The clinical briefing
A novel RMR equation specific to elite cyclists improves energy expenditure estimation, supporting personalized nutrition and athletic performance optimization.
A 9-year-old girl with atopic dermatitis and relapsing nephrotic syndrome achieved sustained remission of both conditions after dupilumab therapy, enabling withdrawal of steroids and tacrolimus.
New international recommendations position imaging as a context-driven adjunct in polymyalgia rheumatica (PMR): not routine for clear cases, most helpful in intermediate or atypical presentations, and not recommended for routine monitoring.
This multicenter retrospective study shows that GLP-1 receptor agonists improve glycemic control and cardiometabolic parameters with good tolerance in heart transplant recipients with type 2 diabetes, supporting their therapeutic role in th
This review synthesizes evidence on the characteristic clinical and histopathologic features of condyloma lata in secondary syphilis, emphasizing its reliable recognition to prevent misdiagnosis, especially at extragenital sites.
This study demonstrates that patient-specific virtual mirrored-image planning significantly improves symmetry, globe positioning, malar projection, and psychosocial outcomes compared to traditional intraoperative visual estimation in late r
This study examines differences in effect estimates between cluster-randomized and individually randomized clinical trials in prehospital, emergency, and critical care, revealing systematic bias in length-of-stay outcomes but not mortality.
Anticoagulation therapy in adults aged 80 and older with atrial fibrillation is linked to reduced all-cause mortality despite an increased risk of gastrointestinal bleeding, supporting its continued use in selected elderly patients.
Autoimmune neutropenia (AiN) in adults, though rare, is a chronic condition predominantly affecting women with autoimmune comorbidities. Treatment prioritizes observation, with therapies aimed at boosting neutrophil counts or modulating imm
This study reveals heterogeneous clinical phenotypes in mild-to-moderate COPD, demonstrating significant variability in exacerbation risk and lung function decline, emphasizing precision medicine for early intervention.
A randomized trial demonstrates that using an autologous anterior lens capsule as an intrascleral spacer during deep sclerectomy combined with phacoemulsification lowers intraocular pressure and enhances surgical success in glaucoma patient
This review synthesizes evidence establishing Days at Home within 90 days (DAH-90) after gastrointestinal cancer surgery as a valid, meaningful patient-centered outcome, integrating survival, morbidity, and healthcare utilization to optimiz
A large-scale analysis estimates the U.S. national burden of severe hemolytic disease of the fetus and newborn (HDFN) caused by anti-D, anti-K, and anti-c alloantibodies, revealing that severe HDFN is rare despite common alloimmunization.
A pivotal Phase 2 study demonstrates that derazantinib yields meaningful responses and progression-free survival in FGFR2-aberrant advanced intrahepatic cholangiocarcinoma, with an acceptable safety profile, supporting its role as a targete
Gain-of-function variants in PLAAT4 define a novel autosomal dominant leukodystrophy characterized by spastic paraplegia and spinal cord white matter abnormalities, with arachidonic acid-related lipids as potential biomarkers.
Acmopatide, a novel biased GLP-1/GIP receptor agonist, improves glycemic control and reduces body weight without severe adverse events in overweight adults with type 1 diabetes, based on a 16-week phase 2 randomized trial.
This multicenter study reveals that among HLHS subtypes, mitral stenosis and aortic atresia with ventriculocoronary connections have the poorest transplant-free survival, highlighting the prognostic importance of prenatal and postnatal VCC
A multicenter RCT demonstrates that a standardized clinical pathway for platelet-rich plasma therapy improves 12-month pain and function outcomes with fewer adverse events in early knee osteoarthritis compared to conventional care.
