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The clinical briefing

Medical news

8,171 articles

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Critical Care

Integrated Respiratory and Functional Training Enhances Weaning and Recovery After Emergency Abdominal Surgery: Insights from a Randomized Controlled Trial

This RCT demonstrates that combining multidimensional functional training with inspiratory muscle training and chest physiotherapy improves weaning success, muscle strength, functional independence, pain reduction, and ICU stay following em

Oct 21, 2026
news

Optimizing Peri-Implant Tissue Dimensions: Timing and Materials in Crestal Soft-Tissue Augmentation

This study demonstrates that prior soft-tissue augmentation using autogenous grafts before flapless implant placement significantly enhances peri-implant tissue dimensions compared to simultaneous augmentation or collagen substitutes, under

Oct 21, 2026
Hematology-Oncology

Ponatinib Plus Blinatumomab vs. Imatinib And Chemotherapy: Advancing Frontline Therapy in Adult Philadelphia-Positive ALL

This phase 3 trial demonstrates that a chemotherapy-free regimen combining ponatinib and blinatumomab significantly improves event-free survival over imatinib plus chemotherapy in adults with Philadelphia chromosome-positive acute lymphobla

Oct 21, 2026
Superintelligence

Predicting Central Serous Chorioretinopathy Outcomes Using Interpretable AI-Driven OCT Biomarkers: Insights from a Multicenter Cohort Study

A multicenter study demonstrates that interpretable machine learning applied to baseline OCT biomarkers accurately predicts chronicity in central serous chorioretinopathy, facilitating early risk stratification and personalized management.

Oct 21, 2026
news

Phenotypic Stratification of Facial Synkinesis Resting States: Implications for Surgical Planning

This study identifies three distinct resting facial synkinesis phenotypes—hypertonic, symmetric, and hypotonic—that can guide targeted static and dynamic surgical treatments to improve patient outcomes.

Oct 21, 2026
Anesthesiology

Evaluating Acute Normovolemic Hemodilution in Women Undergoing Cardiac Surgery: Efficacy, Safety, and Clinical Implications

This secondary analysis of the ANH trial found no significant reduction in allogeneic blood transfusions with acute normovolemic hemodilution in female cardiac surgery patients, but noted increased intraoperative hypotension and longer ICU

Oct 21, 2026
Cardiology

Postpartum Blood Pressure Monitoring After Hypertensive Disorders of Pregnancy Predicts Long-Term Cardiovascular Risk

This cohort study links postpartum blood pressure at 6 weeks following hypertensive pregnancy disorders with a doubled risk of future cardiovascular disease, highlighting a crucial preventive care window.

Oct 21, 2026
Diabetes & Endocrinology

Saroglitazar Shows Promise in Treating Hepatic Steatosis in Women with PCOS and MASLD: Insights from a Multicenter Trial

Saroglitazar significantly improves liver fat content, liver enzymes, and lipid profiles in women with PCOS and MASLD, highlighting its potential as a therapeutic option in this underrepresented population.

Oct 21, 2026
Infectious Diseases

Exploring the Link Between Common Infections and Alzheimer’s Disease Neuropathology: Insights From a UK Prospective Cohort Study

A large-scale UK cohort study found no strong associations between antibodies against multiple common infections and key Alzheimer’s disease neuropathologies, though possible interactions with APOE ε4 genotype and education warrant further

Oct 21, 2026
Cardiology

Second Universal Definition of Heart Failure (2026): Key Changes and Clinical Guidance from the AHA/ACC/ESC/WHF Expert Consensus

The 2026 Second Universal Definition standardizes HF terminology, reframes ejection-fraction categories, formalizes pre-HF and dynamic HF trajectories, and offers a global, cause-based classification to improve prevention, diagnosis, resear

Oct 21, 2026
Gastroenterology

Long-term Outcomes of Neoadjuvant Nivolumab and Ipilimumab in MSI-High Gastric and GEJ Adenocarcinoma: Insights from the Phase 2 NEONIPIGA Trial

