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Medical news

8,171 articles

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Neurology

Antidopaminergic Medications and Clinical Outcomes in Huntington Disease: Insights From the PROOF-HD Placebo-Controlled Trial

This review synthesizes evidence from the PROOF-HD placebo arm and related studies, demonstrating that antidopaminergic medication use in Huntington disease correlates with accelerated decline in functional, motor, and cognitive outcomes, e

Nov 1, 2026
Diabetes & Endocrinology

Lonapegsomatropin Once-Weekly Therapy Shows Comparable Efficacy to Daily Somatropin in Turner Syndrome: 52-Week Outcomes from the New InsiGHTS Trial

This phase 2 trial demonstrates that once-weekly lonapegsomatropin matches daily somatropin in improving height velocity and safety in children with Turner syndrome over 52 weeks, offering a promising alternative to daily injections.

Nov 1, 2026
Cardiology

Early Cholesterol-Lowering Therapy in Familial Hypercholesterolaemia: Insights from the SAFEHEART Study

Initiating cholesterol-lowering therapy during childhood in familial hypercholesterolaemia substantially reduces LDL-C burden and cardiovascular risk, highlighting the importance of early diagnosis and treatment.

Nov 1, 2026
Rehabilitation Medicine

Integrated Digital Therapeutic Combining Exercise and Cognitive-Behavioural Therapy Significantly Reduces Chronic Patellofemoral Pain: A Multicentre RCT

An 8-week smartphone-based digital therapeutic offering personalized exercise and cognitive-behavioural therapy significantly improved pain, knee function, quality of life, and psychological outcomes in patients with chronic patellofemoral

Nov 1, 2026
Neurology

Innovative Point-of-Care Computer Vision for Enhanced Postural Assessment in Brain Injury Rehabilitation

A clinician-led computer vision system enables accurate, feasible, and usable postural assessment in acquired brain injury rehabilitation, demonstrating significant alignment with clinical evaluations and motion capture data.

Nov 1, 2026
Dentistry

CaneStat’s Role in Enhancing Pellicle Properties and Protecting Enamel From Erosion: An In Vivo and Biophysical Analysis

CaneStat, a recombinant hybrid protein, uniquely modulates enamel pellicle properties fostering increased resistance to early enamel erosion, as evidenced by biophysical and clinical assessments.

Nov 1, 2026
Oncology

Sacituzumab Tirumotecan Plus Pembrolizumab in PD-L1-Negative Advanced Non-Squamous NSCLC: A Paradigm Shift in First-Line Therapy

Sacituzumab tirumotecan combined with pembrolizumab significantly improves progression-free survival in PD-L1-negative advanced nonsquamous NSCLC compared to chemotherapy plus pembrolizumab, offering a promising new treatment standard with

Nov 1, 2026
Neurology

Feasibility and Impact of HOPE4ABI: A Digital Intervention Enhancing Mental and Sexual Wellbeing Post-Stroke and Brain Injury

This feasibility RCT demonstrates that the HOPE4ABI digital intervention is acceptable and beneficial for improving mental, sexual wellbeing, and quality of life in stroke and brain injury survivors, warranting a definitive efficacy trial.

Oct 31, 2026
Dentistry

Comparative Cost-Effectiveness of Non-Surgical Periodontal Therapies in General Practice

A cost consequence analysis demonstrated that guided periodontal infection control (GPIC) is less costly than conventional non-surgical therapy (CNST) while achieving similar periodontal health outcomes at six months.

Oct 31, 2026
Oncology

Non-Inferiority of a Simplified 14-Day Trifluridine-Tipiracil plus Bevacizumab Regimen for Refractory Metastatic Colorectal Cancer: Insights from the PRABITAS Trial

The PRABITAS trial demonstrated that a 14-day trifluridine-tipiracil plus bevacizumab regimen is non-inferior to the conventional 28-day schedule in refractory metastatic colorectal cancer, with significantly reduced hematological and gastr

Oct 31, 2026
Infectious Diseases

Immunogenicity and Safety of PHH-1V COVID-19 Vaccine as a Heterologous Booster in Adolescents

PHH-1V, a protein-based COVID-19 vaccine, is shown to be a safe and effective heterologous booster in adolescents, generating strong and lasting immune responses against multiple virus variants.

