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Cirrhosis entwined with diabetes presents unique clinical challenges. This article offers a pragmatic framework for diagnosis, tailored therapies, and multidisciplinary care to enhance outcomes across liver disease stages.
This study evaluates four commercially available AI systems for diabetic retinopathy screening in Tanzania, demonstrating high sensitivity for referable and proliferative DR and highlighting considerations for implementation in low-resource
End-stage metabolic dysfunction-associated steatohepatitis (MASH) features profound disruptions in thyroid hormone metabolism across liver, portal, and systemic compartments, with the hepatic T3 level and systemic T3/rT3 ratio serving as se
A significant subset of type 1 diabetes patients exhibit low faecal elastase indicative of exocrine pancreatic insufficiency (EPI), associated with longer diabetes duration but not with major changes in diet or symptoms, highlighting the ne
Temple syndrome is an under-recognised imprinting disorder with complex endocrine and growth abnormalities. This large-cohort study clarifies its phenotype, highlights growth hormone therapy benefits, and proposes a novel clinical scoring s
This study highlights that higher baseline and maintained C-peptide levels in type 1 diabetes are linked to reduced risks of acute complications and retinopathy, underscoring the importance of preserving endogenous insulin secretion.
This review synthesizes evidence from the STEP 12 trial and related studies demonstrating that once-weekly semaglutide 2.4 mg significantly reduces bodyweight and improves cardiometabolic outcomes in Chinese adults with overweight or obesit
This Swedish register-based study reveals that GLP-1 receptor agonists are associated with significantly reduced hospitalisations for alcohol and substance use disorders during treatment, with some lasting benefits after discontinuation of
This large multicenter study reveals that nonarteritic anterior ischemic optic neuropathy (NAION) patients exposed to GLP-1 receptor agonists exhibit similar optic disc crowding compared to nonexposed patients, with smaller cup-to-disc rati
Prophylactic thyroidectomy in children with MEN2 mutations shows excellent short-term cancer control but carries notable risk of permanent hypoparathyroidism, especially under age 5, highlighting the need for expert multidisciplinary surgic
A prespecified pooled analysis of three phase 3 trials including 30,787 participants found semaglutide reduced major kidney outcomes versus placebo, with a 16% relative risk reduction in the primary composite and a favourable safety profile across cardio-kidney-metabolic disease.
The ARCHES retrospective cohort study reveals that endometriosis significantly elevates the risk of type 2 diabetes, particularly in specific subtypes and among premenopausal women with lower BMI, highlighting the importance of subtype-spec
This case series describes compassionate use of ersodetug in eight adults with refractory hypoglycemia from malignant insulin-secreting tumors, demonstrating improved glycemic control, reduced hypoglycemia, and enhanced functional status.
Population-based genetic screening and prospective follow-up of at-risk children reduce the severity of type 1 diabetes at diagnosis and enhance one-year treatment outcomes, including lower HbA1c and insulin requirements.
Systemic IL-6 inhibitors are linked to significantly reduced risks of diabetic retinopathy development, progression, and vision-threatening complications, suggesting therapeutic potential for diabetic eye disease.
Elevated maternal third-trimester TRAb levels in Graves’ disease are linked to neonatal thyroid dysfunction and impaired neurodevelopment at 24 months, independent of neonatal thyroid status, highlighting the need for prenatal monitor
Polygenic scores can predict type 1 diabetes risk after gestational diabetes, especially when combined with clinical factors, but show limited utility for type 2 diabetes prediction.
Partial lipodystrophy (PLD) often mimics Cushing’s syndrome (CS), complicating diagnosis. This study reveals overlapping features, limitations of CS clinical scores in PLD, and underscores the need for careful differential diagnosis t
Suspension of prior authorization requirements led to increased access to CGM and insulin pumps and significant HbA1c improvement in type 1 diabetes patients in a safety net clinic, highlighting benefits of reducing administrative barriers.
This study demonstrates that a telehealth-supported community health worker program with structured feedback loops significantly improves diabetes control and care adherence in low-income Hispanic adults.
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