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The clinical briefing

Medical news

8,171 articles

Latest updates

General Surgery

Tailoring Prognostication in Pancreatic Ductal Adenocarcinoma: Impact of Neoadjuvant Therapy on Survival Predictors

Neoadjuvant therapy alters key prognostic factors in resected pancreatic ductal adenocarcinoma, enabling personalized survival prediction models distinct from chemo-naïve patients.

Oct 27, 2026
Infectious Diseases

Evaluating Cytology and High-Risk HPV Testing in HPV-Vaccinated Young Women: Insights from a Scottish Prospective Study

This prospective Scottish study compares cytology and high-risk HPV testing performance in young HPV-vaccinated women, revealing high negative predictive value but lower positive predictive value of hrHPV testing, emphasizing the role of cy

Oct 27, 2026
Neurology

Systemic Fluoroquinolones and Peripheral Neuropathy Risk: Comprehensive Evidence Review and Clinical Implications

A thorough review of systemic fluoroquinolone use reveals minimal association with peripheral neuropathy risk compared to cephalosporins, supported by large cohort studies and pharmacovigilance data, guiding safer antibiotic prescribing.

Oct 27, 2026
Diabetes & Endocrinology

A Recipe for Better Diabetes Management: Embracing the DASH4D Dietary Pattern

The DASH4D diet, a diabetes-adapted version of the DASH eating plan, significantly improves blood pressure and blood sugar control in type 2 diabetes with hypertension, offering a strong evidence-based dietary recommendation for personalize

Oct 27, 2026
Cardiology

Impact of Familial Hypercholesterolaemia on Thymic Ageing: Insights from a Large Chinese Cohort

This study reveals that familial hypercholesterolaemia accelerates thymic ageing, reducing thymic output and altering T-cell diversity; statin therapy partially preserves thymic function, suggesting integrated metabolic-immunologic manageme

Oct 27, 2026
Orthopedics

Enhanced Healing and Zone-Specific Cartilage Protection With Concomitant Meniscal Centralization in Medial Meniscus Posterior Root Repair: Insights From a Rabbit Model

This study demonstrates that combining meniscal centralization with medial meniscus posterior root repair reduces cartilage degeneration and improves healing compared with isolated root repair, revealing zone-specific cartilage preservation

Oct 27, 2026
Neurology

Understanding Loneliness in Traumatic Spinal Cord Injury: Psychosocial Correlates and Clinical Implications

Loneliness in individuals with traumatic spinal cord injury correlates strongly with environmental barriers and depressive symptoms, highlighting the interplay of internal and external factors in mental health outcomes.

Oct 27, 2026
Dentistry

Ten-Year Outcomes of Surgical Intervention for Peri-Implantitis Using Bovine Bone Collagen Matrix, Enamel Matrix Derivative, and Doxycycline

A 10-year prospective cohort study demonstrates high implant survival and clinical stability following surgical peri-implantitis treatment combining DBBMC, enamel matrix derivative, doxycycline, and tailored supportive therapy.

Oct 27, 2026
Oncology

Advancing Treatment in ER-Positive, HER2-Negative Advanced Breast Cancer: Efficacy of Giredestrant Plus Everolimus

A phase 3 trial demonstrates that the oral combination of giredestrant and everolimus significantly improves progression-free survival in patients with ER-positive, HER2-negative advanced breast cancer post-CDK4/6 inhibitor therapy, especia

Oct 27, 2026
Superintelligence

Enhancing Lentigo Maligna Detection with AI-Assisted Dermoscopy: A Clinical Reader Study on Facial Pigmented Lesions

A deep learning model significantly improves lentigo maligna detection and dermatology resident diagnostic accuracy when applied to dermoscopic images of facial pigmented lesions, underscoring AI’s adjunctive role in clinical dermatol

