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This multicenter observational study demonstrates that ultrasound-guided supraclavicular brachiocephalic vein cannulation is a feasible, safe, and reproducible method for central venous catheter placement in critically ill neonates, with a
The Texas Senate Bill 8 abortion ban is linked to an increased rate of critical illness, sepsis, and infections among hospitalized pregnant women with high-risk features, highlighting significant implications for maternal healthcare in rest
Elevated plasma levels of H3.1 nucleosomes at ICU admission correlate with increased mortality and acute kidney injury requiring renal replacement therapy in sepsis, highlighting their potential as prognostic biomarkers.
This article examines interleukin-6 (IL-6) as a key mediator of therapeutic efficacy in acute lung injury and COVID-19, highlighting its role in modulating inflammation and survival outcomes across multiple clinical interventions.
This study explores whether renal resistive index (RRI) changes during a transient elevation of mean arterial pressure (MAP) can guide individualized MAP targets to optimize renal function in early septic shock, finding that RRI decrease do
This nationwide Dutch study reveals that lower socioeconomic status independently predicts increased ICU hospital mortality regardless of comorbidities, underscoring persistent health disparities in universal healthcare.
Severe burns alter extracellular vesicle protein cargo, revealing coordinated immune and neuronal signaling changes that drive inflammation and healing responses, suggesting novel biomarker and therapeutic avenues.
An expert consensus (STARDaki) extends STARD to improve reporting of diagnostic test accuracy studies for acute kidney injury (AKI), specifying patient selection, reference standards, timing, assay details and test-retest reliability.
A single-center study found that 14% of ICU shifts involve aggression or violence against nurses, with recurrence predicted by longer stay and initial aggressive or verbally violent incidents.
A new organ failure score, A-TANGO, improves ACLF diagnosis and risk stratification compared to standard CLIF-C criteria, validated in large international cohorts.
Persistent tissue hypoperfusion alongside vasopressor dosing improves early risk stratification in refractory septic shock, identifying patients with markedly increased 28-day mortality beyond vasopressor dose alone, as shown in a secondary
Combining abdominal electrical stimulation with airway clearance improves cough strength, muscle thickness, and decannulation rates in tracheostomized patients with neurologic disorders, without impacting infection or diaphragm mobility.
This report highlights the increased risk of health insurance instability in survivors of firearm injury, emphasizing the challenges to continuous care and financial burden post-injury.
This study examines the duration of end-tidal CO2 monitoring needed to distinguish return of spontaneous circulation (ROSC) during out-of-hospital cardiac arrest resuscitation, finding 7 to 21 minutes depending on witness status and initial
This study examines whether high-flow nasal cannula oxygen during breaks from noninvasive ventilation post-extubation reduces extubation failure compared to standard oxygen therapy in high-risk patients.
Early administration of Shenfu injection in septic ICU patients did not reduce vasopressor use but was associated with lower mortality and improved microcirculation, warranting further validation.
Prolonged endotracheal intubation induces progressive tracheal histopathological changes, with increased injury markers beyond 14 days, supporting early tracheotomy to mitigate complications.
The APS Consortium establishes a large, prospective cohort of critically ill adults with ARDS, pneumonia, and sepsis to enable biologically based phenotyping, leveraging rich clinical data and biospecimens for improved understanding and the
A large Indian ICU registry study reveals no significant difference in mortality between sexes despite females receiving less invasive organ support in critical care.
RCT evidence shows that restrictive low-use versus liberal high-use physical restraint strategies in mechanically ventilated ICU patients do not differ in days alive without delirium or coma at 14 days.
