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Incidental DWI-positive lesions are prevalent in cerebral amyloid angiopathy and CADASIL, showing disease-specific distributions and associations with neurodegeneration and MRI biomarkers. These findings underscore their potential role as m
Machine learning analysis of brief patient-physician conversations using acoustic speech features can effectively screen for cognitive impairment in primary care settings, enabling scalable early detection.
Secondary analysis of the TEMPO-2 trial reveals that successful recanalization significantly improves 90-day functional outcomes in minor ischemic stroke patients with proven occlusion, with tenecteplase markedly enhancing recanalization ra
This study identifies global and cytotoxic cerebral edema subtypes in cerebral venous thrombosis as key determinants of poor functional outcomes and mortality, providing new avenues for early risk stratification and targeted adjunctive ther
This review synthesizes current evidence on CSF TMEM106B levels in FTLD, highlighting their associations with disease severity, genetic variants, brain atrophy, and clinical progression, emphasizing TMEM106B’s potential as a biomarker
This article explores how physicians determine stroke care goals for patients with disability or dementia, highlighting key challenges, decision factors, and the need for individualized, bias-aware approaches.
Higher parity in cognitively unimpaired postmenopausal women with positive β-amyloid status is linked to accelerated cognitive decline and hippocampal volume reduction, suggesting parity modulates resilience to Alzheimer’s pathology in prec
This review synthesizes evidence on the long-term survival, excess mortality, and health-related quality of life in patients after chronic subdural hematoma surgery, emphasizing sustained mortality risks and cognitive-physical deficits up t
A post hoc BOOST II analysis found that many bedside-labeled intracranial pressure crises were not confirmed by continuous electronic data, challenging current ICP episode definitions in severe traumatic brain injury.
SS-OCTA identified retinal and choriocapillaris microvascular changes associated with cognitive status in Alzheimer disease, including thinner GCC in dementia and a biphasic CCFD pattern, suggesting a promising noninvasive biomarker platfor
The PSRS showed good-to-excellent reliability and moderate-to-strong construct validity in a large RBD cohort, supporting its use as a multidomain measure of prodromal synucleinopathy burden.
The POINTER Imaging study found no overall brain biomarker changes from a structured lifestyle intervention, but participants with lower baseline hippocampal volume showed greater cognitive benefit, suggesting imaging may help identify who
A large US inpatient analysis found similar in-hospital mortality and complication rates after cardiovascular surgery in patients with and without multiple sclerosis, but patients with MS were less often discharged routinely home.
In the EnTRIPS randomized trial, ultra-early remote ischemic postconditioning after successful endovascular thrombectomy was safe but did not significantly improve 90-day functional independence in acute ischemic stroke.
In a large cohort of postmenopausal women, migraine history was associated with a modest increase in ischemic stroke risk over 20 years, while total and hemorrhagic stroke risks were not significantly elevated.
An exploratory ARCADIA analysis suggests that patients with cryptogenic stroke and atrial cardiopathy without severe hypertension-related features may derive greater benefit from apixaban than aspirin, whereas those with high-risk hypertens
In a prospective mild stroke cohort, cranial arterial stenosis was not linked to cSVD, whereas basilar dolichoectasia and wider intracranial arteries were strongly associated with lacunar stroke, higher cSVD burden, incident infarcts, and w
A genome-wide study identified three genetic modifiers of autosomal dominant Alzheimer’s disease, linking them to disease risk, earlier onset, and biomarker changes involving amyloid, tau, TDP-43, and brain aging.
This study found that cryptogenic NORSE causes severe, rapidly rising neuroaxonal injury, measured by NfL, and that higher NfL predicts worse short-term outcome. S100B was not useful for distinguishing groups.
In a 3919-patient individual-level meta-analysis, acute cardiac CT detected cardiac thrombi in 6.2% of ischemic stroke cases, exceeded transthoracic echocardiography yield, added modest imaging burden, and identified patients with worse 90-
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