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Combining circulating methylated SEPT9 with alpha-fetoprotein significantly enhances early hepatocellular carcinoma detection in cirrhotic patients, outperforming AFP alone and allowing improved surveillance sensitivity and specificity.
A genetic study reveals that higher blood manganese levels are significantly associated with increased risks of oral cavity and HPV-positive oropharyngeal squamous cell carcinomas, suggesting a novel biomarker and potential target for preve
This study evaluates the impact of lumpectomy margin widths on local recurrence in postmenopausal women with hormone receptor-positive DCIS undergoing lumpectomy, radiation, and endocrine therapy, suggesting minimal recurrence differences b
This study demonstrates that combining clinical variables with computed tomography radiomics features improves the prediction of recurrence-free survival in high-grade serous ovarian cancer patients undergoing neoadjuvant chemotherapy and s
This study reveals that circulating tumor DNA (ctDNA) status after colorectal liver metastasis surgery predicts survival outcomes and benefits from adjuvant chemotherapy, guiding personalized treatment.
This study reveals significant international differences in concurrent hysterectomy rates during risk-reducing salpingo-oophorectomy among BRCA1/2 variant carriers and explores underlying factors influencing surgical decisions across region
The SUMMIT study reveals that respiratory symptoms are common among lung cancer screening participants and associated with increased lung cancer diagnosis risk within one year, challenging conventional asymptomatic screening definitions.
Laparoscopic HIPEC following upfront treatment in advanced epithelial ovarian cancer is feasible, safe, and preserves patient quality of life, offering a promising consolidation approach.
Two large randomized trials reveal that Helicobacter pylori infection elevates colorectal cancer risk, particularly in individuals with specific bacterial virulence factors or high genetic susceptibility, and that eradication treatment may
Fludarabine, cyclophosphamide, and low-dose TBI combined with post-transplant cyclophosphamide provide a safe and effective single platform for haploidentical and unrelated donor allo-SCT in older AML/MDS patients, showing favorable surviva
This study reveals that hypoxia in centrally located EGFR-mutant lung adenocarcinomas drives an alveolar lineage imbalance via the ZAKα-MAPK-c-Fos pathway, promoting early tumorigenesis. Therapeutic oxygenation can restore lineage balance a
This study identifies dual cutoff values of 0 and 1 mm for radial margin distance in perihilar cholangiocarcinoma, providing a simple and effective stratification tool for postoperative recurrence risk and survival prediction.
The PRO-PLATINUM trial evaluates a novel 5-strain probiotic’s effect on gut and vaginal microbiome composition and clinical outcomes in ovarian cancer patients undergoing platinum chemotherapy, assessing safety, feasibility, and trans
This article reviews evolving therapeutic sequences in advanced hepatocellular carcinoma, highlighting the integration of immune-based combinations, tyrosine kinase inhibitors, liver function preservation, and the emerging multidimensional
Erythrocytosis is an underreported hematologic side effect of targeted therapies in advanced thyroid cancers, notably RET inhibitors, occurring early and recurrently without impacting survival outcomes but correlating with disease control r
The DAPHNe trial demonstrates excellent 5-year outcomes for stage II–III ERBB2-positive breast cancer patients treated with an abbreviated neoadjuvant paclitaxel, trastuzumab, and pertuzumab regimen, with ultrasensitive ctDNA monitoring sho
NEK9 upregulation in hepatocellular carcinoma promotes immune evasion by enhancing PD-L1 expression and recruiting suppressive myeloid cells. Novel NEK9 inhibitors synergize with PD-L1 blockade, remodeling the tumor microenvironment and imp
This international study reveals that many patients with platinum-sensitive recurrent ovarian cancer achieve durable, progression-free survival exceeding 5 years on PARP inhibitors, even after treatment discontinuation, with a low risk of s
Level VII lymph node metastasis in medullary thyroid cancer signifies a highly aggressive phenotype with the poorest prognosis. Reclassifying level VII nodes as N1b improves prognostic accuracy and could refine staging and treatment strateg
This review synthesizes current evidence on lung cancer surgical quality improvement, highlighting the impactful American College of Surgeons Lung NODES Collaborative’s success in improving lymph node sampling compliance and broader a
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