Section
A phase 1 trial of soquelitinib, a selective ITK inhibitor, showed favorable safety and encouraging efficacy with Th1-skewing immunomodulation in relapsed/refractory peripheral T cell lymphomas, highlighting a novel therapeutic approach.
The TRANSPORT trial showed no superiority of liberal versus restrictive RBC transfusion in septic shock patients with cancer, highlighting no mortality benefit and increased thrombotic events with liberal strategy, underscoring the need for
This study validates the MD Anderson Dysphagia Inventory (MDADI) as a reliable screening tool for VFSS-graded swallowing impairment in head and neck cancer patients and proposes a concise four-item version to optimize clinical utility.
Sentinel lymph node biopsy in atypical endometrial hyperplasia patients identifies occult cancers and refines adjuvant treatment strategies, supporting its safe and feasible use for better risk stratification.
The integrated 40-gene expression profile (i40-GEP) improves risk stratification in high-risk cutaneous squamous cell carcinoma, accurately predicting metastasis and local recurrence, and identifying patients who benefit most from adjuvant
Oncoplastic breast reconstruction (OP) offers comparable safety and aesthetic results to bilateral breast reduction (BBR) while improving quality of life in women undergoing lumpectomy for macromastia.
This review examines emerging evidence on AI-assisted LC-OCT as a noninvasive, accurate tool for detecting subclinical basal cell carcinoma in high-risk patients, highlighting diagnostic performance, subtype classification, and translationa
The MAIA final analysis establishes daratumumab plus lenalidomide/dexamethasone as a superior frontline regimen, significantly extending median overall survival to 7.5 years in transplant-ineligible newly diagnosed multiple myeloma patients
This study demonstrates that detection of circulating tumor DNA (ctDNA) after treatment in large B-cell lymphoma predicts progression-free survival, highlighting the clinical utility of a rapid immunoglobulin rearrangement-targeted assay fo
This study demonstrates that T cells engineered with a dual HLA-restricted TCR against cathepsin G effectively and safely eradicate AML cells, offering a promising immunotherapy for a broad AML patient population.
Combining genetic risk stratification with measurable residual disease enables precise treatment allocation in adult Philadelphia chromosome-negative acute lymphoblastic leukemia, improving survival outcomes and guiding the use of allogenei
Ophthalmic herpes infections generally do not increase overall malignancy risk, but herpes zoster ophthalmicus (HZO) elevates cancer risk in patients with immune dysregulation, underscoring the need for tailored oncologic vigilance.
Physical activity counteracts adiposity-induced immune suppression in lung cancer and non-tumor lungs, restoring antitumor immunity and slowing tumor progression, with implications for lung cancer interception.
This article reviews a study identifying key factors contributing to delays in diagnosing vulvar squamous cell carcinoma, emphasizing provider and system-level influences and the need for timely biopsy and specialist referrals.
A novel protocol performing diagnostic 131I scans within 24 hours after the second rhTSH injection reliably guides radioiodine therapy in differentiated thyroid cancer, enabling same-cycle pre-treatment evaluation and treatment without sche
Neoadjuvant chemoimmunotherapy significantly improves pathologic response rates in resectable head and neck squamous cell carcinoma compared to immunotherapy alone, potentially transforming preoperative treatment strategies.
A multicenter real-world study demonstrates that combining venetoclax with high-dose cytarabine and mitoxantrone significantly improves remission and survival rates in relapsed/refractory AML, with validated risk factors guiding prognostica
A hotspot DHX15R222G mutation collaborates with AML1-ETO fusion to enhance mitochondrial function and leukemia stem cell activity, leading to poorer prognosis and chemotherapy resistance in AML, unveiling OXPHOS inhibition as a promising ta
Neoadjuvant chemoimmunotherapy significantly improves pathologic complete and major responses compared to immunotherapy alone in resectable head and neck squamous cell carcinoma, suggesting a promising avenue to improve treatment outcomes.
This review synthesizes evidence linking neighborhood socioeconomic deprivation with increased Breslow thickness and delayed surgical management in head and neck cutaneous melanoma, highlighting potential mechanisms and clinical implication
