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Long-term cumulative exposure to wildfire smoke PM2.5 significantly increases cardiovascular hospitalizations among U.S. older adults, with notable risks in ischemic heart disease and arrhythmias, highlighting the need for targeted public h
This review synthesizes emerging evidence from the PROACT trials on genotype-first identification of subclinical coronary atherosclerosis using polygenic risk scores (PRS), highlighting feasibility, engagement, and high prevalence of silent
NCACC technology identifies rare cIgG+ epithelial cells at liver cancer invasive fronts, revealing a STAT1-dependent signaling axis promoting aggressiveness and offering new therapeutic targets in liver cancer.
Heterozygous germline mutations in MSH3 and likely MLH3 confer an increased colorectal cancer risk through somatic second hits, inducing hypermutant, microsatellite-stable tumors characterized by signature ID4 and excess somatic deletions.
A large retrospective study reveals anterior choroidal artery dilation as a key risk for rebleeding in hemorrhagic Moyamoya disease, with indirect revascularization (EDAS) significantly reducing rebleeding and improving outcomes.
This study delineates the clinical and radiographic profile of bibrachial amyotrophy (BBA) complicating spontaneous spinal cerebrospinal fluid (CSF) leaks and highlights the potential benefits of early surgical repair within 10 years of sym
A large European cohort study identifies six circulating metabolites significantly associated with future stroke risk, highlighting their potential in improving early stroke risk prediction beyond classic risk factors.
This study demonstrates that quantifying disconnected white matter fibers via high-resolution disconnectome analysis predicts 90-day outcomes and identifies thrombectomy responders better than conventional measures in acute basilar artery o
Older adults with severe nerve impairment in Bell’s palsy experience markedly poorer recovery, highlighting the critical role of early, aggressive intervention.
This article explores genetic heterogeneity in familial thyroid follicular nodular disease, highlighting key gene variants identified via whole-exome sequencing and the implications for diagnosis and management.
This study investigates the association between continuation of non-full code status during surgery and early postoperative mortality, revealing higher mortality risk that aligns with clinical care decisions rather than missed rescue opport
This study reveals that diabetes-related genetic risk scores predict pre-transplant diabetes status and influence metabolic outcomes one year after total pancreatectomy with islet autotransplantation in chronic pancreatitis patients.
A large retrospective cohort study suggests that cetirizine, ibuprofen, and prednisone use in adults with type 2 diabetes is associated with significantly reduced incidence of diabetic macular edema and proliferative diabetic retinopathy, h
This study examines how episiotomy type influences the risk of obstetric anal sphincter injury during operative vaginal deliveries, highlighting mediolateral episiotomy’s protective effect in women without prior vaginal birth and risk
A randomized clinical trial demonstrates that synthetic mesh reinforcement during subcostal abdominal closure notably decreases incisional hernia incidence without increasing postoperative complications, improving patient recovery after hep
This analysis of localized appendiceal adenocarcinoma reveals low relapse rates post-resection, identifies key histopathologic and molecular relapse predictors, and finds no significant benefit from adjuvant chemotherapy, challenging conven
This article reviews expert perspectives on the efficacy and safety of SGLT inhibitors for cardiovascular and renal disease in type 1 diabetes, outlines translational insights from type 2 diabetes data, and proposes a roadmap for regulatory
Assessment of β-cell dysfunction using stimulated glucose and C-peptide measures improves risk stratification for type 1 diabetes progression among single autoantibody-positive relatives, enabling personalized monitoring and targeted interv
This study employs interpretable anomaly-detection algorithms to identify high-risk phenotypes in resected solid pseudopapillary pancreatic tumors, overcoming limitations of conventional survival models in ultra-rare cancer-specific deaths.
In elderly patients with locally advanced esophageal squamous cell carcinoma, neoadjuvant immunochemoradiotherapy offers superior tumor response but increases surgical complexity and cardiac risks compared to immunochemotherapy. Personalize
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