Evaluating the Impact of a Prehospital 1-Hour Resuscitation Bundle on Septic Shock Mortality: Insights from the SAMU Save Sepsis Study

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The SAMU Save Sepsis study investigated whether a structured 1-hour resuscitation bundle—comprising early antibiotic administration, fluid resuscitation, vasopressor support, and hydrocortisone—delivered prehospital by a mobile ICU (MICU) could reduce mortality in septic shock patients. Despite protocol adherence, no statistically significant reduction in 28-day mortality was observed. Secondary endpoints including ICU outcomes and organ support requirements were also similar. Potential factors influencing these findings include imbalances in patient enrollment and marginal intergroup differences in care.

Study Background