Evaluating the Impact of a 1-Hour Prehospital Resuscitation Bundle on Septic Shock Outcomes

Highlight

• Implementation of a 1-hour resuscitation bundle in prehospital septic shock management by a mobile ICU (MICU) team was feasible but did not statistically reduce 28-day mortality compared to usual care.
• The bundle included early administration of antibiotics, hemodynamic optimization with fluids and vasopressors, and hydrocortisone when indicated.
• Secondary outcomes, including ICU/hospital mortality, vasopressor-free days, and lengths of stay, showed no significant differences between intervention and control groups.
• Potential confounders included imbalances in center enrollment and marginal differences in treatment intensity between groups.

Study Background