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The clinical briefing

Medical news

8,171 articles

Latest updates

Clinical Updates

Quadriceps Strength Recovery Trajectories Following ACL Reconstruction: Associations with Preoperative Predictors but Not Clinical Outcomes

Quadriceps strength recovery after ACL reconstruction exhibits three distinct trajectories linked to preoperative strength and meniscectomy status, yet these trajectories do not correlate with postoperative clinical outcomes at one year.

Oct 26, 2026
Neurology

Enhancing Post-Stroke Physical Activity Through Telehealth and Wearable Technology: A Feasibility Randomised Controlled Trial

A feasibility RCT demonstrates that a telehealth-delivered behaviour change intervention, augmented with a physical activity monitor, can increase physical activity in post-stroke individuals, supporting future large-scale trials.

Oct 25, 2026
Dentistry

Advancing Dental Education: Repair Versus Replacement of Defective Composite Restorations in Canadian Dental Schools

A comprehensive assessment of the teaching practices regarding repair and replacement of defective composite restorations in Canadian dental schools highlights the move towards minimally invasive dentistry and calls for harmonization of edu

Oct 25, 2026
Clinical Updates

Immunogenicity and Safety of Fractional 17DD Yellow Fever Vaccine Doses in Young Children: Evidence from a Phase 4 Randomised Trial in Uganda and Broader Context

Fractional doses (one-fifth and one-half) of 17DD yellow fever vaccine demonstrate non-inferior immunogenicity and comparable safety to full doses in children aged 9–23 months, supporting dose-sparing strategies during vaccine shortages.

Oct 25, 2026
Emergency Medicine

Enhancing Prehospital Pediatric Ventilation Quality with Real-Time Feedback Devices: Insights from a Randomized Study

A randomized crossover study reveals that manual ventilation quality in pediatric respiratory arrest is suboptimal among EMS clinicians, but use of a ventilation feedback device significantly improves adherence to pediatric ventilation guid

Oct 25, 2026
news

Nerandomilast Shows Promise in Slowing Progressive Pulmonary Fibrosis in Autoimmune Disease: Insights from the FIBRONEER-ILD Trial

The FIBRONEER-ILD trial demonstrates nerandomilast’s potential to slow lung function decline and reduce mortality in patients with autoimmune-related progressive pulmonary fibrosis, with a favorable safety profile.

Oct 25, 2026
news

Long-Term Proton Pump Inhibitor Use Post-Lung Transplantation: Near-Universal but No Clear Benefit on Clinical Outcomes Over Two Decades

A 20-year observational study reveals near-universal long-term proton pump inhibitor use in lung transplant recipients without demonstrable improvements in graft function or survival, challenging routine PPI prescriptions in this population

Oct 25, 2026
Allergy & Immunology

Ivarmacitinib Shows Promising Rapid Efficacy and Immune Modulation in Palmoplantar Pustulosis: Insights from a Multicenter Clinical Trial

Ivarmacitinib, a selective JAK1 inhibitor, demonstrated rapid efficacy and immune remodeling in palmoplantar pustulosis over 12 weeks, with favorable safety and potential biomarkers for response stratification.

Oct 25, 2026
Anesthesiology

Outpatient Lipoabdominoplasty Using Sedation, TAP Block, and Tumescent Anesthesia: A Safe and Effective Pain Management Strategy

This study demonstrates that lipoabdominoplasty performed under sedation with TAP block and tumescent anesthesia is safe, effective, and feasible in an outpatient setting, offering excellent pain control, minimal nausea, and high patient sa

Oct 25, 2026
Clinical Updates

Association of Tele-Critical Care Capability With Interhospital Transfers and Potentially Low-Value Transfers Among Critically Ill Medicare Beneficiaries: A Nationwide Evidence Synthesis

This review synthesizes evidence linking tele-critical care with interhospital transfer patterns and outcomes, highlighting improved transfer selection and reduced low-value transfers among critically ill Medicare patients.

