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The clinical briefing

Medical news

8,171 articles

Latest updates

Respiratory

Pulse versus Nonpulse Corticosteroid Therapy in Acute Exacerbation of Idiopathic Pulmonary Fibrosis: Evidence Synthesis and Clinical Implications from the SAFER Trial

This review synthesizes current evidence on pulse versus nonpulse corticosteroid therapy in AE-IPF, contextualizing the SAFER trial findings within prior studies and clinical guidelines to guide management and future research.

Oct 18, 2026
Oncology

Long-Term Outcomes of 103Pd Plaque Brachytherapy for Choroidal Melanoma: Insights into Visual Preservation and Ocular Health in the Second and Third Decades

This study reports durable tumor control and meaningful visual preservation up to 20 years after 103Pd plaque brachytherapy for choroidal melanoma, providing valuable long-term data for clinical decision-making.

Oct 18, 2026
news

Wildfire Air Pollution Exposure and Head and Neck Cancer Incidence

This study identifies a link between exposure to wildfire-specific PM2.5 air pollution and increased risks of head and neck cancers over a 10-year period, with notable effects on oral cavity, oropharyngeal, and laryngeal cancers.

Oct 18, 2026
Gastroenterology

PREBOTPilot Trial: Botulinum Toxin Injection Into the Sphincter of Oddi Fails to Prevent Pancreatic Fistula After Distal Pancreatectomy

A randomized controlled trial showed that preoperative botulinum toxin injection into the sphincter of Oddi does not reduce the incidence of clinically relevant postoperative pancreatic fistula following distal pancreatectomy.

Oct 18, 2026
Clinical Updates

Treatment Failure After Laparoscopic Radiofrequency Ablation Compared With Myomectomy: A Comprehensive Review of Current Evidence

This review synthesizes evidence comparing laparoscopic radiofrequency ablation and myomectomy for uterine leiomyomata, highlighting higher treatment failure rates with RFA and identifying predictive factors influencing outcomes.

Oct 18, 2026
Gastroenterology

Unveiling the Role of HtpG-High-Expressing Escherichia coli in Chronic Pancreatitis Fibrosis: Microbiota-Targeted Therapeutic Hope

Identification of a pathogenic E. coli strain overexpressing HtpG that promotes fibrosis in chronic pancreatitis via macrophage-mediated pathways highlights new microbiota-targeted treatment avenues.

Oct 18, 2026
Clinical Updates

Safety and Efficacy of Delpacibart Zotadirsen in Duchenne Muscular Dystrophy Amenable to Exon 44 Skipping: Insights from the EXPLORE44 Phase 1/2 Trial

Delpacibart zotadirsen demonstrates an acceptable safety profile and significant increases in exon 44 skipping and dystrophin expression in DMD patients amenable to exon 44 skipping, supporting further phase 3 evaluation.

Oct 18, 2026
Cardiology

Evaluating Bleeding Risks of Asundexian in Noncardioembolic Ischemic Stroke or High-Risk TIA: Insights from the OCEANIC-STROKE Trial

The OCEANIC-STROKE randomized trial demonstrates that adding asundexian to antiplatelet therapy reduces ischemic stroke without a significant rise in major bleeding, though it increases lower gastrointestinal bleeding in patients with nonca

Oct 18, 2026
Neurology

Elevated Risk of Training-Related Concussions in Elite English Premiership Rugby: Eight-Season Prospective Cohort Analysis

An eight-season study reveals increased concussion incidence during preseason and full-contact training in men’s English Premiership Rugby, emphasizing the need for strategic training modifications to reduce injury risk.

Oct 18, 2026
Clinical Updates

Technical and Clinical Feasibility of a Pulmonary Telerehabilitation Model for People with COPD: A Comprehensive Review

This review synthesizes evidence on the feasibility, acceptance, and clinical outcomes of pulmonary telerehabilitation models in COPD, highlighting technical reliability, patient adherence, and clinical benefits from recent trials, includin

Oct 18, 2026
Dentistry

GLP-1 Receptor Agonists in Dentistry: Exploring Therapeutic Promise Amidst Clinical Uncertainties

GLP-1 receptor agonists exhibit promising osteoprotective and anti-inflammatory effects in preclinical dental studies but lack robust clinical data, underscoring urgent research needs on their oral health impact and safety profile.