Oct 31, 2026
Rheumatology

Decoding Immunological Changes Preceding Clinical Synovitis in Imminent Rheumatoid Arthritis

This article explores distinct immune cell activations in ACPA-positive individuals progressing to rheumatoid arthritis, emphasizing type I interferon activity prior to ultrasound-detectable synovitis and subsequent inflammatory shifts mark

Oct 31, 2026
Transplantation

Revolutionizing Organ Preservation: An Ultra-low-cost, Open-source Normothermic Ex Vivo Perfusion Platform

An innovative, ultra-low-cost normothermic machine perfusion (NMP) system was developed and validated, enabling extended organ preservation and in vivo function in porcine and human tissues, offering affordable platforms for research and th

Oct 31, 2026
Dermatology

Risk of Progression from Pediatric Discoid Lupus Erythematosus to Systemic Lupus Erythematosus: Insights from a Multicenter Cohort Study

This study quantifies the risk and identifies predictors for systemic lupus erythematosus development in children presenting with skin-limited discoid lupus erythematosus, highlighting the importance of early monitoring especially in patien

Oct 31, 2026
Ophthalmology

Revolutionizing Upper Eyelid Surgery: Insights from Microscopic Anatomical Studies

This article revisits upper eyelid anatomy through operating microscope observations, revealing detailed structural relationships that enhance surgical precision in upper blepharoplasty, with implications for safer, more effective cosmetic

Oct 31, 2026
Psychiatry

Multimodal Machine Learning-Based Prediction of Relapse in Major Depressive Disorder: Current Evidence and Future Directions

This review synthesizes recent evidence on machine learning models integrating multimodal data for relapse prediction in MDD, highlighting moderate accuracy driven mainly by clinical risk factors and advocating for dynamic approaches to bet

Oct 31, 2026
Critical Care

Machine Learning-Enhanced Radiographic Detection of ARDS Predicts Outcomes in Mechanically Ventilated Patients

A deep learning model identifying ARDS features on chest X-rays independently predicts 28-day mortality and ventilator duration beyond traditional clinical measures in patients undergoing invasive mechanical ventilation.

Oct 31, 2026
Psychiatry

Sustaining Behavioral Insomnia Care in VA PCMHI Clinics: Impact of Implementation Strategy Withdrawal on Treatment Delivery and Medication Use

This study evaluates the sustainment of brief behavioral insomnia treatments in VA primary care mental health clinics after implementation support ended, showing increased therapy delivery and reduced sleep medication prescriptions.

Oct 31, 2026
Hematology-Oncology

Mitigating CD8 T-cell Exhaustion to Overcome CAR T-cell Therapy Failure in Large B-cell Lymphoma

This article reviews how non-alpha IL2 receptor agonist pegenzileukin can counteract CD8 T-cell exhaustion, a key mechanism in CAR T-cell (CART19) therapy failure in relapsed/refractory large B-cell lymphoma, enhancing therapeutic efficacy

Oct 31, 2026
Respiratory

Enhancing Interstitial Lung Disease Diagnosis: The Role of Endobronchial Optical Coherence Tomography in Multidisciplinary Evaluation

This study highlights the diagnostic value of endobronchial optical coherence tomography (EB-OCT) as a complementary, low-risk imaging modality that improves confidence and diagnostic accuracy in interstitial lung disease multidisciplinary

Oct 31, 2026
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  4. 04Cardiology

    Precision Medicine for Long QT Syndrome Type 2: Lumacaftor Corrects Trafficking Defects and Shortens QT Interval

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    Optimizing Postoperative Opioid Prescriptions After Intra-Abdominal Cancer Surgery: Comparing the 5x-Multiplier and 3-Tier Models

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