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TAPIS subgroup analysis reveals that ticagrelor-aspirin combined with thrombolysis may improve outcomes in moderate ischemic stroke patients with multiple acute infarcts, without increasing hemorrhage risk, suggesting infarct pattern as a p
Cilostazol promotes dural lymphatic remodeling and hematoma clearance post-ICH without increasing bleeding risk, representing a promising therapeutic strategy to improve neurological outcomes.
This study demonstrates that cerebrospinal fluid beta-amyloid peptides correlate with MRI markers of disease severity in probable cerebral amyloid angiopathy, suggesting CSF biomarkers provide a direct measure of vascular amyloid burden, in
This study reveals that central autonomic network alterations in temporal lobe epilepsy patients contribute to interictal cardiorespiratory dysfunction, potentially increasing SUDEP risk, and highlights connectivity changes post-surgery imp
A retrospective study found that postoperative prednisone tapering does not reduce delayed facial nerve palsy incidence following acoustic neuroma resection and carries a 10% risk of steroid-related side effects.
This study evaluates differential item functioning in the EQ-5D-5L questionnaire among acute ischemic stroke patients, revealing minimal impact of age-related biases on quality of life measurement across sex and treatment groups.
This article details how BCKDK, a hypoxia-induced kinase, disrupts branched-chain amino acid metabolism to worsen neuronal injury in cerebral ischemia, highlighting its potential as a novel therapeutic target.
Elevated plasma p-tau217 correlates with cognitive impairment and altered sleep microarchitecture in older adults with late-onset unexplained epilepsy, highlighting potential pathways linking neurodegeneration, epilepsy severity, and sleep
Longitudinal analysis of blood proteins reveals distinctive trajectories and associations with cognitive decline in adults with Down syndrome, shedding light on Alzheimer’s disease pathophysiology in this high-risk group.
The STRATEGY trial assessed whether combining tirofiban with aspirin improves outcomes in branch atheromatous disease (BAD)-related stroke but found no significant benefit over aspirin alone in preventing neurological deterioration or recur
This review synthesizes recent evidence demonstrating guanabenz’s manageable safety profile and efficacy in delaying ambulatory decline in early-onset vanishing white matter disease, highlighting translational pharmacokinetic data and
A comprehensive cohort study from the EURAP registry reveals that antiseizure medication, especially polytherapy and certain monotherapies, increases the risk of poor fetal growth, underscoring the need for optimized treatment strategies du
A novel noninvasive imaging technique using [18F]GP1 PET/CT enables direct identification of thrombi in acute ischemic stroke, improving etiologic classification and predicting recurrence risk, heralding mechanism-based stroke management.
This large prospective cohort study found no significant association between prenatal organophosphate pesticide exposure and autism-related traits in children, after comprehensive adjustments including maternal diet and sociodemographic fac
Cherry angiomas are significantly more prevalent and occur at younger ages in individuals with Neurofibromatosis Type 1 (NF1), linked to biallelic NF1 inactivation in vascular cells. This discovery expands the vascular phenotype of NF1 and
Liver transplantation facilitates early neurocognitive recovery in end-stage liver disease patients by restoring cortical network activities, with S-methyl-5′-thioadenosine playing a pivotal neuroprotective role through modulating neu
This case series examines eight patients experiencing dysphonia after vagus nerve stimulator placement, highlighting variable and transient vocal fold motion changes during device cycling.
This multicenter study reveals that recent mechanical venous thrombosis risk factors markedly increase the risk of cryptogenic ischemic stroke in young adults, especially in those under 40 and with patent foramen ovale, independent of throm
The elderly mobility scale calculator (EMS calculator) is a validated clinical assessment tool designed specifically to evaluate functional mobility i
This multicenter study reveals that recent mechanical venous thrombosis risk factors within 14 days significantly increase the risk of cryptogenic ischemic stroke in young adults, notably in those under 40 and with patent foramen ovale, ind
