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The RNF213 p.R4810K variant independently increases risk and severity of extracranial carotid artery disease, distinct from its known association with intracranial atherosclerosis, highlighting new insights into vascular disease genetics an
Advanced MRI analyses identify three biologically distinct subtypes of white matter hyperintensities (WMHs), linking specific lesion evolution patterns with neurodegeneration and vascular/metabolic risks, offering refined insights into cere
This study compares motor-unit reinnervation and functional recovery in severe Parsonage-Turner syndrome and surgically managed traumatic brachial plexopathy, highlighting spontaneous recovery in PTS and benefits of early reconstruction in
This prospective registry reveals a significantly increased risk of stroke or transient ischemic attack within 30 days after pulsed field ablation compared to radiofrequency ablation for atrial fibrillation, highlighting important safety co
A comprehensive multicenter study reveals frequent neuroimaging abnormalities in children with Noonan syndrome and elucidates their associations with genetic variants and neurological symptoms, enhancing understanding of brain involvement i
This study evaluates the eligibility of children with acute ischemic stroke (AIS) for thrombolysis with tPA, revealing only 19% potential eligibility under current guidelines, and highlights opportunities to reconsider treatment in small-ve
Baseline cortical atrophy within an EOAD-specific brain signature predicts progression from mild cognitive impairment to dementia, providing a valuable MRI biomarker for individualized prognosis in early-onset Alzheimer disease.
The ENCHANTED trial post hoc analysis reveals body weight does not alter alteplase dose effectiveness in acute ischemic stroke, but low body weight independently predicts poorer outcomes without increased hemorrhagic risk.
This exploratory longitudinal study reveals that alongside decreased glucose metabolism, elevated brainstem methionine uptake correlates with consciousness improvement in brain-injured patients, highlighting novel metabolic biomarkers for p
The Vibrance-1 phase 2 trial demonstrates that once-daily oral alixorexton significantly improves wakefulness and reduces cataplexy in narcolepsy type 1, with a favorable safety profile supporting phase 3 evaluation.
This study identifies key nongenetic factors impacting disease onset and severity in hereditary ataxias SCA6 and SCA27B, highlighting environmental exposures and demographics as important modifiers beyond genetic mutations.
Cascade genetic screening in hereditary transthyretin amyloidosis (ATTRv) enables earlier diagnosis and intervention, improving survival and highlighting the need for variant-specific surveillance strategies.
This study explores how economic, educational, healthcare, neighborhood, and social factors link to multiple frailty dimensions in Chinese older adults, highlighting cognition as a key intermediary.
This study reveals how respiratory system elastance influences the effects of tidal volume and respiratory rate on outcomes in mechanically ventilated acute brain injury patients, suggesting personalized ventilation strategies based on resp
This study demonstrates that high-resolution 3D facial geometry captured via smartphone accurately and objectively quantifies facial nerve palsy severity, enabling continuous grading, early detection, and improved patient monitoring.
In pediatric myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD), escalation of acute immunotherapy beyond steroids at first attack is linked to significantly fewer relapses within one year and mid-term follow-up, highli
Young survivors of aneurysmal subarachnoid hemorrhage face a lifelong risk of developing new aneurysms, with female sex, smoking, and family history as key risk factors. Smoking cessation reduces this risk, supporting need for lifelong surv
This study elucidates how escalating cognitive workload affects brain activation in novice surgical residents, revealing distinct neural patterns linked to performance resilience or decline during simulated suturing tasks.
This review synthesizes evidence on home-based cognitive training feasibility, adherence, and patient experiences in gynecologic cancer survivors with CRCI, highlighting clinical implications and directions for optimized intervention design
A randomized clinical trial comparing individualized versus standard blood pressure control during mechanical thrombectomy for ischemic stroke showed no significant difference in 90-day functional outcomes or safety.
