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Anticoagulation therapy in adults aged 80 and older with atrial fibrillation is linked to reduced all-cause mortality despite an increased risk of gastrointestinal bleeding, supporting its continued use in selected elderly patients.
This study reveals heterogeneous clinical phenotypes in mild-to-moderate COPD, demonstrating significant variability in exacerbation risk and lung function decline, emphasizing precision medicine for early intervention.
Despite substantial potential revenue, only 15% of US primary care clinicians adopted Medicare’s Advanced Primary Care Management codes in 2025, with administrative challenges as key barriers.
Despite proven benefits, medications for alcohol use disorder remain underprescribed at hospital discharge. This study identifies hospitalization and patient factors influencing new prescriptions, highlighting opportunities to enhance AUD t
A cost consequence analysis demonstrated that guided periodontal infection control (GPIC) is less costly than conventional non-surgical therapy (CNST) while achieving similar periodontal health outcomes at six months.
This study evaluates the sustainment of brief behavioral insomnia treatments in VA primary care mental health clinics after implementation support ended, showing increased therapy delivery and reduced sleep medication prescriptions.
An interventional study reveals testosterone’s tissue-specific effects on lipid metabolism, highlighting skeletal muscle as a critical site of metabolic disruption in male hypogonadism and its cardiometabolic implications.
This study examines characteristics and reasons behind non-attendance to exercise and self-management sessions among multimorbid patients, highlighting younger age, lower self-efficacy, and depressive symptoms as key factors.
The phase 3 VISIONARY trial establishes sibeprenlimab as a promising therapy in IgA nephropathy, significantly stabilizing eGFR decline and reducing kidney-function deterioration over 24 months with a favorable safety profile.
This study investigated how acclimation to dry versus humid heat affects endurance cycling performance and physiological responses, revealing environment-specific and cross-environmental benefits for athletes.
This study identifies specific DNA methylation patterns in blood that differentiate gout patients from those with asymptomatic hyperuricaemia and normouricaemic controls, linking epigenetic changes to immune-metabolic genetic risk factors a
This study examines how the 2016 CDC opioid prescribing guideline influenced opioid and gabapentinoid use in older adults with dementia, revealing shifts in analgesic prescribing patterns but uncertain effects on symptom management.
Alcohol-associated hepatitis (AH) carries high morbidity and mortality, with no approved therapies addressing both liver injury and alcohol misuse. This article explores integrated trial designs using composite endpoints combining liver and
This qualitative study explores practicing physicians’ experiences with humanistic practice, revealing how relationships and resilience foster compassion despite systemic challenges like efficiency demands and standardized care models.
A novel nomogram using pretransplant triglycerides and body weight shows promise to guide early mycophenolate mofetil dosing after kidney transplantation, potentially reducing drug overexposure before therapeutic drug monitoring is feasible
This qualitative study explores how ambient AI scribes affect ambulatory patient experience, revealing improvements in communication, visit thoroughness, and patient comfort influenced by demographic and relational factors.
A comprehensive meta-analysis of six US cohorts identifies vascular risk factors including smoking, hypertension, diabetes, chronic kidney disease, stroke history, and APOE ε4 genotype as significant predictors of late-onset epilepsy in old
An AI-generated panoramic dental imaging score correlates independently with diabetes, hypertension, ischemic heart disease, osteoporosis, and hyperlipidemia, supporting integrated medical-dental care.
Racial disparities in respiratory tract infection diagnoses partially explain lower antibiotic prescribing rates in non-White patients, highlighting the need for equitable clinical assessment and antibiotic stewardship.
The CONNECT trial demonstrates that continuous glucose monitoring (CGM) significantly improves glycemic control in adults with non-insulin-treated type 2 diabetes managed in primary care, reducing HbA1c levels and hyperglycemia risk without