The NEONIPIGA phase 2 trial demonstrates durable survival and high pathological complete response rates with neoadjuvant nivolumab and ipilimumab in localized MSI-high gastric and GEJ adenocarcinoma, highlighting potential for organ-preserv

Oct 21, 2026
news

Navigating Alignment Changes After Transphyseal ACL Reconstruction Near Skeletal Maturity: Insights from the PLUTO Study Group

Transphyseal ACL reconstruction in patients close to skeletal maturity generally results in minimal alignment changes, but a significant subgroup shows clinically relevant valgus deformities, underscoring the need for vigilant radiographic

Oct 21, 2026
news

Enhanced Fibromyalgia Management Through Six-Month Supervised Telerehabilitation: Integrating Pilates and Self-Myofascial Release

A six-month supervised telerehabilitation programme combining Pilates-based exercises and self-myofascial release significantly improved fibromyalgia impact, sleep quality, depressive symptoms, and stress levels compared to usual care in ad

Oct 21, 2026
Dentistry

Digitally Guided Root Membrane Preparation Using a Dedicated Apex Guide for Immediate Implant Placement: A Retrospective Case Series

This retrospective case series evaluates the feasibility and 1-year outcomes of using a dedicated Apex Guide with static digital workflow for root membrane preparation and immediate implant placement in 15 patients.

Oct 21, 2026
Gastroenterology

Shortening Sofosbuvir-Velpatasvir Therapy for Non-Cirrhotic Chronic Hepatitis C: Evidence from the RESOLVE Trial in India

The RESOLVE trial demonstrates that 8 weeks of sofosbuvir-velpatasvir treatment is non-inferior to the standard 12-week regimen in treatment-naive, non-cirrhotic chronic hepatitis C patients, supporting shorter treatment duration without co

Oct 21, 2026
news

Assessing Social Risk Screening and Referral Practices in Pediatric Inpatient Care: A National Survey

A national survey reveals wide variability in social risk screening and referral practices across pediatric inpatient settings, highlighting the need for standardized approaches to promote equitable social care for hospitalized children.

Oct 21, 2026
Dermatology

Neutrophil-to-Lymphocyte Ratio as a Prognostic Biomarker in High-Risk Cutaneous Squamous Cell Carcinoma

Preoperative neutrophil-to-lymphocyte ratio (NLR) predicts poor outcomes in high-risk cutaneous squamous cell carcinoma, offering a cost-effective tool to enhance risk stratification.

Oct 21, 2026
news

Durable Long-Term Outcomes of the Modified Liacyr-Ribeiro Technique in Breast Reduction and Mastopexy

The Modified Liacyr-Ribeiro breast reduction technique demonstrates high patient satisfaction and lasting structural outcomes over more than 10 years, effectively preventing inferior pole descent and pseudoptosis.

Oct 21, 2026
news

Deep Learning on CT Scans Enhances Prognostication of Interstitial Lung Abnormalities

A deep learning model classifying usual interstitial pneumonia patterns on CT scans predicts fibrosis progression and mortality in individuals with interstitial lung abnormalities, offering a promising tool for risk stratification and clini

Oct 20, 2026
news

Ocular Metastasis Over Four Decades: Clinical Patterns, Survival, and Therapeutic Outcomes in 569 Patients

A 40-year retrospective study of 569 patients with ocular metastases reveals persistently poor survival, dominated by breast and lung primaries, with vision often preserved through treatment despite no significant survival improvements over

Oct 20, 2026
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    Precision Medicine for Long QT Syndrome Type 2: Lumacaftor Corrects Trafficking Defects and Shortens QT Interval

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    Optimizing Postoperative Opioid Prescriptions After Intra-Abdominal Cancer Surgery: Comparing the 5x-Multiplier and 3-Tier Models

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