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This comprehensive analysis of 8,553 AML patients reveals diverse RAS mutation patterns, their associations with other genomic alterations, and distinct prognostic implications influenced by the genomic context and treatment modalities, gui
A 2026 expert consensus recommends shorter, individualized antibiotic courses for most severe infections in critically ill patients, with clear exceptions and guidance on biomarkers, source control, and stewardship.
This review synthesizes evidence linking routine vaccinations, including COVID-19 and herpes zoster vaccines, with reduced risk of new-onset idiopathic uveitis, highlighting immune mechanisms and clinical impacts.
This study reveals that aggressive electrical stimulation during acute Bell’s palsy recovery may worsen synkinesis and reduce botulinum toxin efficacy, while chronic-phase stimulation improves function, emphasizing a critical cumulati
The Semi-Elective Transplant Initiative (SETI) introduces a systems-based approach to deceased-donor kidney transplantation, improving logistics and graft utilization by shifting to proactive scheduling and expanded machine perfusion, witho
This study uncovers how HSP70-driven inflammatory interactions between macrophages and stromal cells disrupt the endometrial environment, contributing to recurrent implantation failure by impairing decidualization and immune homeostasis.
An expert-practice summary of the 2026 AASLD EXPO on liver biopsy: indications, techniques (percutaneous, transjugular, EUS-guided), sample adequacy, safety thresholds, and emerging applications including molecular profiling and digital pat
This study reveals that midlife plasma p-tau181 predicts faster memory decline over 11 years, highlighting a long prodromal phase of Alzheimer’s disease. Late-life biomarkers p-tau181, NfL, and GFAP correlate with accelerated cognitive decl
This study reveals that elevated 12,13-diHOME levels, reflecting brown adipose tissue activation during targeted temperature management after cardiac arrest, correlate with improved survival and distinct immunometabolic profiles.
Transseptal transcatheter mitral valve replacement with the SAPIEN M3 system in patients with symptomatic mitral annular calcification shows sustained mitral regurgitation reduction, improved functional status, and meaningful quality-of-lif
High-impact physical activity in patients with hip osteoarthritis is associated with a reduced 12-month risk of total hip replacement, without increasing knee replacement risk in knee OA patients. Functional capacity partly mediates this be
This RCT demonstrates that combining multidimensional functional training with inspiratory muscle training and chest physiotherapy improves weaning success, muscle strength, functional independence, pain reduction, and ICU stay following em
This study demonstrates that prior soft-tissue augmentation using autogenous grafts before flapless implant placement significantly enhances peri-implant tissue dimensions compared to simultaneous augmentation or collagen substitutes, under
This phase 3 trial demonstrates that a chemotherapy-free regimen combining ponatinib and blinatumomab significantly improves event-free survival over imatinib plus chemotherapy in adults with Philadelphia chromosome-positive acute lymphobla
A multicenter study demonstrates that interpretable machine learning applied to baseline OCT biomarkers accurately predicts chronicity in central serous chorioretinopathy, facilitating early risk stratification and personalized management.
This study identifies three distinct resting facial synkinesis phenotypes—hypertonic, symmetric, and hypotonic—that can guide targeted static and dynamic surgical treatments to improve patient outcomes.
This secondary analysis of the ANH trial found no significant reduction in allogeneic blood transfusions with acute normovolemic hemodilution in female cardiac surgery patients, but noted increased intraoperative hypotension and longer ICU
This cohort study links postpartum blood pressure at 6 weeks following hypertensive pregnancy disorders with a doubled risk of future cardiovascular disease, highlighting a crucial preventive care window.
Saroglitazar significantly improves liver fat content, liver enzymes, and lipid profiles in women with PCOS and MASLD, highlighting its potential as a therapeutic option in this underrepresented population.
A large-scale UK cohort study found no strong associations between antibodies against multiple common infections and key Alzheimer’s disease neuropathologies, though possible interactions with APOE ε4 genotype and education warrant further
