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A randomized crossover study reveals that manual ventilation quality in pediatric respiratory arrest is suboptimal among EMS clinicians, but use of a ventilation feedback device significantly improves adherence to pediatric ventilation guid
The FIBRONEER-ILD trial demonstrates nerandomilast’s potential to slow lung function decline and reduce mortality in patients with autoimmune-related progressive pulmonary fibrosis, with a favorable safety profile.
A 20-year observational study reveals near-universal long-term proton pump inhibitor use in lung transplant recipients without demonstrable improvements in graft function or survival, challenging routine PPI prescriptions in this population
Ivarmacitinib, a selective JAK1 inhibitor, demonstrated rapid efficacy and immune remodeling in palmoplantar pustulosis over 12 weeks, with favorable safety and potential biomarkers for response stratification.
This study demonstrates that lipoabdominoplasty performed under sedation with TAP block and tumescent anesthesia is safe, effective, and feasible in an outpatient setting, offering excellent pain control, minimal nausea, and high patient sa
This review synthesizes evidence linking tele-critical care with interhospital transfer patterns and outcomes, highlighting improved transfer selection and reduced low-value transfers among critically ill Medicare patients.
This qualitative study explores how ambient AI scribes affect ambulatory patient experience, revealing improvements in communication, visit thoroughness, and patient comfort influenced by demographic and relational factors.
The INTERVENE trial reveals that adding midostaurin to low-dose cytarabine and venetoclax is tolerable and improves FLT3-ITD clearance and survival in older AML patients with FLT3-ITD, addressing resistance in this high-risk subgroup.
Women with bronchiectasis face unique reproductive challenges, particularly those with primary ciliary dyskinesia (PCD). Pregnancy often involves exacerbations, but neonatal outcomes remain generally favorable with proper pulmonary care.
This study highlights the superiority of the Holladay 1 formula combined with Wang-Koch axial length adjustment in predicting refractive outcomes in eyes with axial length ≥30 mm, introducing the AL-to-corneal radius ratio as a novel strati
MRI positivity in 52% of idiopathic acute unilateral audiovestibulopathy patients correlates significantly with vestibular deficits, particularly in the posterior canal, aiding diagnostic clarity and revealing pathophysiological insights.
A large Danish study evaluates how mesh placement during incisional hernia repair affects patient-reported outcomes, finding increased foreign body sensation with onlay mesh but no differences in chronic pain or recurrence.
A randomized clinical trial shows prenatal phosphatidylcholine supplements support fetal brain development, reducing early childhood social withdrawal and improving cognitive performance without significant safety concerns.
A comprehensive meta-analysis of six US cohorts identifies vascular risk factors including smoking, hypertension, diabetes, chronic kidney disease, stroke history, and APOE ε4 genotype as significant predictors of late-onset epilepsy in old
Setmelanotide, an MC4R agonist, improves metabolic parameters and reduces metabolic syndrome severity in patients with POMC or LEPR deficiencies causing severe obesity, after one year of treatment.
Elevated soluble ST2 worsens fulminant myocarditis by impairing cardiomyocyte mitochondria via IGF2R-YY1, providing a new prognostic biomarker and therapeutic target.
Early postoperative quadriceps strength symmetry strongly predicts patient-reported knee function and satisfaction two years after quadriceps tendon autograft ACL reconstruction, highlighting its role in guiding rehabilitation and assessing
A randomized controlled trial reveals that repetitive transcranial magnetic stimulation combined with vestibular rehabilitation significantly improves dizziness, balance, and postural stability in adults with chronic peripheral vestibular d
This RCT assesses clinical, radiographic, histological, and patient-reported outcomes of soft-tissue augmentation with connective tissue grafts and volume-stable collagen matrices during implant placement in the aesthetic zone.
This randomized trial compared intermittent hemodialysis and continuous renal-replacement therapy in critically ill AKI patients and found that continuous therapy was associated with lower 90-day mortality and similar kidney outcomes.
