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The clinical briefing

Medical news

8,171 articles

Latest updates

Otorhinolaryngology

Impact of Anxiety and Depression on Patient-Reported Outcomes After Functional and Aesthetic Rhinoplasty

Anxiety and depression negatively influence satisfaction and revision rates after functional septorhinoplasty but do not affect outcomes following aesthetic septorhinoplasty.

Oct 22, 2026
Psychiatry

Understanding Sex Differences in Antipsychotic Treatment Outcomes for Acute Schizophrenia

A comprehensive analysis reveals no significant sex differences in antipsychotic efficacy or dose-response in acute schizophrenia, though females show greater reduction in dropout rates and higher prolactin elevation.

Oct 22, 2026
Critical Care

Optimizing Weaning Strategies from High-Flow Nasal Cannula in Critically Ill Adults: Insights from a Multicenter Randomized Trial

A randomized clinical trial compared three high-flow nasal cannula weaning protocols in critically ill adults, finding no significant differences in success rates or weaning duration across flow reduction, FiO2 reduction, and simultaneous r

Oct 22, 2026
General Surgery

Rethinking Warm Ischemic Time Limits in DCD Organ Donation: Insights from Italy’s Extended No-touch Period Experience

Italian data suggest prolonged warm ischemic times in donation after circulatory death do not compromise kidney and liver transplant outcomes when combined with advanced perfusion techniques, challenging traditional strict cutoffs.

Oct 22, 2026
Hematology-Oncology

Decoding the Genomic and Clinical Impact of RAS Mutations in Acute Myeloid Leukemia

This comprehensive analysis of 8,553 AML patients reveals diverse RAS mutation patterns, their associations with other genomic alterations, and distinct prognostic implications influenced by the genomic context and treatment modalities, gui

Oct 22, 2026
Critical Care

Shorter Is Often Better: Expert Consensus on Antibiotic Duration in Sepsis and Severe Infections in the ICU

A 2026 expert consensus recommends shorter, individualized antibiotic courses for most severe infections in critically ill patients, with clear exceptions and guidance on biomarkers, source control, and stewardship.

Oct 22, 2026
Clinical Updates

Associations Between Routine Vaccinations and the Risk of New-Onset Idiopathic Uveitis: Immune Modulation and Clinical Implications

This review synthesizes evidence linking routine vaccinations, including COVID-19 and herpes zoster vaccines, with reduced risk of new-onset idiopathic uveitis, highlighting immune mechanisms and clinical impacts.

Oct 22, 2026
Neurology

Phase-Dependent Effects of Electrical Stimulation on Bell’s Palsy Recovery: Risks of Early Overuse and Benefits in Chronic Sequelae

This study reveals that aggressive electrical stimulation during acute Bell’s palsy recovery may worsen synkinesis and reduce botulinum toxin efficacy, while chronic-phase stimulation improves function, emphasizing a critical cumulati

Oct 22, 2026
General Surgery

Transforming Kidney Transplant Care: The SETI Operational Redesign Enhances Access and Efficiency

The Semi-Elective Transplant Initiative (SETI) introduces a systems-based approach to deceased-donor kidney transplantation, improving logistics and graft utilization by shifting to proactive scheduling and expanded machine perfusion, witho

Oct 22, 2026
Allergy & Immunology

Decoding Recurrent Implantation Failure: The Role of HSP70-Mediated Macrophage-Stromal Crosstalk in Endometrial Dysregulation

This study uncovers how HSP70-driven inflammatory interactions between macrophages and stromal cells disrupt the endometrial environment, contributing to recurrent implantation failure by impairing decidualization and immune homeostasis.

Oct 22, 2026
Gastroenterology

AASLD EXPO 2026: Modern Role and Recommendations for Liver Biopsy

An expert-practice summary of the 2026 AASLD EXPO on liver biopsy: indications, techniques (percutaneous, transjugular, EUS-guided), sample adequacy, safety thresholds, and emerging applications including molecular profiling and digital pat

Oct 22, 2026
Neurology

Predictive Value of Midlife and Late-Life Blood Biomarkers for Alzheimer’s Disease and Long-Term Cognitive Decline

This study reveals that midlife plasma p-tau181 predicts faster memory decline over 11 years, highlighting a long prodromal phase of Alzheimer’s disease. Late-life biomarkers p-tau181, NfL, and GFAP correlate with accelerated cognitive decl

Oct 22, 2026
Infectious Diseases

Unprecedented Ebola Outbreak Originating in Congo Spreads Across Four Additional Nations

A fast-moving and geographically unprecedented Ebola outbreak that began in the Democratic Republic of the Congo has extended into four additional cou

Oct 21, 2026
Infectious Diseases

Medina County Identifies 18 Measles Cases Across Local Families Amid Persistent Ohio Outbreak

Public health officials in Medina County have detected an uptick in measles infections, confirming 18 total cases linked to a small cluster of familie

Oct 21, 2026
Infectious Diseases

Russia Investigates Suspected Mpox Outbreak Near Moscow as Five Are Hospitalized for Observation

Russian public health authorities have launched an extensive epidemiological investigation and rolled out containment protocols following a suspected

Oct 21, 2026
Infectious Diseases

Mpox Emerges in New Regions: High Impact on Children Sparks Concern as Experts Outline Containment and Prevention

A fresh outbreak of mpox has surfaced in Guinea-Bissau—the country's first recorded cases—bringing the viral infection back into the global spotlight.

Oct 21, 2026
Infectious Diseases

Unconfirmed Plague Suspicions Arise Following Lab Worker's Death in Siberia: What Experts Say

Health authorities worldwide are monitoring the death of a 28-year-old laboratory worker in Siberia, Russia, following reports of an undetermined case

Oct 21, 2026
Critical Care

12,13-diHOME Levels as a Marker of Brown Adipose Tissue Activation and Outcome in Targeted Temperature Management Post-Cardiac Arrest

This study reveals that elevated 12,13-diHOME levels, reflecting brown adipose tissue activation during targeted temperature management after cardiac arrest, correlate with improved survival and distinct immunometabolic profiles.

Oct 21, 2026
Cardiology

Transseptal TMVR Using the SAPIEN M3 System: 1-Year Outcomes in Patients with Mitral Annular Calcification from the ENCIRCLE MAC Registry

Transseptal transcatheter mitral valve replacement with the SAPIEN M3 system in patients with symptomatic mitral annular calcification shows sustained mitral regurgitation reduction, improved functional status, and meaningful quality-of-lif

Oct 21, 2026
news

High-Impact Physical Activity and Joint Replacement Risk in Hip and Knee Osteoarthritis: A Large-Scale Longitudinal Mediation Study

High-impact physical activity in patients with hip osteoarthritis is associated with a reduced 12-month risk of total hip replacement, without increasing knee replacement risk in knee OA patients. Functional capacity partly mediates this be

Oct 21, 2026
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  4. 04Cardiology

    Precision Medicine for Long QT Syndrome Type 2: Lumacaftor Corrects Trafficking Defects and Shortens QT Interval

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    Optimizing Postoperative Opioid Prescriptions After Intra-Abdominal Cancer Surgery: Comparing the 5x-Multiplier and 3-Tier Models

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