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In penetrating liver trauma, angioembolization offers survival outcomes comparable to surgery but is linked to longer hospital and ICU stays, highlighting the need for strategic patient selection and multidisciplinary care integration.
A nationwide Italian survey reveals significant gaps in endocrinologists’ preparedness for transgender care. Prior education strongly improves knowledge and management skills, highlighting urgent needs for structured training to optim
A case series delineating a novel EFEMP1 variant, p.Arg140Trp, associated with late-onset peripheral retinal degeneration distinct from classic DHRD/ML, highlighting rod dysfunction precedes structural changes.
This article examines the critical need for refined clinical metrics in thyroid eye disease (TED) to better evaluate new targeted therapies, highlighting the Innovate TED Initiative’s efforts to develop and validate comprehensive outcome me
Electrodiagnostic tests, notably electroneuronography and electromyography, significantly improve prognosis prediction for Bell palsy recovery, including patients with moderate paralysis (H-B grade IV). These findings support broader use to
Emerging evidence links high pesticide exposure events (HPEEs) in farmers to increased self-reported olfactory dysfunction, though objective smell testing yields inconclusive associations, highlighting critical gaps and methodological consi
An international expert consensus recommends practical principles and minimum requirements for general‑population screening for islet autoantibodies to detect early-stage type 1 diabetes, reduce DKA, enable early care and access to disease‑
The PROTECT trial’s per-protocol analysis confirms teplizumab’s efficacy in preserving beta cell function, reducing insulin needs, and improving glycemic control in children and adolescents newly diagnosed with stage 3 type 1 di
Comprehensive plasma proteomics reveal three molecular subtypes of transthyretin cardiac amyloidosis linked to distinct prognoses and differential tafamidis treatment responses, highlighting personalized therapeutic opportunities.
A multicenter study shows that adults with prolonged unilateral deafness benefit from cochlear implantation, with significant speech perception improvement and sustained device usage, challenging exclusion based solely on deafness duration.
This study evaluates how the number and positivity of lymph nodes affect survival outcomes in over 2,000 patients with stage I–III favorable histology Wilms tumor, underscoring the need for standardized lymph node sampling in surgical stagi
Antibiotic treatment transiently improves pouchitis by suppressing exotoxin-producing bacteria, but resistant strains quickly re-emerge, driving relapse; targeted microbial approaches are needed for sustained remission.
This pooled analysis of seven multi-ethnic cohorts demonstrates the combined prognostic value of plasma phosphorylated tau 217 concentrations and APOE-ε4 genotype for predicting risk and timing of cognitive impairment, emphasizing biomarker
This study reveals that immune checkpoint and VEGF inhibitors, alone or combined, do not induce detectable arterial inflammation by PET, suggesting macrophage-driven plaque activation is not the main cause of related atherothrombotic events
This international cohort study evaluates hypothermic oxygenated perfusion (HOPE) versus normothermic machine perfusion (NMP) in liver transplantation, revealing comparable high graft survival despite differing donor risk profiles and highl
This study investigates clinical and pharmacological factors influencing serum dexamethasone levels during the 1-mg overnight dexamethasone suppression test, revealing age and BMI as key determinants and highlighting the limited impact of r
A multicenter RCT demonstrates that 10-kHz spinal cord stimulation significantly improves pain relief, sensory function, and nerve fiber density in painful diabetic neuropathy, suggesting potential disease-modifying effects.
A nationwide Chinese study reveals that exposure to tropical cyclones increases acute coronary syndrome risk by 14%, delays treatment times, and disproportionately affects vulnerable populations. Coordinated public health and clinical strat
A prospective study reveals that ultra-rare cardiomyopathy gene variants significantly increase risk for early heart failure in infants with hypoplastic left heart syndrome, highlighting potential for genetic risk stratification and precisi
The 2024 update of the Clinical Genome Resource elucidates a rapidly expanding genetic landscape for dilated cardiomyopathy, enhancing clinical genetic interpretation with 35 genes classified as high evidence, including nine novel discoveri
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