Section
High-volume trauma centers independently achieve faster surgical intervention and better outcomes in blunt intestinal injuries, highlighting the critical role of clinical experience and hospital resources in managing these rare injuries.
A national cohort study found that adoption of the Resuscitation Quality Improvement (RQI) program for CPR training did not improve survival to discharge or return of spontaneous circulation in patients experiencing in-hospital cardiac arre
A pragmatic RCT in an Australian ICU found the ABCDEF bundle did not reduce delirium incidence or duration but improved patients’ ability to perform usual activities at 90 days post-discharge, suggesting possible long-term quality of
In hypertensive high-risk patients undergoing major abdominal surgery, targeting an intraoperative mean arterial pressure ≥80 mmHg reduces postoperative organ dysfunction and acute kidney injury compared to the standard target of ≥65 mmHg.
A novel artificial intelligence algorithm enables continuous, noninvasive monitoring of inspiratory muscle effort and patient-ventilator dyssynchrony during mechanical ventilation, demonstrating accuracy comparable to invasive gold standard
The HLH-Risk-Calculator utilizes machine learning to predict initial disease severity and mortality at multiple time points in adult patients with secondary hemophagocytic lymphohistiocytosis, highlighting key biomarkers and advocating for
Unsupervised clustering of echocardiographic and hemodynamic data in sepsis reveals four distinct cardiovascular subphenotypes, each with unique mortality risks and responses to treatment, enabling personalized shock management strategies.
A randomized trial showed no significant differences in 6- and 12-month cognitive, physical, and quality of life outcomes between early restrictive and liberal fluid resuscitation in sepsis-induced hypotension.
A nationwide randomized trial shows decompressive craniectomy does not improve functional outcomes over standard craniotomy but increases delayed intracranial hemorrhage risk in patients with large acute epidural hematoma and tentorial hern
The DigiSep trial assessed the impact of metagenomic next-generation sequencing (mNGS) on sepsis outcomes. While primary endpoint improvement was not significant, secondary analyses revealed benefits in mechanical ventilation duration, shoc
AI-enabled point-of-care EEG monitoring accurately measures seizure burden, showing a dose-dependent association with unfavorable clinical outcomes at discharge, highlighting its potential in critical care.
MARS therapy significantly reduces total plasma piperacillin levels by approximately one-third per session in critically ill liver failure patients, underscoring the need for therapeutic drug monitoring and individualized antibiotic dosing.
This study explores how delays in transferring patients from the emergency department to the ICU influence hospital mortality, revealing diagnosis- and hospital-type-specific associations, particularly in cardiac arrest and trauma cases.
A 4D-CT study reveals early lung mechanics changes after PEEP reduction in ARDS, showing significant alveolar derecruitment and decreased over-inflation with minimal tidal recruitment increase, informing lung-protective ventilation strategi
This retrospective study demonstrates that open bedside surgical tracheostomy (OBST) is as safe as operating room tracheostomy (ORST), with similar complication rates and a significant cost reduction, supporting OBST as the preferred approa
In a multicenter phase 2 trial, early intravenous vitamin C did not improve post-cardiac arrest organ dysfunction and the 10 g dose was associated with worse outcomes, including renal, cardiac, and neurologic signals.
A post hoc BOOST II analysis found that many bedside-labeled intracranial pressure crises were not confirmed by continuous electronic data, challenging current ICP episode definitions in severe traumatic brain injury.
Qualitative interviews show family PTSD after ICU care is shaped by cumulative stressors across the illness trajectory, highlighting the need for continuous, family-centered communication and support.
In PSV patients, passive leg raising–induced PPV change predicted preload responsiveness, especially when inspiratory effort was low by P0.1.
This study found that cryptogenic NORSE causes severe, rapidly rising neuroaxonal injury, measured by NfL, and that higher NfL predicts worse short-term outcome. S100B was not useful for distinguishing groups.
