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The clinical briefing

Medical news

8,171 articles

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Clinical Updates

Trends in Spending on Corrective Lenses: An Evidence-Based Review on Expenditures, Barriers, and Policy Implications

Corrective lens spending affects nearly 20% of the US population, with half paying fully out-of-pocket, highlighting substantial financial burdens and access barriers. Evidence from clinical trials and epidemiologic studies underscores cost

Oct 19, 2026
news

Enhancing Genetic Discovery in Sensorineural Hearing Loss Through Precision Audiometric Phenotyping

Precision phenotyping using audiometric pure-tone averages enhances genetic variant detection for sensorineural hearing loss compared to diagnostic coding, offering improved heritability estimates and risk prediction to advance hearing heal

Oct 19, 2026
Clinical Updates

Bariatric Surgery and Risk of Obesity-Related Cancer by Age and Sex: A Comprehensive Review

This review synthesizes evidence from large cohort studies and meta-analyses highlighting bariatric surgery’s association with reduced risks of many obesity-related cancers, consistent across age and sex. Mechanistic insights and impl

Oct 19, 2026
news

Predicting Anal Incontinence One Year After Severe Perineal Tears in Primiparous Women: Development and Validation of a Practical Risk Model

A robust multivariable model predicts anal incontinence risk one year postpartum in primiparous women with second- to fourth-degree perineal tears, aiding personalized clinical care.

Oct 19, 2026
Gastroenterology

Identifying Preclinical Crohn’s Disease in High-Risk Individuals Using Faecal Calprotectin: A New Framework for Prevention Trials

A study in asymptomatic first-degree relatives of Crohn’s disease patients defines preclinical stages using faecal calprotectin, offering a targeted screening approach to enrich prevention trial cohorts.

Oct 19, 2026
Neurology

Assessing Early Pregnancy Exposure to Anti-CGRP Monoclonal Antibodies and Propranolol: Implications for Spontaneous Abortion Risk

This study evaluates the association between early pregnancy use of anti-CGRP monoclonal antibodies or propranolol and spontaneous abortion risk, finding increased risk with anti-CGRP mAbs but not with propranolol.

Oct 19, 2026
Diabetes & Endocrinology

Waist Circumference Surpasses Cardiometabolic Indices in Identifying Hypogonadism in Klinefelter Syndrome

This study finds that waist circumference is a better and more practical tool than traditional cardiometabolic indices for detecting hypogonadism in men with Klinefelter Syndrome, enhancing clinical assessment beyond age alone.

Oct 19, 2026
Cardiology

Innovative Early Discharge with Subcutaneous Furosemide for Heart Failure: Enhancing Recovery and Reducing Hospital Stay

A subcutaneous furosemide minipump-enabled early discharge strategy improves days alive and out of hospital in heart failure patients, reducing inpatient stay without increasing serious adverse events significantly.

Oct 19, 2026
news

Evaluating the Safety of High-Grade Percutaneous MCL Pie-Crusting in Medial Meniscus Surgery: Implications for Valgus Stability

High-grade percutaneous medial collateral ligament (MCL) pie-crusting during medial meniscus posterior root tear repair yields improved surgical visualization without causing clinically meaningful postoperative valgus instability.

Oct 19, 2026
Clinical Updates

Long-term Effects of Spinal Cord Stimulation Combined with Physiotherapist-led Exercise and Prescribed Physical Activity in Chronic Neuropathic Pain: A Clinical Review

This review synthesizes evidence on spinal cord stimulation combined with physiotherapist-led exercise and physical activity prescriptions, highlighting sustained pain relief and quality-of-life improvements without significant increases in

Oct 18, 2026
news

Local Factors Influencing Implant-Related Complications: Insights from a Norwegian Population Study

A Norwegian cross-sectional study identifies modifiable local factors, including soft-tissue phenotype and prosthetic design parameters, linked to peri-implantitis and peri-implant soft-tissue dehiscence in dental implants.

Oct 18, 2026
Superintelligence

Evaluating Conversational AI in Urgent Primary Care: A Prospective Feasibility Study of the Articulate Medical Intelligence Explorer

This study assesses the safety, quality, and user acceptance of a conversational AI system aiding urgent primary care by engaging patients before appointments, demonstrating promising feasibility for clinical integration.

Oct 18, 2026
Nursing & care

Navigating Home Care Safety for Children with Medical Complexity: Parental Challenges and Innovations

Parents of children with medical complexity face numerous safety challenges in managing tube-related care at home, developing creative strategies to mitigate risks while often lacking communication with healthcare teams, highlighting the ne

Oct 18, 2026
news

Centralized Expert Review Enhances Diagnostic Accuracy in Axial Spondyloarthritis: Insights from a Multicenter Telemedicine Study

Centralized clinical and imaging evaluation via telemedicine significantly improves diagnostic accuracy in patients suspected of axial spondyloarthritis, reducing misdiagnoses and guiding more precise patient management.

Oct 18, 2026
Hematology-Oncology

Immunosuppression and Long-term Survival After Single Living-donor Lobar Lung Transplantation from the Same Donor as Prior Hematopoietic Stem Cell Transplantation: An All-Japan Case Series

This case series examines immunosuppressive management and long-term outcomes in nine Japanese patients undergoing single living-donor lobar lung transplantation from the same donor as prior HSCT, revealing viable reduced immunosuppression

Oct 18, 2026
Dermatology

Enhancing Diagnostic Sensitivity for Bullous Pemphigoid: The Emerging Role of LABD97 IgG ELISA

LABD97 IgG ELISA significantly improves the detection sensitivity for bullous pemphigoid by identifying more patients with circulating autoantibodies compared to traditional BP180 (NC16A) and BP230 ELISAs.

Oct 18, 2026
news

Impact of Neoadjuvant versus Adjuvant Chemotherapy on Outcomes in Prepectoral Tissue Expander Breast Reconstruction After Mastectomy

This study compares surgical outcomes in prepectoral tissue expander breast reconstruction following mastectomy, revealing that adjuvant chemotherapy increases major complication risks, while neoadjuvant chemotherapy and perioperative leuko

Oct 18, 2026
news

Evaluating Caring Letters for Suicide Prevention Among US Veterans Contacting the Veterans Crisis Line

A secondary analysis found no association between receipt of Caring Letters and reduced suicide mortality among US veterans contacting the Veterans Crisis Line, nor differences by sender type.

Oct 18, 2026
Critical Care

Reevaluating Ventilation Rates During Pediatric CPR: New Insights into Age-Stratified Outcomes

This article explores findings from a multicenter study evaluating the impact of cardiopulmonary resuscitation ventilation rates on survival in pediatric intensive care, identifying age-specific ventilation targets linked to improved outcom

Oct 18, 2026
Hematology-Oncology

Targeting PPM1D Overexpression in Myeloproliferative Neoplasms: Molecular Insights and Therapeutic Advances

PPM1D mutations and overexpression are involved in MPN pathogenesis, with dual PPM1D and HDM2 inhibition emerging as a promising therapeutic strategy, particularly for myelofibrosis patients.

Oct 18, 2026
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    Precision Medicine for Long QT Syndrome Type 2: Lumacaftor Corrects Trafficking Defects and Shortens QT Interval

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    Optimizing Postoperative Opioid Prescriptions After Intra-Abdominal Cancer Surgery: Comparing the 5x-Multiplier and 3-Tier Models

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