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This study reveals unique fatty acid and oxylipin metabolic signatures that differentiate isolated postcapillary pulmonary hypertension from combined pre- and postcapillary PH, highlighting potential biomarkers and therapeutic targets.
Clonal hematopoiesis of indeterminate potential (CHIP) poses a novel cardiovascular risk. This article explores challenges and strategies for designing cardiovascular outcomes trials tailored to CHIP’s genetic heterogeneity and clinical com
This multicentre study reveals that combining resting left atrial compliance with exercise stress echocardiography significantly improves diagnostic accuracy for HFpEF, potentially reducing the need for invasive testing in patients with une
The PORTHOS study reveals a 16.5% prevalence of heart failure among Portuguese adults aged 50+, with HFpEF constituting over 90% of cases, mostly undiagnosed, highlighting the need for enhanced screening strategies in aging populations.
A novel left atrial (LA) staging system, integrating hemodynamic load and contractile function, predicts new-onset atrial fibrillation risk in hypertrophic cardiomyopathy and may guide tailored AF surveillance.
Lactylation of HNRNPK at K405 links metabolic stress to inflammatory RNA splicing, promoting pathological Jag2 isoform expression and exacerbating myocardial ischemia/reperfusion injury, revealing novel therapeutic targets.
Five-year data from KEYNOTE-826 confirm pembrolizumab combined with chemotherapy as a durable, first-line treatment improving survival in persistent, recurrent, or metastatic cervical cancer without new safety concerns.
An international, evidence-driven consensus harmonizes diagnostic and treatment approaches for soft tissue and visceral leiomyosarcoma, emphasizing multidisciplinary care, site-specific strategies, and priorities for research.
This study evaluates respiratory support and mortality trends in Andes virus-induced hantavirus cardiopulmonary syndrome (HCPS) across Chile, highlighting increased mortality during the COVID-19 pandemic period and a high requirement for in
Rapid immunoassay-based classifiers accurately identify hyper- and hypoinflammatory subphenotypes in critically ill children, preserving prognostic and predictive utility and enabling precision therapies in acute pediatric cardiorespiratory
Pediatric mental health ED visits in the US have surged 2016-2022, exhibiting volume-dependent disparities in patient demographics and diagnoses, highlighting opportunities for tailored interventions to enhance care across diverse emergency
This study evaluates the data quality, variability, and clinical outcomes of inpatient social determinants of health screening across 18 hospitals, revealing important disparities and validating the screening tool’s clinical relevance
Initiation of menopausal hormone therapy during perimenopause or early postmenopause in women with vasomotor symptoms is associated with a reduced cardiovascular risk, especially among Black women and those starting therapy within 10 years
A UK prospective cohort study reveals a U-shaped association between hemoglobin concentration and mortality, with both low and high levels linked to increased death risk across age and sex groups.
Bridging therapy before BCMA-directed CAR T-cell infusion in relapsed/refractory multiple myeloma impacts disease control and outcomes. This study analyzes regimen efficacy and safety in 399 patients, highlighting variable responses and saf
Analysis of SEER data from 2000-2021 reveals incidence, survival trends, and demographic disparities in US patients with myeloproliferative neoplasms, highlighting improved outcomes particularly in primary myelofibrosis and areas for furthe
PRMT9-mediated arginine methylation drives venetoclax resistance in AML by altering RNA splicing and protein synthesis. Targeting PRMT9 restores venetoclax sensitivity, offering a promising approach to combat resistant AML.
Astegolimab, an anti-ST2 monoclonal antibody, significantly reduced moderate/severe exacerbations in COPD patients with frequent exacerbations in pooled ALIENTO and ARNASA analyses, showing promise for targeting the IL-33/ST2 pathway with g
This study reveals significant shifts in the bacterial spectrum, antimicrobial resistance, and clinical presentation of acute postcataract endophthalmitis over 23 years, underscoring the need for updated surveillance and tailored treatment
This study identifies unilateral hearing loss, older age, and insurance status as key factors associated with poor adherence to bone conduction hearing devices in children with microtia, emphasizing the critical role of routine monitoring o
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