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A secondary analysis of the RxPONDER trial finds chemoendocrine therapy causes more lasting cognitive impairment than endocrine therapy alone in both pre- and postmenopausal women.
A PET imaging study reveals increased frontal serotonin release in schizophrenia, particularly in deficit type, tied to worse negative symptoms.
Evidence suggests combined aerobic and strength training post-stroke yields modest improvements in fitness and function but uncertain long-term benefits.
A Cochrane review finds limited and low- to moderate-certainty evidence that behavioural, self-management, or service delivery interventions improve seizure control or quality of life in adults with epilepsy.
Current evidence suggests minimal impact of omega-3 supplementation on neuropathy symptoms or quality of life in adults with diabetes.
Current evidence for behavioural and service delivery interventions in childhood epilepsy is scarce and of low quality, highlighting an urgent need for rigorous, long-term trials.
A large meta-analysis shows colchicine can lower MI and stroke risk without raising serious adverse events, but GI side effects remain a concern.
A 2025 Cochrane review (5 RCTs, 402 patients, mainly women with breast cancer) finds very low- to moderate-certainty evidence that acupuncture delivers small, uncertain sleep diary benefits versus sham or inactive controls and is probably l
The FDA has approved inebilizumab-cdon (Uplizna) for adults with AChR- or MuSK-antibody positive generalized myasthenia gravis based on the phase 3 MINT trial showing a 1.9-point MG‑ADL improvement at 26 weeks versus placebo and sustained b
Systematic review evidence suggests manual therapy with exercise moderately improves function and reduces pain in chronic neck pain compared with no treatment; benefits versus placebo are less clear, highlighting need for further trials and
A large retrospective cohort study shows traumatic spinal cord injury (TSCI) is associated with increased long-term cardiovascular, neurologic, psychiatric, and endocrine morbidity and higher mortality, even in previously healthy adults.
A multicenter cohort study of 555 patients with severe TBI who underwent prehospital rapid sequence induction found postintubation hypotension (SBP <90 mmHg within 10 minutes) in 19.1%, which was associated with higher 30‑day mortality (
Longitudinal tau-PET accumulation follows distinct regional patterns across biological AD stages; aligning trial inclusion and outcome ROIs to baseline tau stage can substantially reduce sample sizes and improve power for disease-modifying
A large prospective study links smell disturbances to at least 139 conditions. Olfactory loss can be an early sign of neurological, ENT, metabolic, or systemic disease — and a practical, underused screening tool clinicians can adopt.
Functional connectivity reliably predicts spatial and temporal tau propagation patterns across atypical Alzheimer’s disease variants, underpinning personalized approaches to diagnosis and therapy.
The MARS multicenter cohort (n=3030) found a lower annual intracranial hemorrhage risk (1.40%/yr) for unruptured brain AVMs than commonly cited. Older age, associated arterial aneurysms, and cerebellar/deep supratentorial location increased
An IPD meta-analysis of six randomized trials (2313 patients) found IV alteplase before EVT modestly increased intracranial hemorrhage—particularly parenchymal hematoma—yet ICH risk must be balanced against IVT-associated improvements in re
A large French registry study shows that how disease-modifying therapies (DMTs) are managed during pregnancy meaningfully affects relapse rates in relapsing‑onset MS; prolonged natalizumab interruption and fingolimod use carry the highest r
Recent multi-site randomized evidence demonstrates that adding intravenous argatroban or eptifibatide to standard thrombolysis within 3 hours of stroke onset does not improve functional recovery and is associated with increased mortality, i
This review synthesizes recent large-scale multi-cohort studies revealing white matter microstructural abnormalities—especially free water increases—in limbic tracts as critical markers of cognitive decline in aging and Alzheimer’s di
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