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This prospective cohort study compares semaglutide, bariatric surgery, and lifestyle therapy in obese patients with MASLD, demonstrating semaglutide and surgery improve liver steatosis and fibrosis markers better than lifestyle changes alon
The DASH4D diet, a tailored DASH-style intervention for diabetes, significantly improved key glycemic biomarkers including fructosamine, fasting glucose, and HbA1c compared to a typical American diet in adults with type 2 diabetes.
Weekly well-day capillary ketone testing maintains predictive accuracy for 1-month diabetic ketoacidosis risk, offering a practical and less burdensome monitoring strategy for patients with type 1 diabetes.
Third-trimester energy restriction in women with gestational diabetes and elevated BMI does not adversely affect infant growth or body composition through the first postnatal year, suggesting safety of modest maternal weight loss in late pr
This article explores ethical dilemmas in pediatric endocrinology through case studies, applying the four-principle framework to guide clinicians in managing complex patient scenarios effectively and compassionately.
A comprehensive multicenter study reveals frequent neuroimaging abnormalities in children with Noonan syndrome and elucidates their associations with genetic variants and neurological symptoms, enhancing understanding of brain involvement i
Adults with type 1 diabetes face substantial financial toxicity and cost-related nonadherence, especially younger adults, underscoring the need for targeted interventions beyond traditional social determinants of health.
A clear, clinician-focused summary of the 2025 VA/DoD guideline update: new screening thresholds, streamlined treatment pathways, integration of pharmacotherapy (including GLP‑1 receptor agonists), endoscopic and surgical options, and veter
This phase 2b trial evaluates bofanglutide’s efficacy and safety compared to semaglutide in Chinese patients with type 2 diabetes, showing notable HbA1c reductions and manageable gastrointestinal side effects.
Elevated plasma pro-opiomelanocortin (POMC) levels accurately predict silent corticotroph adenomas (SCAs) among clinically non-functioning pituitary adenomas, offering a promising tool for diagnosis and monitoring.
This study evaluates teprotumumab’s effectiveness for thyroid eye disease in Japanese patients, revealing notable improvements in orbital inflammation and proptosis compared to intravenous glucocorticoid therapy with distinct MRI-base
The gain-of-function GLP1R R131Q variant slows β-cell decline and improves glycemic response to GLP-1 receptor agonists, highlighting its potential role in precision diabetes therapeutics.
A randomized controlled trial demonstrates that PTeye-guided near-infrared autofluorescence significantly improves identification and preservation of parathyroid glands during total thyroidectomy, reducing transient hypoparathyroidism, espe
This study maps apo AI glycation sites in diabetes, linking them to HDL dysfunction and diabetic atherosclerosis via RAGE-associated signaling, and demonstrates that glycation-resistant apo AI preserves HDL function and lessens atherosclero
Women with preconception hemithyroidectomy face a substantially increased risk of overt hypothyroidism during pregnancy, especially after thyroid cancer surgery, yet obstetric outcomes remain comparable to women with intact thyroids.
A novel protocol performing diagnostic 131I scans within 24 hours after the second rhTSH injection reliably guides radioiodine therapy in differentiated thyroid cancer, enabling same-cycle pre-treatment evaluation and treatment without sche
European experts recommend designated centers, structured diagnostic pathways, and real‑world monitoring to deliver precision therapies (MC4R agonists) safely and equitably to people with rare genetic forms of obesity.
A comprehensive European cohort study reveals that Helicobacter pylori infection’s association with insulin resistance is confounded by socioeconomic and lifestyle factors, arguing against its independent causal role and the need for
A longitudinal study shows no association between fecal short-chain fatty acid levels during pregnancy and early childhood with the progression to islet autoimmunity in children at risk for type 1 diabetes.
A phase 3 trial demonstrated that HTD1801 monotherapy significantly reduces HbA1c and improves cardiometabolic and inflammatory markers in patients with inadequately controlled type 2 diabetes, with sustained effects and a favorable safety
