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This real-world study demonstrates a dose-dependent increase in suboptimal thyroid hormone control among adults treated with levothyroxine, emphasizing the need for enhanced TSH monitoring in patients on higher doses.
This review synthesizes evidence linking the 2025 Primary Aldosteronism Severity Classification (PASC) with adrenal venous sampling (AVS) lateralization and treatment outcomes, highlighting its potential to enhance precision in PA managemen
A 12-week randomized trial explored sleep optimization in adults with type 1 diabetes, revealing improved sleep quality and reduced diabetes distress but limited glycemic benefits except in patients with baseline A1C ≥7%.
The TUXEDO-2 trial demonstrated that ultra-thin strut biodegradable polymer sirolimus-eluting stents are noninferior to durable polymer everolimus-eluting stents in diabetic patients with multivessel coronary artery disease at 1-year follow
Iterative redesign of electronic health record (EHR) portal reminders significantly improved mammography screening adherence in an outpatient setting, demonstrating the value of concise messages with scheduling links, while retinal and HbA1
Near-infrared autofluorescence heterogeneity measurement provides a real-time, quantitative tool during parathyroidectomy to distinguish hyperfunctional parathyroid glands from normal tissue, aiding surgical precision and potentially improv
Stimulating TSH receptor antibodies enhance expression of TSHR and IGF-1R in fibroblasts via receptor recycling, elucidating mechanisms underlying thyroid eye disease and identifying potential therapeutic targets.
This study demonstrates that continuous glucose monitoring-derived time in range (TIR) is independently associated with progression of arterial stiffness in type 2 diabetes, highlighting TIR as a valuable metric beyond HbA1c for cardiovascu
Among U.S. veterans with diabetes on dialysis, continuous glucose monitoring (CGM) use was associated with significantly lower mortality risk compared to non-CGM use, highlighting CGM’s potential to improve survival in this high-risk
This study evaluates comprehensive nurse-led telehealth for uncontrolled type 2 diabetes and hypertension in a fee-for-service setting, finding limited improvement in HbA1c but identifying key barriers to implementation.
Erythrocytosis is an underreported hematologic side effect of targeted therapies in advanced thyroid cancers, notably RET inhibitors, occurring early and recurrently without impacting survival outcomes but correlating with disease control r
This study demonstrates that nearly half of islet secretory function is preserved following total pancreatectomy with islet autotransplantation (TPIAT), independent of preoperative glycaemic status or prior pancreatic surgery. Continuous gl
This article explores personalized osteoporosis management, combining evidence-based pharmacologic therapies with individualized lifestyle and nutrition guidance, to improve patient outcomes through shared decision making.
The novel Python-based tool PEPPER enhances electronic medical record searches, efficiently identifying youth with ketosis-prone diabetes, and dramatically reducing manual chart review time without compromising accuracy.
This review synthesizes 20 years of data on pediatric hyperthyroidism, highlighting shifts toward prolonged antithyroid drug therapy, reduced definitive treatments, and rising relapse rates, underscoring the need for individualized long-ter
Liraglutide’s efficacy in type 2 diabetes varies with metabolic state, engaging brain-mediated insulin secretion in healthy individuals, direct islet action in glucose intolerance, and insulin-independent pathways in advanced disease stages
This study evaluates the clinical benefits of semaglutide, a GLP-1 receptor agonist, as an add-on therapy to insulin in patients with LADA, demonstrating improved glycemic control, BMI reduction, and insulin dose sparing, especially in thos
This study identifies six plasma proteins associated with 3-year progression from impaired fasting glucose to diabetes, enhancing risk prediction and offering new mechanistic insights.
Level VII lymph node metastasis in medullary thyroid cancer signifies a highly aggressive phenotype with the poorest prognosis. Reclassifying level VII nodes as N1b improves prognostic accuracy and could refine staging and treatment strateg
This study demonstrates that hyperthyroidism driven by constitutively active TSH receptor mutations alters craniofacial structure and bone mineral density in mice, offering insights into thyroid hormone’s role in skeletal development.
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