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Highlight Agitation is prevalent among dementia patients in nursing homes, often managed with pharmacologic agents.…
A nationwide Danish study links prolonged residential road traffic noise exposure with increased Parkinson disease risk, highlighting the protective effect of having a quiet building facade.
This review synthesizes evidence on 2-year psychiatric and neurologic risks post infections across body systems and age groups, highlighting infection-specific risk profiles, age-dependent vulnerability, and mechanistic insights from recent
Combining abdominal electrical stimulation with airway clearance improves cough strength, muscle thickness, and decannulation rates in tracheostomized patients with neurologic disorders, without impacting infection or diaphragm mobility.
A large retrospective study reveals a small but significant increase in CNS demyelination risk among patients treated with TNF-α inhibitors, varying by agent, with generally low absolute incidence.
Brain perivascular space morphometry reveals familial microvascular architecture and neuropsychiatric influences, offering a novel imaging biomarker of cerebral microvascular health beyond traditional vascular risk factors.
A Bayesian network meta-analysis comparing FcRn inhibitors, C5 complement inhibitors, and CD19+ B-cell depletion therapies reveals comparable efficacy but varied safety profiles in generalized myasthenia gravis treatment, highlighting the n
A prospective study identifies impaired hearing and high systolic blood pressure as accessible clinical markers associated with silent cerebral infarcts in women after eclampsia, suggesting potential triage tools for neuroimaging and follow
A novel optically guided stroke model targeting the mediodorsal thalamus in mice revealed disruptions in sleep stability, thalamocortical oscillations, and working memory. Auditory stimulation during sleep restored these functions, undersco
Paired vagus nerve stimulation (VNS) combined with rehabilitation achieves significant and durable improvements in upper extremity function, participation, and quality of life up to two years after chronic ischemic stroke, highlighting its
IL-6 receptor blockade significantly reduces relapse rates in MOG antibody-associated disease, showing comparable efficacy to high-dose IVIG with a favorable safety profile, supporting its role in relapse prevention.
The MAD-MT score integrates clinical and procedural factors to optimize mechanical thrombectomy decisions in distal and medium vessel occlusion strokes, guiding tailored treatment and improving functional outcomes.
Plasma phosphorylated tau biomarkers overlap in Alzheimer’s and prion diseases, risking diagnostic confusion. The NfL/p-tau217 ratio emerges as an accurate plasma biomarker to distinguish prion diseases from Alzheimer’s, improving diagnosti
This study reveals that even amateur soccer heading causes immediate, transient increases in blood biomarkers p-tau217 and S100B, indicating acute neural impact and suggesting a dose-response effect.
This study compares triple nerve transfer alone versus combined with fascia lata suspension, finding that fascia lata suspension significantly improves facial function, symmetry, and psychosocial outcomes in patients with severe soft tissue
This review synthesizes evidence linking ischemic placental disease—comprising preeclampsia, placental abruption, and fetal growth restriction—with increased postpartum maternal risk of neurological and psychiatric hospitalizations within o
This study reveals that female stroke patients are less frequently screened for large vessel occlusion (LVO) yet have a higher LVO prevalence and comparable thrombectomy use to males, with better long-term outcomes post-thrombectomy.
This study elucidates how baseline perfusion imaging parameters impact clinical outcomes and safety in isolated posterior cerebral artery occlusions treated with endovascular therapy, highlighting prognostic significance but limited predict
This study reveals significant income and productivity losses up to 15 years before diagnosis in early-onset dementia, varying across subtypes, underscoring the urgent need for earlier detection and support.
Defecation urgency in IBS is a complex symptom intertwining sensory thresholds and emotional processing, reflected in distinct brain structural changes identified through MRI. Differentiating experimentally induced versus real-life urgency
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