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New Cervical Cancer Screening Guidelines: Patient-Collected HPV Tests Now Recommended
Introduction and Context Despite being highly preventable, cervical cancer remains a significant health threat. The...
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Oncology
Latest updates
Gastroenterology
CD276 Identified as Key Driver of Chemoresistance in Advanced Pancreatic Cancer
Single-cell analysis reveals CD276/B7-H3 as a critical regulator of chemoresistance in pancreatic ductal adenocarcinoma, highlighting its dual role in promoting basal-like tumor states and immune evasion.
Hematology-Oncology
Addressing the Palliative Care Gap in Adolescent and Young Adult Cancer Patients Receiving Medical Assistance in Dying
This cohort study highlights the underutilization of timely palliative care in adolescent and young adult cancer patients opting for MAID, with significant symptom burden and complex psychosocial factors influencing end-of-life decisions.
Hematology-Oncology
Baseline Circulating Tumor DNA as a Prognostic Biomarker in Untreated Follicular Lymphoma: Insights from the GALLIUM Trial
Baseline ctDNA levels predict early progression and poor survival in untreated follicular lymphoma, outperforming traditional risk scores like FLIPI. This study highlights ctDNA’s potential as a stratification tool in clinical trials.
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Immunotherapy Prescribing Patterns and Immune-Related Adverse Events in Head and Neck Cancer
A large claims-based study reveals pembrolizumab dominates immunotherapy prescribing for head and neck cancer, with minimal usage growth since FDA approval. Immune-related adverse events occurred in 41.2% of patients, linked to specific com
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Radiation-Induced OME: Bacterial Colonization Elevates Early Recurrence Risk Yet Lacks Long-Term Prognostic Value
Radiation-induced otitis media with effusion (RI-OME) shows heightened bacterial colonization with opportunistic pathogens. Although microbial presence predicts early recurrence (≤4 weeks post-tympanocentesis), it does not independently inf
news
Community-Centered Education Improves Clinical Trial Knowledge and Self-Efficacy Among Minoritized Women
A culturally tailored educational intervention significantly improved clinical trial knowledge and self-efficacy among African American and Hispanic women, highlighting the potential of community partnerships to address disparities in gynec
news
ACOG Endorses Updated 2026 Cervical Cancer Screening Guidelines: Key Changes and Implications
The American College of Obstetricians and Gynecologists (ACOG) has qualifiedly endorsed the 2026 WPSI cervical cancer screening guidelines. This article details the core recommendations, highlights key updates including self-collection opti
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Advancing Personalized Treatment in Papillary Thyroid Cancer: A Machine-Learning Model for Predicting Occult Lymph Node Metastasis
A novel machine-learning model incorporating clinical, ultrasonographic, and molecular features predicts occult central lymph node metastasis in papillary thyroid cancer, with RET fusion positivity identified as a key risk factor.
General Surgery
Robotic Gastrectomy Outperforms Open and Laparoscopic Surgery in Gastric Cancer Outcomes
A retrospective study reveals robotic gastrectomy achieves higher textbook outcome rates than laparoscopic and open surgery, correlating with improved 1-year survival in gastric cancer patients.
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Selective vs. Universal NGS in Endometrial Cancer: A Cost-Efficiency Breakthrough
A new study reveals that selective molecular profiling with MMR/p53 IHC followed by NGS for p53-abnormal tumors is more cost-efficient than universal NGS for advanced endometrial cancer, reducing unnecessary testing by 57%.
Gastroenterology
A New Framework to Refine Hepatocellular Cancer Surveillance with Risk Stratification Models
The Translational Liver Cancer Consortium proposes a structured framework for developing and validating risk models to optimize HCC surveillance, addressing gaps in current clinical guidelines.
Cardiology
Inflammatory and Cardiac Biomarkers Predict VTE and Bleeding Risks in Cancer Patients
Elevated levels of inflammatory and cardiac biomarkers are linked to higher risks of venous thromboembolism and bleeding in cancer patients, according to a post hoc analysis of the AVERT trial.
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Survival of Patients Diagnosed With Cancer During the COVID-19 Pandemic
A cohort study of over 1 million cancer patients revealed significant reductions in 1-year survival rates during 2020-2021 compared to pre-pandemic trends, with an estimated 17,390 excess cancer deaths attributable to pandemic-related care
Hematology-Oncology
Breaking Ferroptosis Resistance: PRMT5 Inhibition Emerges as a Game-Changer in B-Cell Lymphoma Therapy
PRMT5 inhibition sensitizes B-cell lymphomas to ferroptosis by disrupting the PRMT5-ATF5-SLC7A11 axis, offering a novel therapeutic strategy for relapsed or refractory disease.
General Surgery
Adequate Lymph Node Dissection May Carry a Survival Signal in Intrahepatic Cholangiocarcinoma
An updated meta-analysis suggests lymph node dissection in intrahepatic cholangiocarcinoma may improve survival when it is truly adequate, especially when at least six nodes are retrieved and confounding is reduced.
news
Prophylactic Antibiotics Did Not Significantly Reduce Infection After Vulvar Surgery, Cohort Study Finds
In a prospective cohort of 172 vulvar surgery patients, prophylactic antibiotics were not associated with fewer postoperative infections or complications, supporting the need for a randomized trial.
Diabetes & Endocrinology
Validation of the 2025 ATA Risk Stratification System in a Cohort of Patients with Papillary Thyroid Carcinoma
A real-world study validates the 2025 ATA thyroid cancer risk guidelines, showing significant patient reclassification and identifying a new ‘low-intermediate-risk’ group needing tailored management approaches.
Diabetes & Endocrinology
2025 ATA Risk Stratification for Papillary Thyroid Cancer: Validation Study Reveals Significant Reclassification Shifts
A retrospective study of 670 papillary thyroid carcinoma patients validates the 2025 ATA risk stratification system, demonstrating a shift toward higher-risk classifications. The new ‘low-intermediate-risk’ class emerges as a di
news
Early FDG-PET Predicts Survival Outcomes in Metastatic Breast Cancer: IMPACT-MBC Trial Reveals Rapid Response Imaging as a Powerful Prognostic Tool
The IMPACT-MBC trial demonstrates that performing FDG-PET after just 2 weeks of first-line systemic therapy can accurately identify metastatic breast cancer patients with distinct long-term outcomes, potentially improving treatment decision
