Section
A phase 1b/2 study evaluating zilovertamab combined with ibrutinib in relapsed/refractory CLL reveals safety, mechanistic inhibition of ROR1 signaling pathways, and a potential efficacy signal in del(17p) patients warranting further studies
A phase 2 randomized trial shows that TISA-818, an anti-inflammatory montelukast-decapeptide conjugate, is safe and may improve respiratory outcomes in ARDS patients, especially non-intubated individuals, supporting larger trials.
This multicenter RCT demonstrates that contrast-enhanced ultrasound (CEUS)-guided biopsy surpasses conventional US- and CT-guided modalities in diagnostic yield, sensitivity, and safety for subpleural lung lesions, highlighting its clinical
Sputum eosinophilia is linked to increased asthma-specific health services use, while neutrophilic inflammation drives hospitalizations in COPD. Understanding these inflammatory patterns aids personalized management and resource planning.
A polygenic risk score (PRS) significantly associates with IPF diagnosis and mortality, demonstrating potential for improving clinical risk stratification using real-world biobank data.
A randomized trial shows that a 6-week corticosteroid taper is superior to a 3-week taper for mild immune-related pneumonitis, establishing 6 weeks as the evidence-based standard for short-term treatment success.
This study reveals mycophenolate and azathioprine do not improve 3-year transplant-free survival or lung function in fibrotic ILD, with potential harm in select subtypes. Robust randomized trials remain essential for guiding immunosuppressi
This retrospective cohort study indicates that menopausal hormone therapy (MHT) is associated with increased risks of strabismus diagnosis and surgery but not reoperation in menopausal women, revealing significant ocular alignment considera
This study elucidates the dynamic nature and structural correlates of mid-phase hyperfluorescent plaques on ICGA in CSCR, highlighting their progression stages and OCT features that signal disease activity.
Ocular proton therapy causes significant decreases in corneal nerve fiber parameters in uveal melanoma patients, with partial recovery by 12 months and minimal changes in corneal sensitivity and patient-reported outcomes.
This study introduces a four-tier descriptive framework for petroclival and temporal bone meningiomas that shows significant correlation with surgical outcomes, offering a valuable tool to guide surgical planning and patient counseling.
This study demonstrates that elevated BMI and obesity classification do not increase the risk of complications or prolong recovery times following open airway reconstruction surgeries, guiding surgical decision-making in overweight and obes
The GLOW phase III trial demonstrates that fixed-duration ibrutinib-venetoclax provides superior overall survival, progression-free survival, and safety compared to chlorambucil-obinutuzumab in older/comorbid CLL patients, with durable dise
This retrospective study assesses the safety and impact of tranexamic acid on bleeding, transfusions, and complications in head and neck free flap surgery, finding no significant difference in outcomes and supporting its safe use.
This study presents a comprehensive single-cell RNA-sequencing atlas of CTCL, identifying oncogenic transcriptional programs and immune microenvironment features that offer new therapeutic targets for advanced-stage disease.
This prospective pilot study demonstrates that gastric point-of-care ultrasound (G-POCUS) performed by trained nurses is a feasible, well-tolerated, and reliable method to assess gastric content in patients recovering from gastrointestinal
This large-scale study reveals that adolescent and young adult women with breast cancer predominantly undergo mastectomy and experience comparable perioperative outcomes to older women, despite a higher metastatic burden.
Early postoperative peripheral parenteral nutrition after colorectal resection reduces inflammatory markers and improves nitrogen balance without increasing complications, suggesting a beneficial supportive strategy in surgical recovery man
An AI-based automatic 3D virtual liver modeling tool accurately predicts intraoperative liver resection complexity (LRC) from preoperative CT scans, outperforming surgeons’ assessments and potentially improving surgical planning and p
A randomized trial found that preoperative analgesic education did not significantly reduce opioid consumption or improve pain scores and satisfaction after surgery, highlighting the need for more intensive interventions.
