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Analysis of two large cohorts reveals no significant association between levodopa use and freezing of gait in Parkinson’s disease after adjusting for disease severity and duration, emphasizing the primary role of disease progression in this
This study identifies glycine and specific lipid cholesterol proportions as metabolomic markers causally linked to lacunar stroke subtypes, enhancing understanding of cerebral small vessel disease pathogenesis and potential biomarkers.
A study using dual magnetic resonance spectroscopy reveals contrasting thalamic neuronal and bioenergetic profiles in painful versus painless diabetic peripheral neuropathy, highlighting potential biomarkers and mechanisms underlying neurop
A large retrospective study reveals anterior choroidal artery dilation as a key risk for rebleeding in hemorrhagic Moyamoya disease, with indirect revascularization (EDAS) significantly reducing rebleeding and improving outcomes.
This study delineates the clinical and radiographic profile of bibrachial amyotrophy (BBA) complicating spontaneous spinal cerebrospinal fluid (CSF) leaks and highlights the potential benefits of early surgical repair within 10 years of sym
A large European cohort study identifies six circulating metabolites significantly associated with future stroke risk, highlighting their potential in improving early stroke risk prediction beyond classic risk factors.
This study demonstrates that quantifying disconnected white matter fibers via high-resolution disconnectome analysis predicts 90-day outcomes and identifies thrombectomy responders better than conventional measures in acute basilar artery o
Older adults with severe nerve impairment in Bell’s palsy experience markedly poorer recovery, highlighting the critical role of early, aggressive intervention.
Electrodiagnostic tests, notably electroneuronography and electromyography, significantly improve prognosis prediction for Bell palsy recovery, including patients with moderate paralysis (H-B grade IV). These findings support broader use to
This pooled analysis of seven multi-ethnic cohorts demonstrates the combined prognostic value of plasma phosphorylated tau 217 concentrations and APOE-ε4 genotype for predicting risk and timing of cognitive impairment, emphasizing biomarker
A multicenter RCT demonstrates that 10-kHz spinal cord stimulation significantly improves pain relief, sensory function, and nerve fiber density in painful diabetic neuropathy, suggesting potential disease-modifying effects.
This study analyzes global trends comparing ischemic stroke burdens linked to diabetes and atrial fibrillation, revealing a rising impact of diabetes-related stroke and highlighting the need for targeted interventions.
This review explores evidence linking smoking and exhaled carbon monoxide levels to reduced Parkinson’s disease risk, emphasizing a potential protective role of carbon monoxide, supported by recent large-scale cohort data and biologic
This study links MC1R loss-of-function variants to faster motor decline and phenoconversion in Parkinson’s disease, suggesting their value for prognosis and clinical trial design in European descent patients.
Secondary analysis of the TASTE trial reveals tenecteplase confers superior functional outcomes versus alteplase in patients with distal middle cerebral artery occlusions, supporting its use in more peripheral ischemic stroke territories.
This Finnish nationwide study demonstrates that patients with atrial flutter have a substantially lower risk of ischaemic stroke compared to those with atrial fibrillation, highlighting important differences in thromboembolic risk profiles
Diffusion MRI detects microstructural brain changes up to 16 years before white matter hyperintensities appear, offering a valuable early window for cerebral small vessel disease intervention and improved risk stratification.
Accumulating evidence underscores how adverse social determinants of health (SDOH) from early adulthood heighten the risk of early-onset stroke, with dose-dependent effects and disparities by race and sex.
Pregnancy significantly reduces antiseizure medication concentrations, with lamotrigine showing the greatest decline. Polytherapy and body weight modulate these changes, underscoring the importance of individualized therapeutic drug monitor
This retrospective cohort study explores how immigration status influences ICU admission rates and length of stay among ischemic stroke patients in Ontario, revealing longer ICU stays for immigrants despite similar admission rates compared
