Lifelong Risk of De Novo Aneurysm Formation in Young Survivors of Aneurysmal Subarachnoid Hemorrhage: A Four-Decade Perspective

Young survivors of aneurysmal subarachnoid hemorrhage (aSAH) have a persistent, lifelong risk of developing de novo intracranial aneurysms, with cumulative incidence reaching 30% over 40 years.
Female sex, active smoking, and positive family history significantly increase the risk of de novo aneurysm formation; smoking cessation notably lowers this risk in a dose-dependent manner.
No aneurysm ruptures occurred in patients under systematic radiological surveillance, highlighting the effectiveness of long-term monitoring.
One-third of aneurysm ruptures occurred more than 20 years after the initial hemorrhagic event, underscoring the need for lifelong vigilance in this population.

This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

Young survivors of aneurysmal subarachnoid hemorrhage (aSAH) have a persistent, lifelong risk of developing de novo intracranial aneurysms, with cumulative incidence reaching 30% over 40 years.
Female sex, active smoking, and positive family history significantly increase the risk of de novo aneurysm formation; smoking cessation notably lowers this risk in a dose-dependent manner.
No aneurysm ruptures occurred in patients under systematic radiological surveillance, highlighting the effectiveness of long-term monitoring.
One-third of aneurysm ruptures occurred more than 20 years after the initial hemorrhagic event, underscoring the need for lifelong vigilance in this population.

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