Oct 18, 2026
HIV/AIDS

Long-Acting Injectable HIV Therapy: Improving Viral Suppression in African Adults with Adherence Challenges

A Phase 3b trial in eastern and southern Africa showed that long-acting injectable cabotegravir plus rilpivirine is noninferior to oral dolutegravir-based therapy for maintaining viral suppression in HIV patients facing adherence challenges

Oct 18, 2026
OB/GYN & Women's Health

Expanding the Genetic Landscape in Ovarian Carcinoma: Insights from the PERSONA-Ovary Trial on Germline and Somatic Testing

The PERSONA-Ovary trial demonstrates the feasibility and clinical value of unselected germline multigene panel testing alongside somatic BRCA analysis in ovarian carcinoma, revealing a 29.7% pathogenic variant prevalence and optimal testing

Oct 17, 2026Sign in to read
Critical Care

Assessing Muscle Recovery: Responsiveness of the K-Force Grip Dynamometer in ICU-Acquired Weakness Patients

This study confirms the K-Force grip dynamometer as a responsive tool to detect short-term changes in handgrip strength in ICU-acquired weakness patients, supporting its clinical utility in critical care rehabilitation.

Oct 17, 2026
Clinical Updates

Long-Acting Injectable Cabotegravir-Rilpivirine Every 8 Weeks for Adolescents with HIV in Sub-Saharan Africa: Evidence from the LATA Trial and Contemporary Context

The LATA trial demonstrates that long-acting injectable cabotegravir-rilpivirine given every 8 weeks is superior to daily oral ART for maintaining virological suppression in adolescents with HIV in sub-Saharan Africa, with a favorable safet

Oct 17, 2026
news

Optimizing Antibiotic Therapy for Community-Acquired Pneumonia in Children with Medical Complexity: Evidence for Narrow-Spectrum Use

In children with medical complexity hospitalized for nonsevere community-acquired pneumonia, broad-spectrum antibiotics show no advantage over narrow-spectrum agents, supporting targeted aminopenicillin use to improve outcomes and antibioti

Oct 17, 2026
Hematology-Oncology

Phenotype-Specific Mosaic Chromosomal Alterations in Systemic Sclerosis: Implications for Disease Subtypes and Clinical Outcomes

This article explores the differential associations of mosaic chromosomal alterations (mCAs), especially chromosomal loss and mosaic loss of the X chromosome, with systemic sclerosis and its subtypes, revealing phenotype-specific genetic co

Oct 17, 2026
Gastroenterology

Impact of Donor Warm Ischemic Time on Biliary Complications After Laparoscopic Donor Right Hepatectomy: Insights From a Retrospective Cohort Study

Prolonged donor warm ischemia during pure laparoscopic donor right hepatectomy elevates recipient biliary stricture risk, underscoring the need to minimize warm ischemic time for better post-transplant outcomes.

Oct 17, 2026
Dermatology

COMPASS-SCC: A Novel Prognostic and Staging System Enhancing Risk Stratification in Cutaneous Squamous Cell Carcinoma

The COMPASS-SCC, developed from a large international cohort, offers improved prognostic accuracy for cutaneous squamous cell carcinoma compared to existing AJCC8 and BWH staging systems, aiding clinical decision-making for metastasis and m

Oct 17, 2026
news

Impact of Prior Implant-Based Reconstruction and Radiotherapy on Microvascular Outcomes in Delayed DIEP Flap Breast Reconstruction

This study shows that prior implant-based reconstruction combined with radiotherapy increases perioperative microvascular complications but not flap necrosis in delayed DIEP flap breast reconstruction, highlighting increased surgical comple

Oct 17, 2026
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    Precision Medicine for Long QT Syndrome Type 2: Lumacaftor Corrects Trafficking Defects and Shortens QT Interval

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    Optimizing Postoperative Opioid Prescriptions After Intra-Abdominal Cancer Surgery: Comparing the 5x-Multiplier and 3-Tier Models

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