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This study reveals that weight gain exceeding 5% in MASLD patients increases liver-related event risks and liver stiffness, whereas weight loss improves liver stiffness and may reduce adverse outcomes, especially with obesity reversal.
Elevated glucocorticoids, androgens, and progesterone metabolites, combined with high BMI and stress, accelerate the onset of puberty in girls, particularly breast development (thelarche).
Incorporating a type 1 diabetes genetic risk score into MODY genetic testing helps identify misdiagnosed T1D cases, particularly in children, optimizing diagnostic accuracy and reducing unnecessary testing.
A multi-centre phase 2 study demonstrates that belatacept combined with sirolimus achieves superior islet transplant outcomes with better renal preservation compared to conventional tacrolimus-based therapy in type 1 diabetes patients.
Switching from daily somatropin to once-weekly somapacitan in adults with growth hormone deficiency maintains lean mass, improves functional outcomes, but may increase adiposity indices, highlighting a trade-off in metabolic effects during
This review synthesizes evidence on daily and weekly patterns of glycemic control in real-world CGM data, highlighting small but consistent temporal variations that inform personalized diabetes care.
This phase 3 trial evaluates the 52-week safety of oral orforglipron in Japanese adults with type 2 diabetes, showing an acceptable safety profile when used alongside diet, exercise, and oral antihyperglycemic drugs.
Early initiation of insulin within two hours for moderate hyperglycemia in ICU patients significantly lowers 30-day mortality compared to delayed or no insulin therapy. This target trial emulation highlights the potential clinical benefit o
This study reveals a significant association between GLP-1 receptor agonist therapy and increased risk of smell and taste disturbances in type 2 diabetes patients, highlighting the need for awareness and monitoring.
This study reveals that copeptin kinetics remain mostly intact in healthy aging, but older adults exhibit diminished copeptin suppression after hydration, potentially explaining their increased vulnerability to hyponatremia.
A 6-month randomized controlled trial found that time-restricted eating (TRE) in adults with type 1 diabetes is safe and improves HbA1c levels but does not significantly reduce body weight compared to calorie restriction or no intervention.
Deep capillary plexus ischemia quantified by geometric perfusion deficit predicts earlier and higher risk of diabetic retinopathy complications than foveal avascular zone enlargement, underscoring GPDd’s clinical utility as a biomarke
This study reveals that distinct gestational diabetes mellitus (GDM) subtypes confer increased risks of prediabetes, diabetes, metabolic syndrome, and cardiovascular disease 10-14 years postpartum, underscoring the need for tailored long-te
This study quantitatively compares the direct healthcare costs of thyroid radiofrequency ablation (RFA) and hemithyroidectomy over one year, revealing cost advantages of RFA driven by reduced facility use, tempered by factors like repeat pr
Experience-based continuous glucose monitoring (CGM) curricula significantly improve internal medicine residents’ confidence in applied patient care skills compared to traditional approaches, supporting hands-on CGM training integrati
Medicare Advantage (MA) shows no significant improvement over original Medicare (OM) in managing type 2 diabetes outcomes or mitigating related social needs despite higher costs, underscoring the need for effective spending strategies.
A large Latin American study shows radiofrequency ablation is a safe, effective minimally invasive alternative for T1a low-risk papillary thyroid cancer, with excellent tumor disappearance rates and minimal complications over 18 months foll
This study reveals that reduced arginine availability during hyperglycaemia distinguishes A-β+ ketosis-prone diabetes from type 2 diabetes, implicating impaired arginine metabolism in ketoacidosis pathogenesis and highlighting citrulline su
Levothyroxine treatment in older adults with subclinical hypothyroidism shows limited impact on cardiometabolic biomarkers overall but may benefit those with higher TSH levels, highlighting nuanced treatment implications and the need for ta
This study reveals that housing instability among adults with uncontrolled diabetes is associated with increased financial strain and cost-related medication nonadherence, underscoring the need for holistic approaches to diabetes care invol
