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HPV Positivity in Keratinizing Nasopharyngeal Carcinoma: Implications for Prognosis and Clinical Practice

HPV-positive keratinizing nasopharyngeal carcinoma demonstrates significantly improved overall survival compared to HPV-negative cases, underscoring the prognostic and clinical relevance of HPV testing in NPC management.

Oct 20, 2026
news

Impact of Patient-Level Social Determinants on Colon Cancer Outcomes: A Novel Prognostic Measure Within an Integrated Health Network

A new patient-level social determinants of health measure independently predicts advanced stage and survival outcomes in colon cancer patients, highlighting the importance of integrating social risk factors into oncologic care.

Oct 20, 2026
news

Adjunctive Metformin with Progestin in Fertility-Sparing Treatment of Endometrial Neoplasia: Insights from the FELICIA Trial

The FELICIA phase IIb trial found that adding metformin to progestin therapy for fertility-sparing treatment in endometrial neoplasia did not improve 3-year recurrence-free survival or remission rates, though some reproductive outcomes favo

Oct 20, 2026
news

Online Sports Betting Legalization and Behavioral Health Care Use

Legalizing online sports betting in the US is linked to increased use of outpatient mental health services and prescription medications among insured adults, highlighting the need for focused prevention and treatment.

Oct 20, 2026
Critical Care

Implementing a Provincial Web-Based Family Satisfaction Survey in ICUs: Insights from Ontario’s Quality Improvement Initiative

A province-wide quality improvement initiative in Ontario implemented a web-based Family Satisfaction in ICU (FS-ICU) survey across adult level 3 ICUs, revealing high satisfaction scores yet highlighting challenges in participation and comp

Oct 20, 2026
Cardiology

Adoption of Outpatient Management of Acute Low-Risk Pulmonary Embolism: Evidence, Implementation, and Future Directions

This review synthesizes evidence supporting outpatient management of acute low-risk pulmonary embolism (PE), highlighting risk stratification tools, safety outcomes, and implementation strategies to enhance adoption in clinical practice.

Oct 20, 2026
Internal Medicine

Bridging the Gap: Addressing Low Breast Cancer Screening Rates Among Resident Physicians in Academic Primary Care

Resident physicians demonstrate lower breast cancer screening rates compared to faculty, even in well-supported academic practices. Adjusting for patient and physician factors narrows, but does not eliminate, this gap, underscoring the need

Oct 20, 2026
Hematology-Oncology

Cases of High-Titer Inhibitor Formation After AAV Gene Therapy for Hemophilia A

Two hemophilia A patients developed persistent high-titer FVIII inhibitors following AAV-mediated gene therapy with a bioengineered FVIII transgene despite prior extensive FVIII exposure.

Oct 20, 2026
Neurology

Impact of APOE ɛ4 and ɛ2 Alleles on Cognitive Trajectories in Nonagenarians and Beyond: Insights from the LifeAfter90 Study

This study illuminates how APOE ɛ4 accelerates executive function decline while ɛ2 may protect verbal episodic memory in individuals aged 90+, highlighting genetic influences on cognition in exceptional longevity.

Oct 20, 2026
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Respiratory

Quantitative Computed Tomography in Progressive Pulmonary Fibrosis: Insights from the INBUILD Trial Sub-Study

Quantitative CT imaging offers valuable prognostic information and helps assess treatment response in patients with progressive pulmonary fibrosis, supporting better clinical trial outcomes and therapeutic decisions.

Oct 20, 2026
news

Prognostic Value of 15-GEP/PRAME Assay With or Without Confirmatory Cytopathology in Uveal Melanoma: Insights From the Collaborative Ocular Oncology Group Study 2

This study validates the prognostic accuracy of the 15-gene expression profiling (15-GEP) and PRAME assay in uveal melanoma patients irrespective of confirmatory cytopathology, supporting its use in clinical management when cytopathology is

Oct 20, 2026
Anesthesiology

Cannabis Use and Prolonged Opioid Utilization After Head and Neck Free Flap Reconstructive Surgery: A Clinical Evidence Synthesis

This review evaluates evidence linking perioperative cannabis use to prolonged opioid use and functional outcomes in head and neck cancer patients undergoing free flap reconstruction, emphasizing implications for pain management.

Oct 20, 2026
General Surgery

Navigating Anti-DEI Federal Policies in Academic Surgery: Strategies to Sustain Diversity, Research, and Equity

Federal executive orders restricting DEI initiatives pose significant challenges to academic surgery’s workforce diversity, research integrity, and editorial freedom. Adaptive strategies integrating equity into existing quality and sa

Oct 20, 2026
news

Decoding the Molecular Landscape of Human Labor: Insights Across Cervical Dilatation at Term

This study reveals extensive molecular changes in amniotic fluid proteomes during the execution phase of human labor, highlighting distinct biological processes linked to cervical dilatation stages at term.

Oct 20, 2026
Gastroenterology

Reevaluating EASL 2025 Criteria: Benefits of Nucleos(t)ide Analogues in Chronic Hepatitis B Beyond Current Recommendations

This study demonstrates that nucleos(t)ide analogue therapy significantly reduces cirrhosis and hepatocellular carcinoma risk in specific HBeAg-positive chronic HBV infection phases beyond current EASL 2025 treatment indications.

Oct 20, 2026
Clinical Updates

Global Incidence of All-Cause Dementia: A Comprehensive Meta-Analysis and Contemporary Insights

This review synthesizes global dementia incidence from the COSMIC consortium, highlighting variations by age, sex, and economic regions, with implications for prevention and resource planning, informed by recent meta-analyses on risk factor

Oct 20, 2026
Diabetes & Endocrinology

Sex-Specific Mortality Risk in Type 1 Diabetes: Insights from Recent Decades of Advanced Care

Recent advances in diabetes care have reduced mortality risk in type 1 diabetes, yet females with type 1 diabetes continue to experience disproportionately higher relative mortality compared to males.

Oct 20, 2026
Cardiology

Refining Mitral Regurgitation Assessment in Transthyretin Amyloid Cardiomyopathy: A Multicenter Cohort Study Enhances Prognostic Precision

This study establishes transthyretin amyloid cardiomyopathy-specific mitral regurgitation thresholds, revealing lower severity cutoffs than guidelines and enhancing mortality and heart failure hospitalization risk prediction.

Oct 20, 2026
Clinical Updates

Neoadjuvant Stereotactic Ablative Radiotherapy Prior to Inferior Vena Cava Thrombectomy in Renal Cell Carcinoma: A Synthesis of Emerging Phase 2 Evidence

This review synthesizes phase 2 trial data supporting neoadjuvant stereotactic ablative radiotherapy for RCC with IVC tumor thrombus, highlighting improved recurrence-free survival, acceptable safety, and biomarker insights that underscore

Oct 20, 2026
news

Swimming Plus Education: Short-Term Benefits for Chronic Low Back Pain Management

A randomized trial found that individualized swimming combined with education improves disability in chronic low back pain patients more than education alone, with benefits evident at 8 weeks but not sustained at 1 year.

Oct 20, 2026
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    Optimizing Postoperative Opioid Prescriptions After Intra-Abdominal Cancer Surgery: Comparing the 5x-Multiplier and 3-Tier Models

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