Section
Five-year data from KEYNOTE-826 confirm pembrolizumab combined with chemotherapy as a durable, first-line treatment improving survival in persistent, recurrent, or metastatic cervical cancer without new safety concerns.
An international, evidence-driven consensus harmonizes diagnostic and treatment approaches for soft tissue and visceral leiomyosarcoma, emphasizing multidisciplinary care, site-specific strategies, and priorities for research.
This study reveals that immune checkpoint and VEGF inhibitors, alone or combined, do not induce detectable arterial inflammation by PET, suggesting macrophage-driven plaque activation is not the main cause of related atherothrombotic events
This study reveals how the S1P-TREM2-NRF2 signaling pathway protects tumor-associated neutrophils from ferroptosis, sustaining immunosuppression and promoting hepatocellular carcinoma progression, offering new therapeutic avenues.
A large European study shows that severe anastomotic leaks requiring surgical reintervention after esophagectomy significantly reduce long-term survival and increase postoperative mortality, underscoring the need for targeted management str
This study reveals distinct alterations in the type I interferon pathway expression and signaling linked to mutated p53 subtypes in endometrial cancer, highlighting differing immune microenvironments that impact prognosis and therapeutic co
This retrospective study compares oncologic and perioperative outcomes of minimally invasive radical hysterectomy without uterine manipulator versus open radical hysterectomy in early-stage cervical cancer, showing comparable survival but i
TP53 mutations define a high-risk AML subset with inferior survival post-allo-HCT, driven mainly by relapse. Molecular heterogeneity may guide personalized post-transplant strategies.
The Pennsylvania Rural Health Model’s implementation did not significantly change short-term cancer surgery outcomes among rural residents, suggesting that alternative approaches may be necessary to improve surgical oncology care in rural s
This multicenter study assesses recurrence patterns in medullary thyroid cancer, finding ipsilateral neck sites are the most common recurrence locations, with limited evidence supporting routine contralateral prophylactic central neck disse
Tissue-informed circulating tumor DNA assays demonstrate high detection rates and exceptional sensitivity and specificity in monitoring HPV-positive and HPV-negative head and neck squamous cell carcinoma, supporting their clinical utility i
A two-stage tracheal reconstruction approach in well-differentiated thyroid carcinoma with tracheal invasion shows high decannulation rates, functional recovery, and promising 3-year survival, supporting its use for extensive tracheal defec
This review summarizes the clinical characteristics, disease course, and survival outcomes of lung metastases after gastrectomy in gastric cancer patients, highlighting prognostic factors and the role of pulmonary metastasectomy.
A nationwide cohort study reveals that in IBD patients, colorectal cancer risk increases notably with multiple affected relatives, challenging current guidelines prioritizing early-onset family history for surveillance.
This study elucidates how distinct patterns and gradations of vascular invasion in hepatocellular carcinoma differentially impact recurrence timing and overall survival, enabling improved postoperative risk stratification.
This study elucidates transcriptomic differences between primary gastric cancers and peritoneal metastases, revealing distinct tumor microenvironments and molecular pathways, highlighting potential targets for improved diagnosis and therapy
This article explores how genetic variants affect CPEB3-mediated alternative polyadenylation in hepatocellular carcinoma, revealing potential prognostic markers and therapeutic targets to improve patient survival.
A comprehensive multinational study reveals that achalasia significantly raises the risk of esophageal squamous cell carcinoma independently, while its association with adenocarcinoma is modest and largely mediated by gastroesophageal reflu
Levothyroxine therapy lowering TSH in euthyroid PTMC patients during active surveillance raises reverse T3 levels while maintaining stable free T3, suggesting altered thyroid hormone metabolism and a compensatory adaptive response.
Presentation of three neuroendocrine tumor cases illustrating theranostics integration in diagnosis, treatment, and management, highlighting receptor-based imaging and personalized radionuclide therapy.
