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Solid organ transplant recipients have increased risk of HPV-driven anal dysplasia and cancer due to unique immune alterations from immunosuppression. This article explores the transplant-specific immune dysfunction underlying persistent HP
Solid organ transplant recipients exhibit heightened risk for HPV-associated anal dysplasia and cancer due to unique immunosuppressive alterations. A transplant-tailored model of mucosal immune dysfunction elucidates mechanisms driving pers
A surgeon-led outpatient palliative care clinic for head and neck cancer patients demonstrated significant symptom improvement, prolonged survival, and high rates of home or hospice deaths, underscoring its value in multidisciplinary cancer
This national English study reveals a significant increase in pre-existing cardiovascular disease among patients at cancer diagnosis over two decades, projecting nearly half will have cardiovascular comorbidities by 2050, underlining urgent
A randomized clinical trial demonstrates that routine cardiovascular specialist referral for prostate cancer patients improves cholesterol control but does not reduce major cardiovascular events over nearly 6 years.
Cheminformatic screening identified novel small molecules with apoptotic, autophagic, and reductase-inhibitory activities that selectively kill AML cells, induce mitochondrial dysfunction, and synergize with current therapies, highlighting
Distinct CAR architectures in tisa-cel (4-1BB costimulation) and axi-cel (CD28 costimulation) influence mechanisms of resistance through CD19 loss, affecting relapse rates in B-cell malignancies treated with CD19-CAR-T therapies.
This article explores how health system factors like spending, workforce density, and radiotherapy availability influence lung cancer mortality worldwide, highlighting actionable targets for improving outcomes globally.
This study develops a surgical map delineating high-risk anatomical sites linked to poor local control in salvage endoscopic nasopharyngectomy, improving patient selection and oncologic outcomes in recurrent nasopharyngeal carcinoma.
Over 25% of endometrial cancer patients receiving chemotherapy develop venous thromboembolism, with advanced cancer stage as the key risk factor, highlighting the need for tailored risk assessment and preventive strategies.
This analysis of RTOG 1016 validates the prognostic value of imaging-detected extranodal extension (iENE) in p16-positive oropharyngeal cancer, supporting its integration into the AJCC/UICC TNM9 staging system and its implications for patie
This randomized clinical trial demonstrates that SI-449, a novel cross-linked chondroitin sulfate powder, significantly reduces postoperative adhesions following open rectal cancer surgery, offering a safe and practical adhesion prevention
A propensity-matched study shows adding radiotherapy to neoadjuvant chemotherapy improves pathologic response but does not enhance survival or reduce recurrence in resected pancreatic ductal adenocarcinoma.
CAR T cells targeting the CA19-9 glycan show potent, specific anti-tumor activity in pancreatic and various gastrointestinal cancers, providing new avenues for immunotherapy of hard-to-treat solid tumors.
This study examines the impact of biosimilar introduction on cancer biologics, highlighting reduced costs and market share for originator biologics, benefiting both payers and patients.
Adjuvant chemotherapy shows survival benefits in select subgroups of distal bile duct carcinoma patients post-surgery, emphasizing the need for tailored treatment strategies and further prospective research.
This article explores how oncology clinicians perceive and manage the burden patients face when involved in treatment decisions, highlighting varied clinician approaches to balance patient autonomy with emotional support in shared decision
Comprehensive proteomic and phosphoproteomic profiling of 267 neuroendocrine carcinomas across multiple tissues reveals distinct molecular subtypes, biomarkers, and a novel NAD+ metabolic vulnerability, advancing personalized precision medi
An analysis of 2,556 thymic tumor cases highlights tumor size as a significant predictor of survival outcomes across thymoma, thymic carcinoma, and neuroendocrine thymic tumors.
This study identifies fibroblast-secreted Spondin-2 as a crucial mediator promoting the transition from metaplastic to dysplastic gastric epithelial cells, advancing understanding of early gastric carcinogenesis.
