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Levothyroxine therapy lowering TSH in euthyroid PTMC patients during active surveillance raises reverse T3 levels while maintaining stable free T3, suggesting altered thyroid hormone metabolism and a compensatory adaptive response.
This study reveals that genetic risk factors and immune pathways differ significantly between type 1 diabetes patients stratified by HLA-DR3 and HLA-DR4 status, providing insights into disease heterogeneity and personalized risk mechanisms.
Single-cell RNA sequencing of pancreatic islets reveals distinct molecular signatures linked to specific clinical subtypes of type 2 diabetes, highlighting the heterogeneous pathophysiology and providing potential subtype-specific therapeut
This study demonstrates that initiation of elexacaftor/tezacaftor/ivacaftor (ETI) therapy in children and adolescents with cystic fibrosis improves continuous glucose monitoring (CGM) metrics, correlating with better clinical outcomes.
Presentation of three neuroendocrine tumor cases illustrating theranostics integration in diagnosis, treatment, and management, highlighting receptor-based imaging and personalized radionuclide therapy.
Charcot neuro-osteoarthropathy (CNO) in people with diabetes is linked to frequent emergency hospitalizations, substantial risk of limb amputation, and reduced survival, highlighting urgent need for intensified multidisciplinary care.
A 25-year synthesis of research on gestational diabetes mellitus revealing early metabolic alterations, prevention strategies, optimized treatments, and lifelong consequences for mothers and offspring.
A large Scandinavian study reveals that ketoacidosis risk during SGLT2 inhibitor therapy in type 2 diabetes varies by patient factors and persists beyond early treatment, highlighting the need for ongoing risk assessment and management stra
This article explores how 11-oxygenated androgens differ by PCOS phenotypes and respond to first-line therapies, emphasizing their role in phenotyping and guiding treatment in polycystic ovary syndrome.
This study investigates postoperative complication rates following body-contouring surgery among patients with differing weight-loss methods, revealing that weight-loss modality does not affect complications, while BMI and diabetes at surge
This study examines complication rates following body-contouring surgeries in patients after weight loss via bariatric surgery, GLP-1 receptor agonists, combination therapy, or lifestyle changes, finding modality-independent risk but highli
GLP-1 receptor agonists reduce mortality and cardiovascular events more effectively than SGLT2 inhibitors in serious mental illness (SMI), with early benefits and consistent effects across bipolar disorder, major depression, and schizophren
Less than half of diabetes patients discharged from the emergency department receive timely outpatient follow-up, underscoring critical care continuity gaps that require targeted interventions to improve outcomes.
Increasing neighborhood socioeconomic deprivation is associated with reduced adherence to annual diabetic retinopathy screening among Medicare patients, highlighting disparities in preventive eye care.
A large Dutch cohort study reveals fatigue and cognitive impairment as predominant symptoms in females with prolactinoma, with active disease linked to higher psychological burden despite dopamine agonist treatment.
The Bone Health Index (BHI), derived from metacarpal radiographs, predicts fracture risk more effectively than DXA in children with Osteogenesis Imperfecta, especially infants under five where DXA is limited.
This study evaluates complication rates following body contouring after weight loss via bariatric surgery, GLP-1 receptor agonists, combination therapy, and lifestyle changes, finding weight-loss modality does not affect postoperative compl
PMOS reframes polycystic ovary syndrome as a systemic endocrine-metabolic disorder with lifelong implications, emphasizing the need for comprehensive obstetric and gynecologic care to improve diagnosis, pregnancy outcomes, and long-term hea
Detection of genomic alterations via Afirma Xpression Atlas in indeterminate thyroid nodules enhances malignancy risk stratification beyond Afirma GSC results, guiding surgical decision-making.
This study demonstrates that urinary aldosterone measurement by LC-MS/MS outperforms immunoassay in diagnosing primary aldosteronism, especially when urinary sodium is within an optimal range, offering improved sensitivity and specificity f
