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The clinical briefing

Medical news

8,171 articles

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Early Quadriceps Strength Recovery Predicts 2-Year Outcomes After Quadriceps Tendon Autograft ACL Reconstruction

Early postoperative quadriceps strength symmetry strongly predicts patient-reported knee function and satisfaction two years after quadriceps tendon autograft ACL reconstruction, highlighting its role in guiding rehabilitation and assessing

Oct 25, 2026
Neurology

Enhancing Balance and Reducing Dizziness in Chronic Peripheral Vestibular Dysfunction: The Role of Repetitive Transcranial Magnetic Stimulation

A randomized controlled trial reveals that repetitive transcranial magnetic stimulation combined with vestibular rehabilitation significantly improves dizziness, balance, and postural stability in adults with chronic peripheral vestibular d

Oct 25, 2026
Dentistry

Evaluating Soft-Tissue Augmentation in Aesthetic Implant Dentistry: Connective Tissue Graft Versus Volume-Stable Collagen Matrix

This RCT assesses clinical, radiographic, histological, and patient-reported outcomes of soft-tissue augmentation with connective tissue grafts and volume-stable collagen matrices during implant placement in the aesthetic zone.

Oct 25, 2026
Critical Care

Intermittent vs Continuous Renal-Replacement Therapy in Acute Kidney Injury: Insights from a Multicenter Trial

This randomized trial compared intermittent hemodialysis and continuous renal-replacement therapy in critically ill AKI patients and found that continuous therapy was associated with lower 90-day mortality and similar kidney outcomes.

Oct 25, 2026
Cardiology

Clinical Impact of Digoxin Withdrawal in Heart Failure: Insights from the DECISION Trial

The DECISION trial demonstrated that discontinuation of low-dose digoxin in heart failure patients optimized on guideline therapy leads to increased heart failure events and clinical deterioration, supporting cautious withdrawal decisions.

Oct 24, 2026
news

Psychological Readiness as a Predictor of Successful Return to Sports in Adolescents After Patellar Stabilization Surgery

This retrospective study reveals that psychological readiness, measured by ACL-RSI scores, significantly predicts return to sport in adolescent patients after patellar stabilization surgery, overshadowing demographic and surgical factors.

Oct 24, 2026
news

Aquatic Plyometrics: A Breakthrough in Managing Adolescent Patellofemoral Pain Syndrome

Aquatic plyometric exercises significantly improve pain, muscle strength, and quality of life in adolescents with patellofemoral pain syndrome, offering a safe and effective rehabilitation option.

Oct 24, 2026
Superintelligence

AI-Derived Panoramic Radiograph Score Links Oral Health to Major Systemic Diseases

An AI-generated panoramic dental imaging score correlates independently with diabetes, hypertension, ischemic heart disease, osteoporosis, and hyperlipidemia, supporting integrated medical-dental care.

Oct 24, 2026
news

Garetosmab: A Promising Disease-Modifying Antibody for Fibrodysplasia Ossificans Progressiva

This phase 3 trial shows garetosmab significantly reduces new heterotopic bone lesions and is generally well tolerated in adults with fibrodysplasia ossificans progressiva (FOP), an ultra-rare and disabling genetic disorder.

Oct 24, 2026
news

Oral Health for Adolescents: Key Recommendations from the 2026 AAP Clinical Report

A concise, practice-focused summary of the 2026 AAP clinical report on adolescent oral health—what pediatric clinicians should screen for, prevent, and refer.

Oct 24, 2026
news

Early Lipid Metabolic Alterations in Synovial Fibroblasts: A Window into Rheumatoid Arthritis Pathogenesis

Enhanced lipolysis in synovial fibroblasts marks early pathogenic changes in individuals at risk for rheumatoid arthritis, indicating metabolic shifts precede clinical disease onset.

Oct 24, 2026
Gastroenterology

Bridging the Gap: Global Disparities in Liver Transplantation and Disease Burden (2000-2023)

This article analyzes global liver transplantation disparities relative to cirrhosis and chronic liver disease burden, revealing unequal access dominated by high-income countries and highlighting the role of health system development in tra

Oct 24, 2026
Allergy & Immunology

Litifilimab Shows Promising Efficacy and Safety in Treating Cutaneous Lupus Erythematosus: Insights from the AMETHYST Phase 2 Trial

The AMETHYST Phase 2 trial demonstrated that litifilimab significantly improves skin symptoms in cutaneous lupus erythematosus with a favorable safety profile, marking a potential new targeted treatment for this challenging condition.

Oct 24, 2026
General Surgery

Ultrasound as a Reliable Tool for Localizing Lymphovenous Anastomosis Sites in Lymphedema Surgery: Diagnostic Accuracy and Clinical Implications

Ultrasound demonstrates high accuracy and reproducibility in preoperative localization of lymphovenous anastomosis sites, outperforming existing methods and offering a robust tool for lymphedema surgery planning.

Oct 24, 2026
Critical Care

Heightened Risk of ICU-Acquired Infections in Hematological and Immunosuppressed Cancer Patients: Insights from a Large Brazilian Cohort

A large nationwide cohort study reveals that patients with hematological malignancies and other immunosuppressive conditions have significantly higher risks of ICU-acquired infections, while those with solid tumors do not show increased inc

Oct 24, 2026
Internal Medicine

Unraveling Racial Disparities in Respiratory Tract Infection Diagnoses and Antibiotic Prescribing Patterns

Racial disparities in respiratory tract infection diagnoses partially explain lower antibiotic prescribing rates in non-White patients, highlighting the need for equitable clinical assessment and antibiotic stewardship.

Oct 24, 2026
Hematology-Oncology

Targeting Immunoglobulin Constant Domains: A Novel T-Cell Receptor-Based Immunotherapy for Multiple Myeloma

This study identifies immunoglobulin heavy chain constant domain-derived peptides as promising TCR therapy targets in multiple myeloma, demonstrating selective cytotoxicity and potential to preserve humoral immunity.

Oct 24, 2026
news

Immunomodulatory Effects of Clarithromycin in Community-Acquired Pneumonia: Insights from the ACCESS Trial’s Inflammatory Proteome Analysis

This study reveals that clarithromycin modulates inflammatory cytokines in community-acquired pneumonia, identifying distinct immune endotypes that may guide personalized immunomodulatory therapy.

Oct 24, 2026
news

Charlson Comorbidity Index as a Predictor of Visual Outcomes in Retinal Vein Occlusion-Related Macular Edema: Insights from a Decade-Long Cohort Study

Higher Charlson Comorbidity Index scores correlate with worse 1-year visual acuity outcomes in macular edema secondary to retinal vein occlusion, highlighting the impact of systemic health on ocular prognosis.

Oct 24, 2026
news

Understanding Patient-Initiated Communication in Septorhinoplasty: Prevalence, Themes, and Predictors

This article analyzes perioperative patient-initiated communication in septorhinoplasty, highlighting common concerns and identifying factors linked to increased contact with clinical teams, providing insights to improve patient care qualit

Oct 24, 2026
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    Optimizing Postoperative Opioid Prescriptions After Intra-Abdominal Cancer Surgery: Comparing the 5x-Multiplier and 3-Tier Models

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