Oct 25, 2026
Superintelligence

Enhancing Ambulatory Care: Patient Experiences with Ambient AI Scribes

This qualitative study explores how ambient AI scribes affect ambulatory patient experience, revealing improvements in communication, visit thoroughness, and patient comfort influenced by demographic and relational factors.

Oct 25, 2026
Clinical Updates

Combining Midostaurin with Low-Dose Cytarabine and Venetoclax in Older Adults with Newly Diagnosed AML: Evidence and Implications from the INTERVENE Phase 2 Trial

The INTERVENE trial reveals that adding midostaurin to low-dose cytarabine and venetoclax is tolerable and improves FLT3-ITD clearance and survival in older AML patients with FLT3-ITD, addressing resistance in this high-risk subgroup.

Oct 25, 2026
news

Fertility, Pregnancy, and Women’s Health in Bronchiectasis: Insights from a Multicenter Study and Global Patient Survey

Women with bronchiectasis face unique reproductive challenges, particularly those with primary ciliary dyskinesia (PCD). Pregnancy often involves exacerbations, but neonatal outcomes remain generally favorable with proper pulmonary care.

Oct 25, 2026
news

Optimizing Intraocular Lens Power Calculations in Extremely Long Eyes: The Role of Axial Length Adjustment and AL/R Ratio

This study highlights the superiority of the Holladay 1 formula combined with Wang-Koch axial length adjustment in predicting refractive outcomes in eyes with axial length ≥30 mm, introducing the AL-to-corneal radius ratio as a novel strati

Oct 25, 2026
Neurology

Neurotologic and 3D-FLAIR MRI Correlates in Idiopathic Acute Unilateral Audiovestibulopathy: Advancing Diagnosis and Understanding

MRI positivity in 52% of idiopathic acute unilateral audiovestibulopathy patients correlates significantly with vestibular deficits, particularly in the posterior canal, aiding diagnostic clarity and revealing pathophysiological insights.

Oct 25, 2026
General Surgery

Mesh Position Matters: Patient-Reported Outcomes After Elective Incisional Hernia Repair in a Danish Nationwide Cohort

A large Danish study evaluates how mesh placement during incisional hernia repair affects patient-reported outcomes, finding increased foreign body sensation with onlay mesh but no differences in chronic pain or recurrence.

Oct 25, 2026
news

Prenatal Maternal Phosphatidylcholine and Children’s Behavior and Cognition through 4 Years of Age: Randomized Clinical Trial

A randomized clinical trial shows prenatal phosphatidylcholine supplements support fetal brain development, reducing early childhood social withdrawal and improving cognitive performance without significant safety concerns.

Oct 25, 2026
Internal Medicine

Vascular Risk Factors as Key Contributors to Late-Onset Epilepsy: Insights from a Large US Cohort Meta-Analysis

A comprehensive meta-analysis of six US cohorts identifies vascular risk factors including smoking, hypertension, diabetes, chronic kidney disease, stroke history, and APOE ε4 genotype as significant predictors of late-onset epilepsy in old

Oct 25, 2026
Diabetes & Endocrinology

Setmelanotide Therapy Reduces Metabolic Syndrome Risk in Patients with POMC or LEPR Deficiencies

Setmelanotide, an MC4R agonist, improves metabolic parameters and reduces metabolic syndrome severity in patients with POMC or LEPR deficiencies causing severe obesity, after one year of treatment.

Oct 25, 2026
Cardiology

Unraveling sST2’s Role in Fulminant Myocarditis: A Novel Mitochondrial Therapeutic Axis

Elevated soluble ST2 worsens fulminant myocarditis by impairing cardiomyocyte mitochondria via IGF2R-YY1, providing a new prognostic biomarker and therapeutic target.

Oct 25, 2026
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    Precision Medicine for Long QT Syndrome Type 2: Lumacaftor Corrects Trafficking Defects and Shortens QT Interval

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    Optimizing Postoperative Opioid Prescriptions After Intra-Abdominal Cancer Surgery: Comparing the 5x-Multiplier and 3-Tier Models

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