Section
This bibliometric study reveals persistent gender disparities in authorship of critical care publications, with women better represented in low- and middle-income countries and a modest increase in female authorship from 2018 to 2022 global
Admission eosinopenia (≤10 cells/μL) in adults with community-acquired pneumonia is associated with higher ICU admission, mechanical ventilation rates, and longer hospital stays, suggesting its utility as a biomarker for hospital resource p
A randomized clinical trial comparing individualized versus standard blood pressure control during mechanical thrombectomy for ischemic stroke showed no significant difference in 90-day functional outcomes or safety.
This article explores hyperinflammatory and hypoinflammatory phenotypes in severe pneumonia, their clinical impact, and translational mouse models that inform precision therapeutic strategies.
This study evaluates how ICU room characteristics, including room type and visibility, influence mortality and length of stay, finding single rooms increase length of stay without affecting mortality.
Early surgical excision within 48 hours significantly lowers 90-day mortality in adults with severe burns, suggesting it as a beneficial strategy despite increased sepsis risk.
Pre-liver transplantation elevated serum renin levels correlate with increased intraoperative vasopressor use and postoperative acute kidney injury, suggesting its potential as a predictive biomarker for perioperative management and renal r
Early initiation of insulin within two hours for moderate hyperglycemia in ICU patients significantly lowers 30-day mortality compared to delayed or no insulin therapy. This target trial emulation highlights the potential clinical benefit o
A multicenter cohort study shows that in critically ill patients undergoing continuous renal replacement therapy, mortality is more closely associated with fluid balance changes than net ultrafiltration rate, emphasizing patient-specific fl
The SAVE-O2 AI trial demonstrates autonomous oxygen titration significantly improves normoxemia maintenance and reduces hypoxemia duration compared to manual methods in hospitalized acutely ill adults.
Nearly half of psychoactive medications newly prescribed after ICU stays in American adults lack documented diagnostic justification, persisting for up to two years post-hospitalization.
A judgment-based binary triage system demonstrated high sensitivity and low undertriage rates in military trauma, supporting its use despite significant overtriage under combat conditions.
This study emulated a target trial to compare ultra-early (0-3h) versus early (>3-6h) vasopressin initiation after norepinephrine escalation in septic shock, revealing significant mortality and renal therapy benefits with ultra-early use
This study highlights varied outcomes of renal replacement therapy in critically ill patients, identifying subgroups who may benefit despite an overall increase in mortality risk.
A multicenter randomized trial found that initiating a 1-hour resuscitation bundle including early antibiotics, fluids, vasopressors, and hydrocortisone in the prehospital setting did not significantly reduce 28-day mortality in adults with
Severe trauma induces maturation and cytotoxic phenotypes in NK cells but paradoxically decreases expression of activating receptors critical for immune defense, revealing a mechanism underlying posttrauma immune dysregulation and vulnerabi
High-dose rocuronium (>1.2 mg/kg) is associated with improved first-attempt intubation success in ICU patients, though this benefit was not observed in the ED setting. Further randomized trials are needed to confirm these findings.
A multicenter study investigated whether initiating a 1-hour resuscitation bundle—including antibiotics, fluids, vasopressors, and hydrocortisone—in the prehospital setting influences 28-day mortality in septic shock, finding no significant
Secondary analysis of two multicenter trials reveals that high-dose rocuronium (>1.2 mg/kg) improves first-attempt intubation success in ICU patients but not in the emergency department, highlighting a potential dose-dependent effect on
Severe trauma induces phenotypic maturation of natural killer cells but leads to a loss of key activating receptors, potentially driving posttraumatic immune dysfunction and increased infection risk.
