants of health screening across 18 hospitals, revealing important disparities and validating the screening tool’s clinical relevance
A UK prospective cohort study reveals a U-shaped association between hemoglobin concentration and mortality, with both low and high levels linked to increased death risk across age and sex groups.
This pooled analysis of seven multi-ethnic cohorts demonstrates the combined prognostic value of plasma phosphorylated tau 217 concentrations and APOE-ε4 genotype for predicting risk and timing of cognitive impairment, emphasizing biomarker
This study explores how intensivists conceptualize appropriate goals of care and the influences of health system factors on decision-making for patients with chronic critical illness, emphasizing predictions about quality of life and functi
An integrated educational and structural intervention in an internal medicine residency clinic improved residents’ confidence and timely communication of test results, highlighting the importance of aligning education and clinical sys
Cushing’s syndrome in older adults requires a tailored diagnostic approach and individualized management that prioritizes functional status and quality of life over chronological age, accounting for atypical presentations and comorbidities.
Baseline clinical, functional, and psychosocial metrics predict participant attrition in diabetic foot ulcer offloading device trials; integration via risk visualization enhances retention strategies and highlights technology benefits.
Drug-Induced Liver Injury (DILI) remains a pivotal challenge in drug development, with evolving drug modalities and clinical trial designs prompting updated regulatory perspectives from FDA specialists.
Despite identical immunogenetic makeup, half of kidney transplant recipients from identical twins remain on calcineurin inhibitors, with no demonstrable benefit in rejection reduction or graft survival over 25 years, calling for critical re
Individualized coaching using EHR learner analytics significantly improves resident inbasket management efficiency and feedback quality but does not reduce perceived burnout or improve confidence.
The ANDROMEDA phase 3 trial demonstrates that adding subcutaneous daratumumab to VCd therapy markedly improves hematologic and organ responses, leading to better progression-free and overall survival in newly diagnosed AL amyloidosis patien
This study analyzes healthcare usage up to 12 months after COVID-19 infection, revealing prolonged increased utilization—especially among hospitalized patients—highlighting ongoing care needs for survivors.
Alpha-1 antitrypsin deficiency (AATD) Z-allele carriers, including heterozygotes and homozygotes, exhibit progressively increased risk of adverse liver outcomes, emphasizing the need for early diagnosis and vigilant monitoring.
A shift from static portal pressure thresholds to dynamic, non-invasive risk prediction models offers improved prognostic accuracy for decompensation in advanced chronic liver disease, enabling personalized patient management and better cli
The DASH4D diet, a tailored DASH-style intervention for diabetes, significantly improved key glycemic biomarkers including fructosamine, fasting glucose, and HbA1c compared to a typical American diet in adults with type 2 diabetes.
This study reveals distinct sex differences in skeletal muscle inflammation and dysfunction in patients with HFrEF, highlighting divergent immune cell profiles linked to muscle mass and strength variations in men versus women, advancing und
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