Oct 27, 2026
Clinical Updates

Impact of Substantial Preoperative Weight Loss on Postoperative Outcomes and Healthcare Utilization Following Reduction Mammoplasty in Obese Patients

Recent substantial preoperative weight loss (>10%) in obese patients undergoing reduction mammoplasty is associated with increased surgical site infections and hospital readmissions compared to weight-stable obese patients, highlighting

Oct 27, 2026
Critical Care

Persistent Mental Health Challenges Among Caregivers of ICU Sepsis Survivors: Links to Patient Post-Intensive Care Syndrome

A prospective study reveals that caregivers of ICU sepsis survivors frequently suffer long-lasting mental health issues strongly linked to patients’ mental impairments, underscoring the need for targeted mental health support.

Oct 27, 2026
Neurology

Gaps in Access to Home and Community-Based Services Following Inpatient Rehabilitation for Traumatic Brain Injury in Older Adults

Study reveals disparities in home and outpatient rehabilitation access among older adults after traumatic brain injury, influenced by clinical needs and non-clinical factors such as ethnicity and rural residency.

Oct 27, 2026
Clinical Updates

Venetoclax Plus Azacitidine in Younger Adults with Acute Myeloid Leukemia: Evolving Evidence Beyond Historical Comparisons

Review of recent studies highlights venetoclax plus azacitidine as a feasible and effective therapy in younger AML patients, challenging standard intensive chemotherapy paradigms and suggesting a shift toward lower-intensity regimens with c

Oct 27, 2026
Clinical Updates

Natural History, Treatment, Survival, and Causes of Mortality in Patients With Subsolid and Ground-Glass Nodules: A Comprehensive Clinical Review

This review synthesizes current evidence on subsolid nodules (SSNs) and ground-glass opacities (GGOs), focusing on their natural history, treatment strategies including ablation and surgery, survival outcomes, and mortality causes. It highl

Oct 27, 2026
news

Cost Analysis of Outpatient Ophthalmic Procedures

This study evaluates the financial feasibility and efficiency of common outpatient ophthalmic surgeries at ambulatory surgical centers (ASCs) and hospital outpatient departments (HOPDs) relative to Medicare reimbursement in 2025 and beyond.

Oct 27, 2026
news

Predictors and Outcomes of Delayed Wound Healing Following Modified Sommerlad-Furlow Palatoplasty: Insights from a Large Cohort Study

This study analyzes 1355 cleft palate repairs by modified Sommerlad-Furlow technique, identifying key predictors such as cleft width, surgeon qualification, postoperative infection, and operation duration that influence delayed wound healin

Oct 27, 2026
General Surgery

Revolutionizing Biliary Tract Cancer Staging: Depth-Based Tumor Classification at the Cystic Duct Junction

A novel T classification system based on tumor invasion depth significantly improves prognostic stratification for biliary tract cancers around the cystic duct junction, unifying diverse cancer types under the junctional cholangiocarcinoma

Oct 27, 2026
news

Disparities in Immunotherapy Use for Advanced Endometrial Cancer Among Older Adults: Insights from NCDB Analysis

Immunotherapy use in older patients with advanced endometrial cancer has increased over recent years but remains lower among the oldest and racial minorities, highlighting persisting treatment disparities.

Oct 27, 2026
Hematology-Oncology

DOACs versus Warfarin for Cerebral Venous Thrombosis: Noninferiority Confirmed in Large-Scale Chinese Registry Study

A multicenter Chinese registry study demonstrates that direct oral anticoagulants are noninferior to warfarin in preventing 1-year symptomatic recurrent venous thromboembolism after cerebral venous thrombosis, with exploratory bleeding outc

Oct 26, 2026
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    Precision Medicine for Long QT Syndrome Type 2: Lumacaftor Corrects Trafficking Defects and Shortens QT Interval

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    Optimizing Postoperative Opioid Prescriptions After Intra-Abdominal Cancer Surgery: Comparing the 5x-Multiplier and 3-Tier Models

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