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This review synthesizes evidence on persistent excess mortality after SARS-CoV-2 infection in people with severe mental illness (SMI) during and following COVID-19 vaccination roll-out in England, highlighting disparities in mortality risk
This nationwide Swedish study tracks shifting predictors of critical illness during different COVID-19 pandemic periods and compares them to seasonal influenza, highlighting vaccination status and age as key risk factors for severe outcomes
This study analyzes the epidemiology, treatment processes, and outcomes of critically ill cirrhosis patients undergoing continuous renal replacement therapy, highlighting high mortality rates, anticoagulation practices, and implications of
This study demonstrates that higher airway opening index (AOI), measured by capnography during pediatric CPR, correlates with improved survival and neurological outcomes. AOI is a novel, quantitative marker of airway patency linked to post-
Etiologic investigations after status epilepticus (SE) demonstrate variable diagnostic yield and significantly influence treatment decisions, especially when guided by clinical pretest probability. Tailored diagnostic strategies enhance tim
A large multicenter study shows that balanced crystalloids administered before ICU admission in sepsis patients reduce 30-day mortality compared to saline, supporting early fluid choice’s impact on sepsis outcomes.
A large retrospective study demonstrates that transfusion of low-titer group O whole blood (LTOWB) in trauma resuscitation carries a low and comparable risk of early red blood cell alloimmunization relative to component therapy, including a
This study identifies three distinct phenotypes among patients failing to wean from invasive mechanical ventilation, linking failed initial attempts, withdrawal decisions, and mortality, highlighting the need for tailored management strateg
A randomized controlled trial demonstrates that adjunct low-dose ketamine infusion safely decreases opioid use in mechanically ventilated adults without increasing delirium or adverse events, suggesting potential benefits in ICU analgosedat
This study evaluates driving ability and resumption in adult ICU survivors after critical illness, identifying impairments and demonstrating that targeted interventions enable many to safely resume driving, enhancing post-ICU functional rec
This article discusses the design and evaluation of entrustable professional activities (EPAs) promoting effective teamwork and psychological safety among trainees and advanced practice providers in ICU settings.
This review synthesizes evidence on how hospitals’ prevalence of transfer-in patients relates to risk-adjusted mortality, length of stay, and charges, highlighting complex interplay between patient case mix and hospital performance me
Recent randomized trials show no survival benefit of RhD-positive whole blood over component therapy in trauma, underscoring the need to protect reproductive potential by prioritizing RhD-negative transfusions and follow-up.
Higher hospital cardiac capability correlates with lower mortality in cardiogenic shock patients, and regionalized hub-and-spoke models mitigate the transfer penalty associated with patient instability.
This article reviews over 1100 studies on novel biomarkers for acute kidney injury (AKI) in critically ill patients, highlighting their predictive, diagnostic, and management roles while identifying gaps for future clinical implementation.
Mechanical ventilation during surgery induces neutrophil extracellular vesicles that propagate lung inflammation and contribute to postoperative pulmonary complications, highlighting potential new biomarkers and therapeutic targets.
This multi-institutional qualitative study explores specialty palliative care clinicians’ perspectives on optimizing their role in the ICU, highlighting strategic consultation timing, shared understanding with intensivists, and embedd
This study evaluates ECMO as a standalone respiratory support in ARDS patients avoiding invasive mechanical ventilation, highlighting outcomes, strategy failures, and mortality implications.
This study investigates the association between continuation of non-full code status during surgery and early postoperative mortality, revealing higher mortality risk that aligns with clinical care decisions rather than missed rescue opport
This study evaluates respiratory support and mortality trends in Andes virus-induced hantavirus cardiopulmonary syndrome (HCPS) across Chile, highlighting increased mortality during the COVID-19 pandemic period and a high requirement for in
